HIPHOP chemogenomics database
YLR227C / ADY4 
Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YLR227C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.130 | 3.42E-14 | YKL220C | FRE2 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels |
| 0.117 | 8.57E-12 | YBR205W | KTR3 | hom | Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress |
| 0.108 | 4.13E-10 | YGL263W | COS12 | hom | Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
| 0.103 | 2.59E-9 | YGL051W | MST27 | hom | Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles |
| 0.096 | 2.72E-8 | YBR153W | RIB7 | het | Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway |
| 0.094 | 5.26E-8 | YML006C | GIS4 | hom | CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway |
| 0.087 | 4.86E-7 | YDR046C | BAP3 | hom | Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication |
| 0.086 | 6.05E-7 | YGR182C_d | YGR182C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W |
| 0.084 | 1.13E-6 | YDR043C | NRG1 | hom | Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication |
| 0.080 | 3.43E-6 | YDR329C | PEX3 | hom | Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p |
| 0.078 | 6.66E-6 | YKL006W | RPL14A | hom | Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication |
| 0.075 | 1.22E-5 | YJL038C | LOH1 | hom | Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 |
| 0.074 | 1.87E-5 | YLR340W | RPP0 | het | Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 |
| 0.074 | 1.96E-5 | YGL248W | PDE1 | hom | Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation |
| 0.074 | 1.96E-5 | YIL152W_p | YIL152W_p | hom | Putative protein of unknown function |