YLR247C / IRC20

Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR247C / IRC20

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:3.03|P-value:3.69E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:2.86|P-value:7.34E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.68|P-value:2.46E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:2.94|P-value:5.24E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.64|P-value:2.58E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:2.79|P-value:9.49E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.48|P-value:5.56E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.11|P-value:2.99E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.33|P-value:1.23E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-2.98|P-value:5.18E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.64|P-value:1.24E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.86|P-value:7.21E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.73|P-value:7.63E-8 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.41|P-value:7.38E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:-2.90|P-value:6.94E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.19|P-value:1.93E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.34|P-value:9.96E-5 ID:SGTC_1763|Compound:st044482|FD-Score:-3.16|P-value:2.48E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.01|P-value:3.99E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.33|P-value:1.08E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.10|P-value:2.86E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.85|P-value:7.62E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.43|P-value:6.97E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:2.89|P-value:6.43E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.54|P-value:4.17E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.36|P-value:9.31E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.16|P-value:2.16E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.20|P-value:1.83E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.94|P-value:5.89E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:3.03|P-value:3.69E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:2.86|P-value:7.34E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.68|P-value:2.46E-5 ID:SGTC_508|Compound:roscovitine|FD-Score:2.94|P-value:5.24E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.64|P-value:2.58E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:2.79|P-value:9.49E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.48|P-value:5.56E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.11|P-value:2.99E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.33|P-value:1.23E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-2.98|P-value:5.18E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.64|P-value:1.24E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.86|P-value:7.21E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.73|P-value:7.63E-8 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.41|P-value:7.38E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:-2.90|P-value:6.94E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.19|P-value:1.93E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.34|P-value:9.96E-5 ID:SGTC_1763|Compound:st044482|FD-Score:-3.16|P-value:2.48E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.01|P-value:3.99E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.33|P-value:1.08E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.10|P-value:2.86E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.85|P-value:7.62E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.43|P-value:6.97E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:2.89|P-value:6.43E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.54|P-value:4.17E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.36|P-value:9.31E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.16|P-value:2.16E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.20|P-value:1.83E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.94|P-value:5.89E-6

Top fitness defect scores for YLR247C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1132 3456-3614 4.73 2.5 µM 7.63E-8 tubulin folding & SWR complex 20 1.15E-6
2 SGTC_1056 3448-1962 4.64 115.0 µM 1.24E-7 amide catabolism 13 1.71E-6
3 SGTC_3272 9137413 3.94 49.5 µM 5.89E-6 13 4.04E-5
4 SGTC_615 k087-0205 3.64 167.0 µM 2.58E-5 16 1.36E-4
5 SGTC_2887 9044784 3.54 58.4 µM 4.17E-5 fatty acid desaturase (OLE1) 50 2.01E-4
6 SGTC_821 1114-0266 3.48 29.2 µM 5.56E-5 35 2.55E-4
7 SGTC_2755 lomerizine 3.43 42.7 µM 6.97E-5 41 3.07E-4
8 SGTC_1181 1222-0449 3.41 220.0 µM 7.38E-5 41 3.22E-4
9 SGTC_3136 9095672 3.36 49.5 µM 9.31E-5 49 3.90E-4
10 SGTC_1362 1611-0397 3.34 101.0 µM 9.96E-5 39 4.12E-4
11 SGTC_2102 5377816 3.33 72.8 µM 1.08E-4 42 4.40E-4
12 SGTC_3268 9137683 3.20 49.5 µM 1.83E-4 25 6.81E-4
13 SGTC_1348 1493-0373 3.19 93.8 µM 1.93E-4 37 7.10E-4
14 SGTC_3235 9132602 3.16 49.5 µM 2.16E-4 65 7.80E-4
15 SGTC_2173 5763948 3.10 167.0 µM 2.86E-4 tubulin folding & SWR complex 44 9.82E-4
16 SGTC_99 0109-0120 3.03 622.8 µM 3.69E-4 50 0.00121
17 SGTC_1767 st044992 3.01 70.3 µM 3.99E-4 60 0.00129
18 SGTC_508 roscovitine 2.94 141.0 µM 5.24E-4 29 0.00162
19 SGTC_2759 disulfiram 2.89 3.4 µM 6.43E-4 90 0.00191
20 SGTC_1112 tnp00069 2.86 1.2 µM 7.21E-4 79 0.00210

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.34E-17 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.112 6.73E-11 YBR094W PBY1 hom Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress
0.104 1.76E-9 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.102 3.46E-9 YLR300W EXG1 hom Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
0.099 7.72E-9 YCR073W-A SOL2 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication
0.093 6.25E-8 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.091 1.10E-7 YOR285W RDL1 hom Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
0.086 5.44E-7 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.084 1.26E-6 YBR124W_d YBR124W_d het Putative protein of unknown function
0.082 1.81E-6 YGR026W_p YGR026W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.082 2.16E-6 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.081 2.40E-6 YFR018C_p YFR018C_p hom Putative protein of unknown function
0.081 2.75E-6 YOR367W SCP1 hom Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
0.081 2.82E-6 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.078 6.79E-6 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination