YLR260W / LCB5

Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR260W / LCB5

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.30|P-value:2.27E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.47|P-value:5.52E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.92|P-value:3.53E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.11|P-value:1.13E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:6.20|P-value:4.19E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.74|P-value:2.10E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.69|P-value:2.54E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.53|P-value:4.58E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:3.69|P-value:7.19E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.22|P-value:3.57E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:6.39|P-value:1.62E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:3.84|P-value:4.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.60|P-value:3.19E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.60|P-value:3.47E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:14.50|P-value:1.76E-36 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.92|P-value:3.57E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.65|P-value:7.87E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.00|P-value:7.76E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:3.99|P-value:2.81E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.84|P-value:4.47E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.67|P-value:2.74E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:4.08|P-value:2.13E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.27|P-value:2.62E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.54|P-value:4.38E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.65|P-value:7.96E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.96|P-value:8.98E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.91|P-value:3.50E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.09|P-value:5.49E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.92|P-value:3.36E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.47|P-value:1.11E-6 ID:SGTC_1922|Compound:5578187|FD-Score:5.12|P-value:4.77E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-4.12|P-value:1.79E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.66|P-value:7.50E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.21|P-value:1.39E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.81|P-value:2.48E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.86|P-value:1.31E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.59|P-value:9.64E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.06|P-value:2.14E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.67|P-value:7.69E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.70|P-value:7.01E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.59|P-value:9.49E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.93|P-value:3.44E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.61|P-value:9.00E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.68|P-value:7.19E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-5.04|P-value:6.23E-6 ID:SGTC_2919|Compound:7978188|FD-Score:-6.22|P-value:3.63E-8 ID:SGTC_2920|Compound:7982904|FD-Score:-4.98|P-value:8.03E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.65|P-value:2.84E-5 ID:SGTC_2955|Compound:9076254|FD-Score:-3.62|P-value:8.41E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-5.30|P-value:2.18E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-3.79|P-value:5.09E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.30|P-value:2.27E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.47|P-value:5.52E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.92|P-value:3.53E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.11|P-value:1.13E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:6.20|P-value:4.19E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:4.74|P-value:2.10E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.69|P-value:2.54E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.53|P-value:4.58E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:3.69|P-value:7.19E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-6.22|P-value:3.57E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:6.39|P-value:1.62E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:3.84|P-value:4.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.60|P-value:3.19E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.60|P-value:3.47E-20 ID:SGTC_310|Compound:1273-0058|FD-Score:14.50|P-value:1.76E-36 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.92|P-value:3.57E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.65|P-value:7.87E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.00|P-value:7.76E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:3.99|P-value:2.81E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.84|P-value:4.47E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.67|P-value:2.74E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:4.08|P-value:2.13E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.27|P-value:2.62E-6 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.54|P-value:4.38E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.65|P-value:7.96E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.96|P-value:8.98E-6 ID:SGTC_1707|Compound:st032323|FD-Score:-3.91|P-value:3.50E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.09|P-value:5.49E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.92|P-value:3.36E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.47|P-value:1.11E-6 ID:SGTC_1922|Compound:5578187|FD-Score:5.12|P-value:4.77E-6 ID:SGTC_2065|Compound:5221596|FD-Score:-4.12|P-value:1.79E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.66|P-value:7.50E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.21|P-value:1.39E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.81|P-value:2.48E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.86|P-value:1.31E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.59|P-value:9.64E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.06|P-value:2.14E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.67|P-value:7.69E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.70|P-value:7.01E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.59|P-value:9.49E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.93|P-value:3.44E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.61|P-value:9.00E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.68|P-value:7.19E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-5.04|P-value:6.23E-6 ID:SGTC_2919|Compound:7978188|FD-Score:-6.22|P-value:3.63E-8 ID:SGTC_2920|Compound:7982904|FD-Score:-4.98|P-value:8.03E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-4.65|P-value:2.84E-5 ID:SGTC_2955|Compound:9076254|FD-Score:-3.62|P-value:8.41E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-5.30|P-value:2.18E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-3.79|P-value:5.09E-4

Top fitness defect scores for YLR260W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 14.50 1.1 µM 1.76E-36 mitochondrial stress 9 4.69E-48
2 SGTC_236 1509-0011 10.60 5.3 µM 3.19E-20 186 2.20E-26
3 SGTC_275 trichlorophene 10.60 5.7 µM 3.47E-20 mitochondrial stress 38 2.45E-26
4 SGTC_63 0099-0242 8.11 26.7 µM 1.13E-12 mitochondrial stress 9 2.46E-16
5 SGTC_173 1273-0061 6.39 2.7 µM 1.62E-8 mitochondrial stress 101 8.16E-11
6 SGTC_70 0141-0289 6.20 43.3 µM 4.19E-8 mitochondrial stress 75 2.88E-10
7 SGTC_2232 chlorophetanol 5.81 41.5 µM 2.48E-7 TRP & mitochondrial translation 44 3.03E-9
8 SGTC_1839 st053978 5.47 48.0 µM 1.11E-6 1 2.21E-8
9 SGTC_10 0279-0212 5.30 42.6 µM 2.27E-6 TRP & mitochondrial translation 46 5.68E-8
10 SGTC_1036 k216-0215 5.27 33.5 µM 2.62E-6 mitochondrial response to ROS 22 6.86E-8
11 SGTC_1922 5578187 5.12 25.0 µM 4.77E-6 TRP & mitochondrial translation 8 1.52E-7
12 SGTC_1742 st038235 5.09 28.9 µM 5.49E-6 mitochondrial stress 72 1.83E-7
13 SGTC_625 k213-0058 5.00 121.0 µM 7.76E-6 translation 57 2.89E-7
14 SGTC_1627 st003713 4.96 25.6 µM 8.98E-6 calcium & mitochondrial duress 42 3.51E-7
15 SGTC_2250 alverine citrate 4.86 130.0 µM 1.31E-5 99 5.76E-7
16 SGTC_118 0083-0097 4.74 135.3 µM 2.10E-5 translation 74 1.07E-6
17 SGTC_119 0121-0043 4.69 24.8 µM 2.54E-5 mitochondrial stress 70 1.39E-6
18 SGTC_832 4083-0019 4.67 164.0 µM 2.74E-5 translation 53 1.53E-6
19 SGTC_1284 0929-0043 4.54 16.0 µM 4.38E-5 15 2.84E-6
20 SGTC_120 rhodamine 6G 4.53 52.3 µM 4.58E-5 mitochondrial processes 18 3.02E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.472 4.32E-185 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.464 2.49E-178 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.457 8.69E-172 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.451 7.45E-167 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.440 1.90E-158 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.440 3.78E-158 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.440 5.51E-158 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.437 1.28E-155 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.431 2.73E-151 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.427 1.39E-148 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.425 4.02E-147 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.425 1.89E-146 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.423 2.71E-145 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.423 4.59E-145 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.422 1.78E-144 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)