YLR259C / HSP60

Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR259C / HSP60

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-2.82|P-value:6.14E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.60|P-value:1.77E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.20|P-value:4.14E-13 ID:SGTC_284|Compound:0988-0104|FD-Score:3.37|P-value:4.97E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.80|P-value:5.70E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:2.73|P-value:7.85E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.32|P-value:6.28E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.40|P-value:4.20E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.65|P-value:4.74E-8 ID:SGTC_756|Compound:0508-1999|FD-Score:2.98|P-value:2.90E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-2.73|P-value:8.77E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.49|P-value:3.09E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.76|P-value:6.99E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.52|P-value:2.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-4.45|P-value:1.57E-7 ID:SGTC_918|Compound:glabranin|FD-Score:-3.22|P-value:1.12E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.48|P-value:3.31E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.86|P-value:4.12E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.96|P-value:5.11E-9 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.55|P-value:2.08E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:2.95|P-value:3.20E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:4.62E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.69|P-value:9.41E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.33|P-value:6.58E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.68|P-value:9.80E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.95|P-value:3.61E-4 ID:SGTC_1686|Compound:st019653|FD-Score:2.81|P-value:5.80E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.95|P-value:3.25E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-4.01|P-value:2.11E-6 ID:SGTC_1847|Compound:st056231|FD-Score:-2.77|P-value:7.60E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-2.92|P-value:4.10E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.42|P-value:3.92E-5 ID:SGTC_2161|Compound:5662504|FD-Score:-2.76|P-value:7.68E-4 ID:SGTC_2311|Compound:7694451|FD-Score:2.81|P-value:5.73E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.81|P-value:5.68E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.18|P-value:7.01E-7 ID:SGTC_2814|Compound:7977482|FD-Score:4.21|P-value:5.86E-7 ID:SGTC_2829|Compound:7992743|FD-Score:3.55|P-value:2.03E-5 ID:SGTC_2851|Compound:9015922|FD-Score:2.68|P-value:9.51E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.00|P-value:2.88E-4 ID:SGTC_3024|Compound:9090631|FD-Score:2.91|P-value:3.85E-4 ID:SGTC_3226|Compound:9131256|FD-Score:2.82|P-value:5.47E-4 ID:SGTC_3237|Compound:9133362|FD-Score:2.70|P-value:8.79E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.14|P-value:1.44E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-2.82|P-value:6.14E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.60|P-value:1.77E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.20|P-value:4.14E-13 ID:SGTC_284|Compound:0988-0104|FD-Score:3.37|P-value:4.97E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.80|P-value:5.70E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:2.73|P-value:7.85E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.32|P-value:6.28E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.40|P-value:4.20E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.65|P-value:4.74E-8 ID:SGTC_756|Compound:0508-1999|FD-Score:2.98|P-value:2.90E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-2.73|P-value:8.77E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.49|P-value:3.09E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.76|P-value:6.99E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.52|P-value:2.41E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-4.45|P-value:1.57E-7 ID:SGTC_918|Compound:glabranin|FD-Score:-3.22|P-value:1.12E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.48|P-value:3.31E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.86|P-value:4.12E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.96|P-value:5.11E-9 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.55|P-value:2.08E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:2.95|P-value:3.20E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.38|P-value:4.62E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.69|P-value:9.41E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.33|P-value:6.58E-5 ID:SGTC_1630|Compound:st005209|FD-Score:2.68|P-value:9.80E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.95|P-value:3.61E-4 ID:SGTC_1686|Compound:st019653|FD-Score:2.81|P-value:5.80E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:2.95|P-value:3.25E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-4.01|P-value:2.11E-6 ID:SGTC_1847|Compound:st056231|FD-Score:-2.77|P-value:7.60E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-2.92|P-value:4.10E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.42|P-value:3.92E-5 ID:SGTC_2161|Compound:5662504|FD-Score:-2.76|P-value:7.68E-4 ID:SGTC_2311|Compound:7694451|FD-Score:2.81|P-value:5.73E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.81|P-value:5.68E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.18|P-value:7.01E-7 ID:SGTC_2814|Compound:7977482|FD-Score:4.21|P-value:5.86E-7 ID:SGTC_2829|Compound:7992743|FD-Score:3.55|P-value:2.03E-5 ID:SGTC_2851|Compound:9015922|FD-Score:2.68|P-value:9.51E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.00|P-value:2.88E-4 ID:SGTC_3024|Compound:9090631|FD-Score:2.91|P-value:3.85E-4 ID:SGTC_3226|Compound:9131256|FD-Score:2.82|P-value:5.47E-4 ID:SGTC_3237|Compound:9133362|FD-Score:2.70|P-value:8.79E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.14|P-value:1.44E-4

Top fitness defect scores for YLR259C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_120 rhodamine 6G 6.20 52.3 µM 4.14E-13 mitochondrial processes 4 2.79E-10 0.11
2 SGTC_1248 0469-0687 4.96 58.6 µM 5.11E-9 5 3.51E-7 0.28
3 SGTC_2814 7977482 4.21 43.0 µM 5.86E-7 10 1.29E-5 0.11
4 SGTC_2794 7785382 4.18 27.3 µM 7.01E-7 12 1.47E-5 0.17
5 SGTC_1136 pergolide 3.86 1.1 µM 4.12E-6 21 5.68E-5 0.10
6 SGTC_321 4534-3890 3.80 65.3 µM 5.70E-6 RPP1 & pyrimidine depletion 8 7.27E-5 0.11
7 SGTC_2829 7992743 3.55 58.4 µM 2.03E-5 9 1.92E-4 0.08
8 SGTC_1450 4112-4260 3.55 37.6 µM 2.08E-5 calcium & mitochondrial duress 8 1.95E-4 0.27
9 SGTC_861 0443-0273 3.52 110.0 µM 2.41E-5 5 2.18E-4 0.22
10 SGTC_2103 5378138 3.42 10.0 µM 3.92E-5 4 3.17E-4 0.18
11 SGTC_740 k014-0057 3.40 261.0 µM 4.20E-5 6 3.33E-4 0.02
12 SGTC_1521 st012942 3.38 49.4 µM 4.62E-5 7 3.59E-4 0.00
13 SGTC_284 0988-0104 3.37 32.6 µM 4.97E-5 heme requiring 5 3.80E-4 0.18
14 SGTC_358 0075-0058 3.32 9.4 µM 6.28E-5 16 4.54E-4 0.02
15 SGTC_3305 9127027 3.14 53.8 µM 1.44E-4 13 8.54E-4 0.01
16 SGTC_756 0508-1999 2.98 28.3 µM 2.90E-4 RPP1 & pyrimidine depletion 22 0.00146 0.01
17 SGTC_1506 4226-2149 2.95 212.0 µM 3.20E-4 15 0.00158 0.03
18 SGTC_1698 5-fluorocytosine 2.95 1.1 µM 3.25E-4 exosome 27 0.00160 0.04
19 SGTC_3024 9090631 2.91 49.5 µM 3.85E-4 9 0.00182 0.02
20 SGTC_3226 9131256 2.82 49.5 µM 5.47E-4 5 0.00238 0.28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 5.94E-37 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.216 1.04E-36 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.206 1.29E-33 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.204 9.69E-33 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.197 1.05E-30 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.196 1.52E-30 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.188 4.24E-28 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.179 1.41E-25 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.175 1.98E-24 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.171 2.15E-23 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.170 3.00E-23 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.166 3.65E-22 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.166 4.39E-22 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.164 9.87E-22 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.163 1.64E-21 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data