YLR205C / HMX1

ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR205C / HMX1

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:3.83|P-value:7.68E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.45|P-value:5.59E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:2.81|P-value:7.33E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.03|P-value:3.13E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.95|P-value:4.77E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.53|P-value:3.75E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-5.07|P-value:6.32E-9 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.19|P-value:1.33E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:2.89|P-value:5.37E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.55|P-value:3.43E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.37|P-value:7.87E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.26|P-value:7.83E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:-4.19|P-value:1.32E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:-7.03|P-value:1.46E-15 ID:SGTC_750|Compound:4073-0104|FD-Score:-7.50|P-value:1.82E-17 ID:SGTC_827|Compound:3253-0474|FD-Score:2.90|P-value:5.26E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.35|P-value:7.69E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.15|P-value:2.05E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.54|P-value:4.23E-22 ID:SGTC_1115|Compound:galangin|FD-Score:2.78|P-value:8.36E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.43|P-value:5.38E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.62|P-value:2.43E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.60|P-value:1.36E-10 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.81|P-value:8.08E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.19|P-value:1.54E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.00|P-value:3.51E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.97|P-value:3.68E-6 ID:SGTC_2084|Compound:5306078|FD-Score:-2.99|P-value:3.96E-4 ID:SGTC_2190|Compound:6049624|FD-Score:2.76|P-value:9.02E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.93|P-value:5.11E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.85|P-value:6.37E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.25|P-value:1.21E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.27|P-value:1.10E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.60|P-value:2.41E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.10|P-value:2.51E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.75|P-value:9.54E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.76|P-value:9.11E-4 ID:SGTC_2704|Compound:st078022|FD-Score:2.91|P-value:5.07E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.31|P-value:9.42E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.24|P-value:1.27E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.21|P-value:1.61E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.85|P-value:6.27E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.05|P-value:3.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.07|P-value:2.61E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.31|P-value:9.12E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.55|P-value:3.09E-5 ID:SGTC_3012|Compound:9080433|FD-Score:2.79|P-value:7.96E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.80|P-value:7.69E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.11|P-value:2.17E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-3.00|P-value:3.84E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.31|P-value:1.02E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.83|P-value:7.68E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.45|P-value:5.59E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:2.81|P-value:7.33E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.03|P-value:3.13E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.95|P-value:4.77E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.53|P-value:3.75E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-5.07|P-value:6.32E-9 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.19|P-value:1.33E-6 ID:SGTC_656|Compound:4090-1979|FD-Score:2.89|P-value:5.37E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.55|P-value:3.43E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.37|P-value:7.87E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.26|P-value:7.83E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:-4.19|P-value:1.32E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:-7.03|P-value:1.46E-15 ID:SGTC_750|Compound:4073-0104|FD-Score:-7.50|P-value:1.82E-17 ID:SGTC_827|Compound:3253-0474|FD-Score:2.90|P-value:5.26E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.35|P-value:7.69E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.15|P-value:2.05E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.54|P-value:4.23E-22 ID:SGTC_1115|Compound:galangin|FD-Score:2.78|P-value:8.36E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.43|P-value:5.38E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.62|P-value:2.43E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.60|P-value:1.36E-10 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.81|P-value:8.08E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.19|P-value:1.54E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.00|P-value:3.51E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.97|P-value:3.68E-6 ID:SGTC_2084|Compound:5306078|FD-Score:-2.99|P-value:3.96E-4 ID:SGTC_2190|Compound:6049624|FD-Score:2.76|P-value:9.02E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.93|P-value:5.11E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.85|P-value:6.37E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.25|P-value:1.21E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.27|P-value:1.10E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.60|P-value:2.41E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.10|P-value:2.51E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.75|P-value:9.54E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.76|P-value:9.11E-4 ID:SGTC_2704|Compound:st078022|FD-Score:2.91|P-value:5.07E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.31|P-value:9.42E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.24|P-value:1.27E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.21|P-value:1.61E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.85|P-value:6.27E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.05|P-value:3.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.07|P-value:2.61E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.31|P-value:9.12E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.55|P-value:3.09E-5 ID:SGTC_3012|Compound:9080433|FD-Score:2.79|P-value:7.96E-4 ID:SGTC_3015|Compound:9080845|FD-Score:2.80|P-value:7.69E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.11|P-value:2.17E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-3.00|P-value:3.84E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.31|P-value:1.02E-4

Top fitness defect scores for YLR205C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1379 2144-0755 5.60 36.5 µM 1.36E-10 7 1.08E-8
2 SGTC_734 2023-0417 4.26 80.0 µM 7.83E-7 ergosterol biosynthesis 9 1.04E-5
3 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.97 14.9 µM 3.68E-6 11 3.57E-5
4 SGTC_32 0928-0142 3.83 34.1 µM 7.68E-6 TSC3-RPN4 8 6.42E-5
5 SGTC_2568 diosmetin 3.60 100.0 µM 2.41E-5 34 1.60E-4
6 SGTC_2978 9011784 3.55 43.0 µM 3.09E-5 46 1.94E-4
7 SGTC_1143 3454-2408 3.43 5.1 µM 5.38E-5 60S ribosome export 8 3.03E-4
8 SGTC_894 0960-0238 3.35 55.9 µM 7.69E-5 26 4.03E-4
9 SGTC_2898 9056270 3.31 58.4 µM 9.12E-5 12 4.61E-4
10 SGTC_2757 clomiphene 3.31 4.2 µM 9.42E-5 fatty acid desaturase (OLE1) 72 4.74E-4
11 SGTC_2516 gossypol 3.27 71.5 µM 1.10E-4 37 5.37E-4
12 SGTC_2487 5918373 3.25 44.0 µM 1.21E-4 42 5.78E-4
13 SGTC_2821 7996764 3.24 71.4 µM 1.27E-4 71 6.01E-4
14 SGTC_1753 st043925 3.19 64.0 µM 1.54E-4 27 7.01E-4
15 SGTC_3042 9091578 3.11 49.5 µM 2.17E-4 ERG2 22 9.23E-4
16 SGTC_2896 9052656 3.07 71.4 µM 2.61E-4 endomembrane recycling 197 0.00107
17 SGTC_369 0957-0393 3.03 4.5 µM 3.13E-4 cell wall signaling 68 0.00124
18 SGTC_1756 st041558 3.00 35.5 µM 3.51E-4 33 0.00135
19 SGTC_2704 st078022 2.91 71.1 µM 5.07E-4 46 0.00182
20 SGTC_827 3253-0474 2.90 693.0 µM 5.26E-4 70 0.00187

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.371 5.42E-110 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.317 6.77E-79 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.302 1.73E-71 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.299 3.83E-70 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.283 1.15E-62 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.283 1.24E-62 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.278 2.21E-60 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.275 2.02E-59 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.271 1.34E-57 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.261 1.72E-53 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.261 2.59E-53 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.256 3.01E-51 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.250 6.82E-49 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.249 1.61E-48 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.248 2.78E-48 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane