YLR222C / UTP13

Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR222C / UTP13

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:-3.35|P-value:8.82E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.18|P-value:3.18E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.25|P-value:2.34E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:3.81|P-value:1.29E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.44|P-value:4.85E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.66|P-value:2.22E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.67|P-value:3.02E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.02|P-value:5.86E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.43|P-value:1.13E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.31|P-value:7.49E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:8.32|P-value:1.18E-15 ID:SGTC_625|Compound:k213-0058|FD-Score:3.47|P-value:4.39E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.88|P-value:1.03E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.44|P-value:4.89E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.49|P-value:4.08E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.89|P-value:9.92E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.92|P-value:1.29E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.11|P-value:6.10E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.48|P-value:9.21E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-6.00|P-value:9.09E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-10.50|P-value:2.40E-23 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.89|P-value:9.81E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.81|P-value:1.87E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.41|P-value:7.41E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.51|P-value:5.21E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.49|P-value:5.57E-4 ID:SGTC_1663|Compound:st014140|FD-Score:-3.49|P-value:5.58E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.45|P-value:4.63E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.34|P-value:9.27E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-3.64|P-value:3.41E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.77|P-value:2.12E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.80|P-value:1.95E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.50|P-value:1.28E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:3.93E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.78|P-value:2.05E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.91|P-value:1.39E-6 ID:SGTC_2266|Compound:7929956|FD-Score:3.62|P-value:2.60E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.30|P-value:1.91E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.58|P-value:2.95E-4 ID:SGTC_2702|Compound:st077768|FD-Score:5.92|P-value:8.01E-9 ID:SGTC_2709|Compound:st078560|FD-Score:3.41|P-value:5.40E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.61|P-value:8.03E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-4.17|P-value:4.78E-5 ID:SGTC_2934|Compound:9036370|FD-Score:4.49|P-value:8.71E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.60|P-value:3.88E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.35|P-value:8.82E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.18|P-value:3.18E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.25|P-value:2.34E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:3.81|P-value:1.29E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.44|P-value:4.85E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.66|P-value:2.22E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.67|P-value:3.02E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.02|P-value:5.86E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.43|P-value:1.13E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.31|P-value:7.49E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:8.32|P-value:1.18E-15 ID:SGTC_625|Compound:k213-0058|FD-Score:3.47|P-value:4.39E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.88|P-value:1.03E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.44|P-value:4.89E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.49|P-value:4.08E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.89|P-value:9.92E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.92|P-value:1.29E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.11|P-value:6.10E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.48|P-value:9.21E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:-6.00|P-value:9.09E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:-10.50|P-value:2.40E-23 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.89|P-value:9.81E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.81|P-value:1.87E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.41|P-value:7.41E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.51|P-value:5.21E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.49|P-value:5.57E-4 ID:SGTC_1663|Compound:st014140|FD-Score:-3.49|P-value:5.58E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.45|P-value:4.63E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-3.34|P-value:9.27E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-3.64|P-value:3.41E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.77|P-value:2.12E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-3.80|P-value:1.95E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.50|P-value:1.28E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:3.93E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.78|P-value:2.05E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.84|P-value:1.19E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.91|P-value:1.39E-6 ID:SGTC_2266|Compound:7929956|FD-Score:3.62|P-value:2.60E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.30|P-value:1.91E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.58|P-value:2.95E-4 ID:SGTC_2702|Compound:st077768|FD-Score:5.92|P-value:8.01E-9 ID:SGTC_2709|Compound:st078560|FD-Score:3.41|P-value:5.40E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.61|P-value:8.03E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-4.17|P-value:4.78E-5 ID:SGTC_2934|Compound:9036370|FD-Score:4.49|P-value:8.71E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.60|P-value:3.88E-4

Top fitness defect scores for YLR222C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_617 3770-0098 8.32 35.0 µM 1.18E-15 exosome 8 4.25E-17 0.44
2 SGTC_2702 st077768 5.92 96.8 µM 8.01E-9 1 1.57E-9 1.26
3 SGTC_800 3448-7362 4.92 155.0 µM 1.29E-6 translation 34 4.31E-7 0.10
4 SGTC_2203 7227154 4.91 166.4 µM 1.39E-6 1 4.66E-7 0.89
5 SGTC_2934 9036370 4.49 36.9 µM 8.71E-6 3 3.52E-6 0.43
6 SGTC_1178 0988-0033 4.48 191.0 µM 9.21E-6 4 3.74E-6 0.30
7 SGTC_572 0960-0087 4.43 17.7 µM 1.13E-5 7 4.67E-6 0.07
8 SGTC_2307 7538926 4.30 6.3 µM 1.91E-5 19 8.35E-6 0.19
9 SGTC_118 0083-0097 4.25 135.3 µM 2.34E-5 translation 14 1.05E-5 0.00
10 SGTC_114 0364-0001 4.18 490.3 µM 3.18E-5 2 1.46E-5 0.07
11 SGTC_549 1661-1316 4.02 519.0 µM 5.86E-5 6 2.87E-5 0.06
12 SGTC_1323 1348-1351 3.89 11.2 µM 9.81E-5 3 5.05E-5 0.09
13 SGTC_724 3910-0327 3.89 137.0 µM 9.92E-5 ERG2 5 5.12E-5 0.14
14 SGTC_626 0214-0009 3.88 33.0 µM 1.03E-4 copper-dependent oxidative stress 3 5.30E-5 0.10
15 SGTC_2058 5236698 3.84 133.0 µM 1.19E-4 4 6.22E-5 0.01
16 SGTC_189 3970-0742 3.81 2.1 µM 1.29E-4 3 6.83E-5 0.57
17 SGTC_2940 9060638 3.67 45.9 µM 2.21E-4 amide catabolism 8 1.23E-4 0.23
18 SGTC_386 1509-0011 3.66 3.1 µM 2.22E-4 9 1.24E-4 0.21
19 SGTC_2266 7929956 3.62 200.0 µM 2.60E-4 7 1.48E-4 0.23
20 SGTC_2339 9000433 3.58 200.0 µM 2.95E-4 7 1.69E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 7.39E-38 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.214 4.15E-36 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.180 7.10E-26 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.179 1.04E-25 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.178 3.13E-25 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.161 7.46E-21 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.154 3.47E-19 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.150 2.25E-18 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.140 3.34E-16 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.138 1.26E-15 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.137 1.43E-15 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.131 2.20E-14 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.117 1.14E-11 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.114 3.69E-11 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.113 4.83E-11 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)