YLR216C / CPR6

Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR216C / CPR6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.84|P-value:8.45E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.29|P-value:1.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.64|P-value:2.05E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:2.74|P-value:9.65E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.37|P-value:9.21E-5 ID:SGTC_493|Compound:zm226600|FD-Score:3.07|P-value:2.58E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-4.24|P-value:1.23E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.81|P-value:7.52E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-4.26|P-value:1.09E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.29|P-value:1.02E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.17|P-value:1.74E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.11|P-value:2.85E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.77|P-value:1.06E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:2.79|P-value:8.13E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.46|P-value:3.52E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:1.99E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.20|P-value:1.12E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.24|P-value:1.27E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.29|P-value:6.92E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:-2.90|P-value:6.66E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-2.87|P-value:7.36E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.56|P-value:3.87E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.19|P-value:1.61E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.30|P-value:1.26E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.13|P-value:2.02E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.90|P-value:5.50E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.46|P-value:3.51E-7 ID:SGTC_1927|Compound:st060202|FD-Score:2.93|P-value:4.56E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.70|P-value:1.50E-5 ID:SGTC_2094|Compound:5332512|FD-Score:2.90|P-value:5.23E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-2.97|P-value:5.04E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:2.86|P-value:6.19E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.90|P-value:2.55E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.21|P-value:1.48E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.45|P-value:5.01E-5 ID:SGTC_2916|Compound:7875993|FD-Score:4.04|P-value:2.67E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.01|P-value:4.32E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.36|P-value:9.68E-5 ID:SGTC_3096|Compound:9117468|FD-Score:2.95|P-value:4.33E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-2.94|P-value:5.57E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.84|P-value:8.45E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.29|P-value:1.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.64|P-value:2.05E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:2.74|P-value:9.65E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.37|P-value:9.21E-5 ID:SGTC_493|Compound:zm226600|FD-Score:3.07|P-value:2.58E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-4.24|P-value:1.23E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.81|P-value:7.52E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-4.26|P-value:1.09E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:3.29|P-value:1.02E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.17|P-value:1.74E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.11|P-value:2.85E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.77|P-value:1.06E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:2.79|P-value:8.13E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.46|P-value:3.52E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:1.99E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.20|P-value:1.12E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.24|P-value:1.27E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.29|P-value:6.92E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:-2.90|P-value:6.66E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-2.87|P-value:7.36E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.56|P-value:3.87E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.19|P-value:1.61E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.30|P-value:1.26E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.13|P-value:2.02E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.90|P-value:5.50E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.46|P-value:3.51E-7 ID:SGTC_1927|Compound:st060202|FD-Score:2.93|P-value:4.56E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.70|P-value:1.50E-5 ID:SGTC_2094|Compound:5332512|FD-Score:2.90|P-value:5.23E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-2.97|P-value:5.04E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:2.86|P-value:6.19E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.90|P-value:2.55E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.21|P-value:1.48E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.45|P-value:5.01E-5 ID:SGTC_2916|Compound:7875993|FD-Score:4.04|P-value:2.67E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.01|P-value:4.32E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.36|P-value:9.68E-5 ID:SGTC_3096|Compound:9117468|FD-Score:2.95|P-value:4.33E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-2.94|P-value:5.57E-4

Top fitness defect scores for YLR216C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1132 3456-3614 4.29 2.5 µM 6.92E-7 tubulin folding & SWR complex 29 9.11E-6
2 SGTC_1118 chelidonine 4.20 707.5 nM 1.12E-6 15 1.34E-5
3 SGTC_2916 7875993 4.04 68.8 µM 2.67E-6 25 2.69E-5
4 SGTC_1698 5-fluorocytosine 3.90 1.1 µM 5.50E-6 exosome 10 4.80E-5
5 SGTC_918 glabranin 3.77 770.7 nM 1.06E-5 39 8.15E-5
6 SGTC_2052 5265182 3.70 7.1 µM 1.50E-5 38 1.07E-4
7 SGTC_221 trifluoperazine 3.64 10.3 µM 2.05E-5 NEO1-PIK1 228 1.38E-4
8 SGTC_2780 5215298 3.45 71.4 µM 5.01E-5 57 2.82E-4
9 SGTC_859 0439-0102 3.29 54.6 µM 1.02E-4 redox potentiating 32 5.00E-4
10 SGTC_1129 3453-1384 3.24 223.0 µM 1.27E-4 73 5.96E-4
11 SGTC_2688 kanamycin b 3.21 96.7 µM 1.48E-4 calcium & mitochondrial duress 493 6.74E-4
12 SGTC_1480 1070-0044 3.19 41.2 µM 1.61E-4 41 7.20E-4
13 SGTC_863 0466-0191 3.17 129.0 µM 1.74E-4 cell wall 112 7.69E-4
14 SGTC_1621 st003705 3.13 32.4 µM 2.02E-4 calcium & mitochondrial duress 55 8.67E-4
15 SGTC_493 zm226600 3.07 134.0 µM 2.58E-4 mitochondrial processes 48 0.00105
16 SGTC_3096 9117468 2.95 49.5 µM 4.33E-4 30 0.00160
17 SGTC_1927 st060202 2.93 13.8 µM 4.56E-4 64 0.00167
18 SGTC_2094 5332512 2.90 191.7 µM 5.23E-4 76 0.00186
19 SGTC_2576 guaiol 2.86 23.1 µM 6.19E-4 98 0.00213
20 SGTC_511 blebbistatin 2.81 171.0 µM 7.52E-4 DNA intercalators 74 0.00250

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.209 2.18E-34 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.154 2.63E-19 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.151 1.62E-18 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.144 4.11E-17 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.143 9.83E-17 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.142 1.20E-16 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.134 5.43E-15 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.124 5.85E-13 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.123 8.68E-13 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.120 3.40E-12 YDR242W AMD2 hom Putative amidase
0.119 4.67E-12 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.119 5.08E-12 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.118 7.13E-12 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.118 8.01E-12 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.116 1.46E-11 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels