YLR206W / ENT2

Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR206W / ENT2

Click on Significant Values for Screen Details ID:SGTC_196|Compound:k015-0023|FD-Score:-2.90|P-value:5.61E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.44|P-value:3.86E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:2.97|P-value:3.11E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:2.88|P-value:4.53E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.99|P-value:3.34E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.27|P-value:4.64E-7 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.83|P-value:5.57E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.99|P-value:3.81E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.24|P-value:1.35E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.14|P-value:2.07E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.41|P-value:6.26E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.16|P-value:1.36E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.69|P-value:9.48E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.76|P-value:7.20E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.77|P-value:9.31E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.80|P-value:6.41E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.82|P-value:8.21E-6 ID:SGTC_1660|Compound:st012960|FD-Score:3.71|P-value:1.01E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.09|P-value:1.84E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.59|P-value:1.80E-5 ID:SGTC_1801|Compound:st050089|FD-Score:2.97|P-value:3.13E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.04|P-value:2.29E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.84|P-value:5.27E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.34|P-value:8.31E-5 ID:SGTC_1821|Compound:st053465|FD-Score:-4.49|P-value:1.94E-7 ID:SGTC_2002|Compound:4023503|FD-Score:2.90|P-value:4.17E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.03|P-value:3.27E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.27|P-value:8.51E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-3.08|P-value:2.66E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.27|P-value:8.27E-5 ID:SGTC_2425|Compound:5628681|FD-Score:4.57|P-value:7.85E-8 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.02|P-value:2.46E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.96|P-value:3.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.95|P-value:2.96E-30 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.74|P-value:7.81E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.63|P-value:2.11E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.30|P-value:1.01E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.79|P-value:9.48E-6 ID:SGTC_2978|Compound:9011784|FD-Score:4.34|P-value:3.17E-7 ID:SGTC_2989|Compound:9073649|FD-Score:4.17|P-value:8.47E-7 ID:SGTC_3001|Compound:9076041|FD-Score:-3.57|P-value:2.83E-5 ID:SGTC_3025|Compound:9087895|FD-Score:2.96|P-value:3.16E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.01|P-value:2.63E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-2.90|P-value:5.61E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.44|P-value:3.86E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:2.97|P-value:3.11E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:2.88|P-value:4.53E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.99|P-value:3.34E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.27|P-value:4.64E-7 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.83|P-value:5.57E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.99|P-value:3.81E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.24|P-value:1.35E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.14|P-value:2.07E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.41|P-value:6.26E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.16|P-value:1.36E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.69|P-value:9.48E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.76|P-value:7.20E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-2.77|P-value:9.31E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.80|P-value:6.41E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.82|P-value:8.21E-6 ID:SGTC_1660|Compound:st012960|FD-Score:3.71|P-value:1.01E-5 ID:SGTC_1703|Compound:st026983|FD-Score:3.09|P-value:1.84E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.59|P-value:1.80E-5 ID:SGTC_1801|Compound:st050089|FD-Score:2.97|P-value:3.13E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.04|P-value:2.29E-4 ID:SGTC_1811|Compound:st050069|FD-Score:2.84|P-value:5.27E-4 ID:SGTC_1816|Compound:st051957|FD-Score:-3.34|P-value:8.31E-5 ID:SGTC_1821|Compound:st053465|FD-Score:-4.49|P-value:1.94E-7 ID:SGTC_2002|Compound:4023503|FD-Score:2.90|P-value:4.17E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.03|P-value:3.27E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.27|P-value:8.51E-5 ID:SGTC_2329|Compound:6138490|FD-Score:-3.08|P-value:2.66E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.27|P-value:8.27E-5 ID:SGTC_2425|Compound:5628681|FD-Score:4.57|P-value:7.85E-8 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.02|P-value:2.46E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.96|P-value:3.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.95|P-value:2.96E-30 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.74|P-value:7.81E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.63|P-value:2.11E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.30|P-value:1.01E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.68|P-value:9.74E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.79|P-value:9.48E-6 ID:SGTC_2978|Compound:9011784|FD-Score:4.34|P-value:3.17E-7 ID:SGTC_2989|Compound:9073649|FD-Score:4.17|P-value:8.47E-7 ID:SGTC_3001|Compound:9076041|FD-Score:-3.57|P-value:2.83E-5 ID:SGTC_3025|Compound:9087895|FD-Score:2.96|P-value:3.16E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.01|P-value:2.63E-4

Top fitness defect scores for YLR206W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 9.95 100.0 µM 2.96E-30 redox potentiating 63 1.28E-23
2 SGTC_2425 5628681 4.57 7.8 µM 7.85E-8 9 2.45E-6
3 SGTC_2978 9011784 4.34 43.0 µM 3.17E-7 20 7.21E-6
4 SGTC_1269 0831-0796 4.27 3.0 µM 4.64E-7 60S ribosome export 12 9.67E-6
5 SGTC_2989 9073649 4.17 71.4 µM 8.47E-7 28 1.54E-5
6 SGTC_1514 1189-1591 3.80 158.0 µM 6.41E-6 40 7.38E-5
7 SGTC_1660 st012960 3.71 28.1 µM 1.01E-5 iron homeostasis 47 1.05E-4
8 SGTC_1799 st045822 3.59 46.1 µM 1.80E-5 21 1.64E-4
9 SGTC_338 4055-0136 3.44 114.0 µM 3.86E-5 20 2.96E-4
10 SGTC_2414 st077232 3.27 92.9 µM 8.27E-5 44 5.35E-4
11 SGTC_2316 5844804 3.27 197.4 µM 8.51E-5 70 5.47E-4
12 SGTC_1412 3909-8563 3.16 178.0 µM 1.36E-4 32 7.85E-4
13 SGTC_1703 st026983 3.09 48.3 µM 1.84E-4 45 9.96E-4
14 SGTC_1809 st050081 3.04 57.6 µM 2.29E-4 56 0.00118
15 SGTC_2514 salinomycin 3.02 42.7 µM 2.46E-4 103 0.00125
16 SGTC_3042 9091578 3.01 49.5 µM 2.63E-4 ERG2 26 0.00131
17 SGTC_549 1661-1316 2.97 519.0 µM 3.11E-4 59 0.00150
18 SGTC_1801 st050089 2.97 28.4 µM 3.13E-4 NEO1-PIK1 201 0.00150
19 SGTC_3025 9087895 2.96 49.5 µM 3.16E-4 PDR1 76 0.00152
20 SGTC_2519 cryptotanshinone 2.96 88.0 µM 3.17E-4 heme biosynthesis & mitochondrial translocase 45 0.00152

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.326 1.19E-83 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.320 9.89E-81 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.296 9.74E-69 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.294 8.76E-68 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.287 9.71E-65 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.276 8.10E-60 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.274 1.18E-58 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.259 2.03E-52 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.258 3.83E-52 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.250 4.96E-49 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.241 2.15E-45 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.232 2.43E-42 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.220 3.27E-38 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.215 2.69E-36 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.207 6.76E-34 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription