YLR223C / IFH1

Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR223C / IFH1

Click on Significant Values for Screen Details ID:SGTC_372|Compound:0155-0182|FD-Score:3.65|P-value:1.25E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:2.81|P-value:5.74E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.44|P-value:3.07E-10 ID:SGTC_791|Compound:1348-1292|FD-Score:2.77|P-value:6.53E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.05|P-value:2.75E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.04|P-value:2.13E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.10|P-value:2.27E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.24|P-value:8.96E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:1.41E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.64|P-value:1.28E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.19|P-value:1.55E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.24|P-value:1.22E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:2.76|P-value:6.77E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.04|P-value:2.20E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.09|P-value:2.33E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.34|P-value:5.59E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-2.92|P-value:4.83E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.38|P-value:6.55E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.88|P-value:4.20E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.81|P-value:5.70E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.73|P-value:7.62E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.72|P-value:8.11E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-2.84|P-value:6.73E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-2.95|P-value:4.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.82|P-value:1.40E-8 ID:SGTC_2296|Compound:7971656|FD-Score:2.97|P-value:2.88E-4 ID:SGTC_2361|Compound:9034121|FD-Score:2.82|P-value:5.31E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.69|P-value:8.93E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-4.01|P-value:2.65E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.95|P-value:3.17E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.27|P-value:7.77E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.08|P-value:1.78E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.14|P-value:1.36E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.63|P-value:1.33E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.36|P-value:5.55E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:3.65|P-value:1.25E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:2.81|P-value:5.74E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.44|P-value:3.07E-10 ID:SGTC_791|Compound:1348-1292|FD-Score:2.77|P-value:6.53E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.05|P-value:2.75E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.04|P-value:2.13E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.10|P-value:2.27E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.24|P-value:8.96E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.70|P-value:1.41E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.64|P-value:1.28E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.19|P-value:1.55E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.24|P-value:1.22E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:2.76|P-value:6.77E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.04|P-value:2.20E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.09|P-value:2.33E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.34|P-value:5.59E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-2.92|P-value:4.83E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.38|P-value:6.55E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.88|P-value:4.20E-4 ID:SGTC_2045|Compound:5106652|FD-Score:2.81|P-value:5.70E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.73|P-value:7.62E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.72|P-value:8.11E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-2.84|P-value:6.73E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-2.95|P-value:4.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.82|P-value:1.40E-8 ID:SGTC_2296|Compound:7971656|FD-Score:2.97|P-value:2.88E-4 ID:SGTC_2361|Compound:9034121|FD-Score:2.82|P-value:5.31E-4 ID:SGTC_2362|Compound:9071156|FD-Score:2.69|P-value:8.93E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-4.01|P-value:2.65E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.95|P-value:3.17E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.27|P-value:7.77E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.08|P-value:1.78E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.14|P-value:1.36E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.63|P-value:1.33E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-5.36|P-value:5.55E-10

Top fitness defect scores for YLR223C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2200 6600604 4.82 21.9 µM 1.40E-8 tubulin folding & SWR complex 2 7.30E-7 0.11
2 SGTC_372 0155-0182 3.65 15.9 µM 1.25E-5 mitochondrial response to ROS 8 1.32E-4 0.06
3 SGTC_1136 pergolide 3.64 1.1 µM 1.28E-5 25 1.35E-4 0.04
4 SGTC_2899 9053889 3.63 58.4 µM 1.33E-5 2 1.39E-4 0.10
5 SGTC_1736 st036774 3.34 51.0 µM 5.59E-5 7 4.19E-4 0.18
6 SGTC_2679 rapamycin 3.27 1.0 nM 7.77E-5 65 5.39E-4 0.00
7 SGTC_1020 4335-0961 3.24 93.3 µM 8.96E-5 16 6.02E-4 0.04
8 SGTC_2898 9056270 3.14 58.4 µM 1.36E-4 1 8.32E-4 0.21
9 SGTC_2891 9063876 3.08 19.5 µM 1.78E-4 4 0.00102 0.07
10 SGTC_807 1315-0151 3.04 48.0 µM 2.13E-4 25 0.00117 0.03
11 SGTC_1525 8-methoxypsoralen 3.04 92.5 µM 2.20E-4 DNA damage response 31 0.00120 0.00
12 SGTC_2296 7971656 2.97 126.5 µM 2.88E-4 15 0.00148 0.14
13 SGTC_2568 diosmetin 2.95 100.0 µM 3.17E-4 23 0.00159 0.05
14 SGTC_2035 5154463 2.88 94.6 µM 4.20E-4 27 0.00197 0.02
15 SGTC_2361 9034121 2.82 116.0 µM 5.31E-4 RSC complex & mRNA processing 36 0.00237 0.01
16 SGTC_2045 5106652 2.81 78.0 µM 5.70E-4 9 0.00250 0.07
17 SGTC_639 0833-0042 2.81 114.0 µM 5.74E-4 17 0.00251 0.00
18 SGTC_791 1348-1292 2.77 225.0 µM 6.53E-4 12 0.00278 0.15
19 SGTC_1403 3909-7815 2.76 62.9 µM 6.77E-4 13 0.00286 0.04
20 SGTC_2048 5246248 2.73 200.0 µM 7.62E-4 11 0.00313 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.274 6.14E-59 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.242 7.48E-46 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.230 1.55E-41 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.227 2.26E-40 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.226 3.47E-40 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.224 2.10E-39 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.222 8.49E-39 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.215 1.84E-36 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.214 3.64E-36 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.210 6.56E-35 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.209 1.54E-34 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.209 1.84E-34 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.204 5.15E-33 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.204 8.87E-33 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.202 2.88E-32 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core