YLR224W_p

F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR224W / YLR224W

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.31|P-value:1.22E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.31|P-value:1.26E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-2.89|P-value:6.83E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.02|P-value:4.11E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.23|P-value:1.80E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-2.94|P-value:5.68E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.88|P-value:3.40E-8 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.83|P-value:8.87E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.41|P-value:8.10E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.39|P-value:8.64E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.98|P-value:5.04E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.60|P-value:3.51E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.11|P-value:2.97E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.94|P-value:5.71E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.46|P-value:6.47E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.11|P-value:2.99E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.40|P-value:8.62E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.19|P-value:2.13E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.99|P-value:4.65E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.03|P-value:3.88E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.26|P-value:1.51E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.99|P-value:5.08E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.22|P-value:1.83E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.62|P-value:1.65E-7 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.98|P-value:1.77E-8 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-6.11|P-value:6.69E-12 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.59|P-value:3.68E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.82|P-value:1.21E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:2.93|P-value:6.12E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.09|P-value:3.16E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.71|P-value:2.04E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-3.09|P-value:3.14E-4 ID:SGTC_3001|Compound:9076041|FD-Score:2.81|P-value:9.58E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.32|P-value:1.23E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.17|P-value:2.06E-6 ID:SGTC_3179|Compound:9107801|FD-Score:3.71|P-value:2.11E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.01|P-value:4.40E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.30|P-value:1.36E-4 ID:SGTC_3307|Compound:9126885|FD-Score:6.66|P-value:9.36E-14 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.31|P-value:1.22E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.31|P-value:1.26E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-2.89|P-value:6.83E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-3.02|P-value:4.11E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.23|P-value:1.80E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-2.94|P-value:5.68E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.88|P-value:3.40E-8 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.83|P-value:8.87E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.41|P-value:8.10E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.39|P-value:8.64E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.98|P-value:5.04E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.60|P-value:3.51E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.11|P-value:2.97E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.94|P-value:5.71E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.46|P-value:6.47E-5 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.11|P-value:2.99E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.40|P-value:8.62E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.19|P-value:2.13E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-2.99|P-value:4.65E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.03|P-value:3.88E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.26|P-value:1.51E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.99|P-value:5.08E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.22|P-value:1.83E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.62|P-value:1.65E-7 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.98|P-value:1.77E-8 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-6.11|P-value:6.69E-12 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.59|P-value:3.68E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.82|P-value:1.21E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:2.93|P-value:6.12E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.09|P-value:3.16E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.71|P-value:2.04E-5 ID:SGTC_2998|Compound:9066762|FD-Score:-3.09|P-value:3.14E-4 ID:SGTC_3001|Compound:9076041|FD-Score:2.81|P-value:9.58E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.32|P-value:1.23E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.17|P-value:2.06E-6 ID:SGTC_3179|Compound:9107801|FD-Score:3.71|P-value:2.11E-5 ID:SGTC_3269|Compound:9137823|FD-Score:3.01|P-value:4.40E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.30|P-value:1.36E-4 ID:SGTC_3307|Compound:9126885|FD-Score:6.66|P-value:9.36E-14

Top fitness defect scores for YLR224W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3307 9126885 6.66 69.3 µM 9.36E-14 4 1.40E-11
2 SGTC_545 4218-0007 4.88 221.0 µM 3.40E-8 12 5.22E-7
3 SGTC_2539 epi(13)torulosol 4.62 80.0 µM 1.65E-7 13 1.92E-6
4 SGTC_3061 glucosamine 4.17 200.0 µM 2.06E-6 6 1.54E-5
5 SGTC_2533 agelasine 3.99 13.7 µM 5.08E-6 ERG2 48 3.24E-5
6 SGTC_2679 rapamycin 3.82 1.0 nM 1.21E-5 154 6.64E-5
7 SGTC_2983 9022671 3.71 13.0 µM 2.04E-5 60S ribosome export 16 1.02E-4
8 SGTC_3179 9107801 3.71 49.5 µM 2.11E-5 13 1.05E-4
9 SGTC_1150 3909-7983 3.60 10.9 µM 3.51E-5 37 1.60E-4
10 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.59 100.0 µM 3.68E-5 60S ribosome export 34 1.67E-4
11 SGTC_1454 4239-0054 3.46 42.6 µM 6.47E-5 50 2.65E-4
12 SGTC_911 3456-4043 3.41 236.0 µM 8.10E-5 mitochondrial processes 47 3.20E-4
13 SGTC_1496 4469-0713 3.40 57.4 µM 8.62E-5 34 3.36E-4
14 SGTC_3013 9080133 3.32 71.4 µM 1.23E-4 49 4.52E-4
15 SGTC_3299 9121982 3.30 43.1 µM 1.36E-4 55 4.91E-4
16 SGTC_261 5-fluorouridine 3.23 15.4 µM 1.80E-4 exosome 42 6.18E-4
17 SGTC_1844 rapamycin 3.19 4.0 nM 2.13E-4 219 7.13E-4
18 SGTC_1704 st028805 3.11 70.8 µM 2.95E-4 34 9.33E-4
19 SGTC_1198 1612-1005 3.11 86.7 µM 2.97E-4 42 9.38E-4
20 SGTC_1492 4158-0558 3.11 28.5 µM 2.99E-4 60S ribosome export 40 9.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.42E-25 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.155 1.74E-19 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.154 3.01E-19 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.148 8.25E-18 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.142 1.19E-16 YIL008W URM1 hom Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response
0.131 2.45E-14 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.127 1.42E-13 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.125 3.84E-13 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.125 4.29E-13 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.122 1.45E-12 YFR019W FAB1 hom 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
0.121 2.37E-12 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.120 3.05E-12 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.119 5.25E-12 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.118 8.27E-12 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.117 1.09E-11 YIL017C VID28 hom GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm