YLR201C / COQ9

Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR201C / COQ9

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:18.40|P-value:7.40E-80 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.37|P-value:3.41E-6 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.19|P-value:5.39E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.25|P-value:3.45E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:17.20|P-value:5.86E-70 ID:SGTC_67|Compound:0335-0847|FD-Score:14.40|P-value:4.74E-50 ID:SGTC_86|Compound:0417-1630|FD-Score:20.10|P-value:1.21E-94 ID:SGTC_134|Compound:0269-0018|FD-Score:3.58|P-value:1.16E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.89|P-value:3.11E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:9.65|P-value:1.77E-23 ID:SGTC_150|Compound:3970-0969|FD-Score:5.68|P-value:2.53E-9 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.32|P-value:3.29E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:29.60|P-value:5.60E-204 ID:SGTC_165|Compound:k038-0023|FD-Score:6.73|P-value:2.21E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:3.98|P-value:2.10E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.04|P-value:2.20E-13 ID:SGTC_216|Compound:k038-0035|FD-Score:8.65|P-value:3.07E-19 ID:SGTC_236|Compound:1509-0011|FD-Score:25.50|P-value:1.21E-151 ID:SGTC_294|Compound:k038-0071|FD-Score:4.15|P-value:9.71E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.47|P-value:1.77E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:5.84|P-value:9.46E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:10.30|P-value:2.42E-26 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.04|P-value:9.12E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.64|P-value:9.56E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.34|P-value:4.05E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:3.21|P-value:4.71E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.11|P-value:7.17E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.32|P-value:3.32E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.29|P-value:3.50E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.53|P-value:9.71E-12 ID:SGTC_642|Compound:0335-0876|FD-Score:5.13|P-value:6.69E-8 ID:SGTC_646|Compound:4092-0839|FD-Score:4.29|P-value:5.07E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.84|P-value:3.42E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.94|P-value:1.90E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:8.45|P-value:1.81E-18 ID:SGTC_846|Compound:0335-0850|FD-Score:4.96|P-value:1.74E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.54|P-value:1.40E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.11|P-value:6.96E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.87|P-value:3.59E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.20|P-value:7.93E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.07|P-value:7.88E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:4.20|P-value:7.68E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-3.18|P-value:5.68E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.70|P-value:1.42E-33 ID:SGTC_1712|Compound:st032288|FD-Score:-3.03|P-value:9.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.06|P-value:8.61E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.16|P-value:6.04E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.65|P-value:8.95E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.49|P-value:1.75E-4 ID:SGTC_2118|Compound:5526350|FD-Score:5.10|P-value:8.04E-8 ID:SGTC_2226|Compound:7298446|FD-Score:3.91|P-value:2.82E-5 ID:SGTC_2239|Compound:6685329|FD-Score:4.76|P-value:4.81E-7 ID:SGTC_2372|Compound:9071633|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.01|P-value:9.87E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.35|P-value:2.92E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.14|P-value:1.03E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.16|P-value:6.06E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.12|P-value:6.58E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.37|P-value:2.72E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.16|P-value:6.01E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.27|P-value:4.06E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.06|P-value:8.15E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:18.40|P-value:7.40E-80 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.37|P-value:3.41E-6 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.19|P-value:5.39E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.25|P-value:3.45E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:17.20|P-value:5.86E-70 ID:SGTC_67|Compound:0335-0847|FD-Score:14.40|P-value:4.74E-50 ID:SGTC_86|Compound:0417-1630|FD-Score:20.10|P-value:1.21E-94 ID:SGTC_134|Compound:0269-0018|FD-Score:3.58|P-value:1.16E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.89|P-value:3.11E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:9.65|P-value:1.77E-23 ID:SGTC_150|Compound:3970-0969|FD-Score:5.68|P-value:2.53E-9 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.32|P-value:3.29E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:29.60|P-value:5.60E-204 ID:SGTC_165|Compound:k038-0023|FD-Score:6.73|P-value:2.21E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:3.98|P-value:2.10E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.04|P-value:2.20E-13 ID:SGTC_216|Compound:k038-0035|FD-Score:8.65|P-value:3.07E-19 ID:SGTC_236|Compound:1509-0011|FD-Score:25.50|P-value:1.21E-151 ID:SGTC_294|Compound:k038-0071|FD-Score:4.15|P-value:9.71E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.47|P-value:1.77E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:5.84|P-value:9.46E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:10.30|P-value:2.42E-26 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.04|P-value:9.12E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.64|P-value:9.56E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.34|P-value:4.05E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:3.21|P-value:4.71E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.11|P-value:7.17E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.32|P-value:3.32E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.29|P-value:3.50E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.53|P-value:9.71E-12 ID:SGTC_642|Compound:0335-0876|FD-Score:5.13|P-value:6.69E-8 ID:SGTC_646|Compound:4092-0839|FD-Score:4.29|P-value:5.07E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.84|P-value:3.42E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:4.94|P-value:1.90E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:8.45|P-value:1.81E-18 ID:SGTC_846|Compound:0335-0850|FD-Score:4.96|P-value:1.74E-7 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.54|P-value:1.40E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.11|P-value:6.96E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.87|P-value:3.59E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.20|P-value:7.93E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.07|P-value:7.88E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:4.20|P-value:7.68E-6 ID:SGTC_1626|Compound:st003712|FD-Score:-3.18|P-value:5.68E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.70|P-value:1.42E-33 ID:SGTC_1712|Compound:st032288|FD-Score:-3.03|P-value:9.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.06|P-value:8.61E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.16|P-value:6.04E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.65|P-value:8.95E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.49|P-value:1.75E-4 ID:SGTC_2118|Compound:5526350|FD-Score:5.10|P-value:8.04E-8 ID:SGTC_2226|Compound:7298446|FD-Score:3.91|P-value:2.82E-5 ID:SGTC_2239|Compound:6685329|FD-Score:4.76|P-value:4.81E-7 ID:SGTC_2372|Compound:9071633|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.01|P-value:9.87E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.35|P-value:2.92E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.14|P-value:1.03E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.16|P-value:6.06E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.12|P-value:6.58E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.37|P-value:2.72E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.16|P-value:6.01E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.27|P-value:4.06E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.06|P-value:8.15E-4

Top fitness defect scores for YLR201C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_158 k038-0087 29.60 26.4 µM 5.60E-204 ubiquinone biosynthesis & proteasome 1 2.10E-193
2 SGTC_236 1509-0011 25.50 5.3 µM 1.21E-151 30 8.43E-144
3 SGTC_86 0417-1630 20.10 471.9 µM 1.21E-94 ubiquinone biosynthesis & proteasome 3 8.91E-90
4 SGTC_36 0335-0881 18.40 14.2 µM 7.40E-80 ubiquinone biosynthesis & proteasome 7 9.18E-76
5 SGTC_64 000l-0018 17.20 272.1 µM 5.86E-70 ubiquinone biosynthesis & proteasome 17 2.21E-66
6 SGTC_67 0335-0847 14.40 266.0 µM 4.74E-50 ubiquinone biosynthesis & proteasome 11 1.63E-47
7 SGTC_1635 st007035 11.70 42.4 µM 1.42E-33 62 6.73E-32
8 SGTC_386 1509-0011 10.30 3.1 µM 2.42E-26 42 4.82E-25
9 SGTC_142 0335-0849 9.65 62.7 µM 1.77E-23 ubiquinone biosynthesis & proteasome 34 2.49E-22
10 SGTC_216 k038-0035 8.65 28.4 µM 3.07E-19 ubiquinone biosynthesis & proteasome 9 2.61E-18
11 SGTC_794 k038-0031 8.45 316.0 µM 1.81E-18 ubiquinone biosynthesis & proteasome 25 1.40E-17
12 SGTC_200 k038-0079 7.04 37.5 µM 2.20E-13 ubiquinone biosynthesis & proteasome 19 9.27E-13
13 SGTC_165 k038-0023 6.73 64.4 µM 2.21E-12 ubiquinone biosynthesis & proteasome 15 8.24E-12
14 SGTC_635 k038-0028 6.53 24.7 µM 9.71E-12 ubiquinone biosynthesis & proteasome 13 3.36E-11
15 SGTC_340 k038-0059 5.84 454.0 µM 9.46E-10 ubiquinone biosynthesis & proteasome 23 2.58E-9
16 SGTC_150 3970-0969 5.68 77.2 µM 2.53E-9 26 6.54E-9
17 SGTC_59 0330-0160 5.25 1.3 µM 3.45E-8 53 7.80E-8
18 SGTC_642 0335-0876 5.13 158.0 µM 6.69E-8 ubiquinone biosynthesis & proteasome 19 1.46E-7
19 SGTC_2118 5526350 5.10 200.0 µM 8.04E-8 3 1.74E-7
20 SGTC_846 0335-0850 4.96 148.0 µM 1.74E-7 ubiquinone biosynthesis & proteasome 18 3.62E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.848 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.828 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.803 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.788 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.758 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.744 0 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.715 0 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.659 0 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.653 0 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.623 0 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.615 0 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.607 0 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.583 2.98E-305 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.577 4.71E-297 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.575 1.70E-294 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover