HIPHOP chemogenomics database

YLR267W_p / BOP2

Protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR267W / BOP2

Click on Significant Values for Screen Details

Top fitness defect scores for YLR267W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1725	st036284	4.73	20.6 µM	2.32E-9		17	1.13E-6
2	SGTC_2722	naftopidil	4.56	47.2 µM	7.77E-9		3	2.52E-6
3	SGTC_1520	flindersine	4.47	88.0 µM	1.52E-8		20	3.93E-6
4	SGTC_2135	5326629	4.39	150.4 µM	2.67E-8	RPP1 & pyrimidine depletion	17	5.72E-6
5	SGTC_2913	7966556	4.21	36.6 µM	9.01E-8	60S ribosome export	5	1.28E-5
6	SGTC_8	0354-0001	3.98	70.0 µM	3.86E-7		76	3.38E-5
7	SGTC_2930	9013230	3.88	14.9 µM	7.62E-7	heme biosynthesis & mitochondrial translocase	40	5.31E-5
8	SGTC_2724	maprotiline	3.76	69.6 µM	1.59E-6	ERG2	19	8.66E-5
9	SGTC_2835	9006588	3.54	71.4 µM	5.71E-6		58	2.04E-4
10	SGTC_2924	9010168	3.05	62.8 µM	7.44E-5	cell wall signaling	80	0.00113
11	SGTC_2133	5320837	3.00	200.0 µM	9.48E-5	ERG2	72	0.00134
12	SGTC_2885	9057732	2.99	52.0 µM	9.94E-5		49	0.00138
13	SGTC_356	1634-0012	2.95	32.5 µM	1.23E-4		74	0.00159
14	SGTC_2242	6630449	2.95	61.3 µM	1.24E-4	Golgi	82	0.00160
15	SGTC_3262	9137218	2.93	49.5 µM	1.37E-4		19	0.00171
16	SGTC_2014	4013930	2.92	200.0 µM	1.42E-4		94	0.00176
17	SGTC_1123	mangostin	2.87	811.3 nM	1.76E-4	mitochondrial response to ROS	92	0.00202
18	SGTC_2563	tomatine	2.87	8.5 µM	1.78E-4		129	0.00204
19	SGTC_3281	9140613	2.82	49.5 µM	2.28E-4	RPP1 & pyrimidine depletion	72	0.00241
20	SGTC_3066	9117245	2.80	49.5 µM	2.48E-4		68	0.00255

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.241	9.80E-46	YHR003C	YHR003C	hom	Protein of unknown function, localized to the mitochondrial outer membrane
0.237	4.56E-44	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.221	2.80E-38	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.221	2.71E-38	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.218	2.65E-37	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.215	1.47E-36	YEL049W	PAU2	hom	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.214	3.87E-36	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.213	1.04E-35	YEL004W	YEA4	hom	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.203	1.63E-32	YKR023W_p	YKR023W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.202	2.29E-32	YGR032W	GSC2	hom	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.199	2.59E-31	YDR110W	FOB1	hom	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.198	4.73E-31	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198	7.53E-31	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.195	4.22E-30	YLR353W	BUD8	hom	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.194	6.86E-30	YBR118W	TEF2	hom	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication