YLR227C / ADY4

Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR227C / ADY4

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:4.63|P-value:3.43E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:3.20|P-value:2.83E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.96|P-value:9.07E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.38|P-value:1.79E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.03|P-value:5.51E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.61|P-value:5.33E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.51|P-value:8.03E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:4.25|P-value:2.50E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.08|P-value:4.65E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.69|P-value:2.52E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:2.95|P-value:7.49E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.96|P-value:1.08E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.86|P-value:1.69E-10 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.53|P-value:9.81E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.23|P-value:2.76E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.11|P-value:4.14E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-2.99|P-value:8.01E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.53|P-value:7.37E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.16|P-value:4.32E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.19|P-value:3.05E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-2.96|P-value:9.02E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.20|P-value:2.85E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.61|P-value:5.31E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.14|P-value:3.71E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.45|P-value:1.26E-6 ID:SGTC_1829|Compound:berberine|FD-Score:3.69|P-value:3.70E-5 ID:SGTC_1834|Compound:st055981|FD-Score:2.97|P-value:6.85E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.02|P-value:7.37E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.07|P-value:6.06E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.24|P-value:2.42E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.14|P-value:3.65E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.78|P-value:1.49E-7 ID:SGTC_2099|Compound:5377090|FD-Score:3.56|P-value:6.50E-5 ID:SGTC_2190|Compound:6049624|FD-Score:-4.05|P-value:9.38E-6 ID:SGTC_2191|Compound:5911152|FD-Score:-3.01|P-value:7.63E-4 ID:SGTC_2195|Compound:6536160|FD-Score:2.99|P-value:6.47E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.59|P-value:7.63E-5 ID:SGTC_2228|Compound:7354201|FD-Score:4.07|P-value:6.19E-6 ID:SGTC_2238|Compound:6671620|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.40|P-value:1.30E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.94|P-value:1.14E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.73|P-value:3.13E-5 ID:SGTC_2337|Compound:9009472|FD-Score:4.78|P-value:1.52E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.28|P-value:2.70E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-4.34|P-value:2.16E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.59|P-value:5.91E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.07|P-value:6.15E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-3.03|P-value:7.00E-4 ID:SGTC_2797|Compound:7859098|FD-Score:5.26|P-value:8.76E-9 ID:SGTC_2803|Compound:7707263|FD-Score:-3.05|P-value:6.45E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.09|P-value:5.53E-4 ID:SGTC_2914|Compound:7968218|FD-Score:2.87|P-value:9.84E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.63|P-value:3.43E-7 ID:SGTC_364|Compound:0083-0097|FD-Score:3.20|P-value:2.83E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.96|P-value:9.07E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.38|P-value:1.79E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.03|P-value:5.51E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.61|P-value:5.33E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.51|P-value:8.03E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:4.25|P-value:2.50E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.08|P-value:4.65E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.69|P-value:2.52E-7 ID:SGTC_746|Compound:1095-0025|FD-Score:2.95|P-value:7.49E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.96|P-value:1.08E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.86|P-value:1.69E-10 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.53|P-value:9.81E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.23|P-value:2.76E-6 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.11|P-value:4.14E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-2.99|P-value:8.01E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.53|P-value:7.37E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.16|P-value:4.32E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.19|P-value:3.05E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-2.96|P-value:9.02E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.20|P-value:2.85E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.61|P-value:5.31E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.14|P-value:3.71E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.45|P-value:1.26E-6 ID:SGTC_1829|Compound:berberine|FD-Score:3.69|P-value:3.70E-5 ID:SGTC_1834|Compound:st055981|FD-Score:2.97|P-value:6.85E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.02|P-value:7.37E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.07|P-value:6.06E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.24|P-value:2.42E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.14|P-value:3.65E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.78|P-value:1.49E-7 ID:SGTC_2099|Compound:5377090|FD-Score:3.56|P-value:6.50E-5 ID:SGTC_2190|Compound:6049624|FD-Score:-4.05|P-value:9.38E-6 ID:SGTC_2191|Compound:5911152|FD-Score:-3.01|P-value:7.63E-4 ID:SGTC_2195|Compound:6536160|FD-Score:2.99|P-value:6.47E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.59|P-value:7.63E-5 ID:SGTC_2228|Compound:7354201|FD-Score:4.07|P-value:6.19E-6 ID:SGTC_2238|Compound:6671620|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.40|P-value:1.30E-4 ID:SGTC_2256|Compound:7954252|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.94|P-value:1.14E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.73|P-value:3.13E-5 ID:SGTC_2337|Compound:9009472|FD-Score:4.78|P-value:1.52E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.28|P-value:2.70E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-4.34|P-value:2.16E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.59|P-value:5.91E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:4.07|P-value:6.15E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-3.03|P-value:7.00E-4 ID:SGTC_2797|Compound:7859098|FD-Score:5.26|P-value:8.76E-9 ID:SGTC_2803|Compound:7707263|FD-Score:-3.05|P-value:6.45E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.09|P-value:5.53E-4 ID:SGTC_2914|Compound:7968218|FD-Score:2.87|P-value:9.84E-4

Top fitness defect scores for YLR227C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1009 4106-0057 5.86 9.9 µM 1.69E-10 1 2.26E-9
2 SGTC_2797 7859098 5.26 81.8 µM 8.76E-9 8 7.28E-8
3 SGTC_2016 5121758 4.78 140.0 µM 1.49E-7 redox potentiating 21 8.79E-7
4 SGTC_2337 9009472 4.78 200.0 µM 1.52E-7 15 8.96E-7
5 SGTC_737 1950-0117 4.69 57.9 µM 2.52E-7 12 1.40E-6
6 SGTC_68 0986-0284 4.63 82.8 µM 3.43E-7 47 1.83E-6
7 SGTC_606 k015-0008 4.25 38.6 µM 2.50E-6 7 1.05E-5
8 SGTC_1024 4507-0395 4.23 26.0 µM 2.76E-6 TSC3-RPN4 20 1.15E-5
9 SGTC_2769 toremifene 4.07 3.7 µM 6.15E-6 20 2.32E-5
10 SGTC_2228 7354201 4.07 200.0 µM 6.19E-6 endomembrane recycling 2 2.33E-5
11 SGTC_747 3448-8087 3.96 38.7 µM 1.08E-5 25 3.82E-5
12 SGTC_2258 7960471 3.94 200.0 µM 1.14E-5 9 4.01E-5
13 SGTC_2330 7979373 3.73 200.0 µM 3.13E-5 60S ribosome export 42 9.73E-5
14 SGTC_1829 berberine 3.69 14.4 µM 3.70E-5 60S ribosome export 24 1.13E-4
15 SGTC_1564 D-Arginine 3.61 115.0 µM 5.31E-5 39 1.55E-4
16 SGTC_537 1334-0398 3.61 209.0 µM 5.33E-5 38 1.55E-4
17 SGTC_2099 5377090 3.56 177.4 µM 6.50E-5 37 1.85E-4
18 SGTC_1079 idarubicin 3.53 2.4 µM 7.37E-5 DNA damage response 32 2.07E-4
19 SGTC_604 1000-0114 3.51 314.0 µM 8.03E-5 39 2.23E-4
20 SGTC_2253 7938677 3.40 135.8 µM 1.30E-4 26 3.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.42E-14 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.117 8.57E-12 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.108 4.13E-10 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.103 2.59E-9 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.096 2.72E-8 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.094 5.26E-8 YML006C GIS4 hom CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
0.087 4.86E-7 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.086 6.05E-7 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.084 1.13E-6 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.080 3.43E-6 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.078 6.66E-6 YKL006W RPL14A hom Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication
0.075 1.22E-5 YJL038C LOH1 hom Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
0.074 1.87E-5 YLR340W RPP0 het Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
0.074 1.96E-5 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.074 1.96E-5 YIL152W_p YIL152W_p hom Putative protein of unknown function