YLR283W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR283W / YLR283W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.87|P-value:2.05E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:3.38|P-value:1.66E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.09|P-value:7.21E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:3.20|P-value:3.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.05|P-value:6.84E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.00|P-value:1.10E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:2.92|P-value:9.68E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.08|P-value:6.13E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-6.08|P-value:7.59E-11 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.11|P-value:5.42E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.20|P-value:5.18E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.18|P-value:4.27E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.51|P-value:1.15E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.05|P-value:6.06E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-2.99|P-value:8.42E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.28|P-value:2.81E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.32|P-value:2.42E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.55|P-value:7.08E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.31|P-value:2.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.33|P-value:5.80E-15 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.13|P-value:4.36E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:2.94|P-value:9.07E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.55|P-value:8.08E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.01|P-value:6.91E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.58|P-value:7.14E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.57|P-value:8.91E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.16|P-value:4.51E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.00|P-value:7.27E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.49|P-value:1.25E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.63|P-value:4.71E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-4.05|P-value:1.05E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-8.44|P-value:3.07E-19 ID:SGTC_2244|Compound:6635614|FD-Score:-6.68|P-value:9.93E-13 ID:SGTC_2259|Compound:7964009|FD-Score:5.28|P-value:1.14E-8 ID:SGTC_2278|Compound:7948257|FD-Score:3.71|P-value:4.11E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.05|P-value:6.05E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_2372|Compound:9071633|FD-Score:4.64|P-value:4.42E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.30|P-value:2.31E-4 ID:SGTC_2460|Compound:5552655|FD-Score:2.96|P-value:8.26E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.74|P-value:3.58E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.96|P-value:7.27E-8 ID:SGTC_2909|Compound:7941780|FD-Score:3.39|P-value:1.61E-4 ID:SGTC_2916|Compound:7875993|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-4.70|P-value:3.87E-7 ID:SGTC_3153|Compound:9100258|FD-Score:-2.95|P-value:9.85E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.38|P-value:1.97E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.11|P-value:4.76E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.83|P-value:2.46E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.52|P-value:9.37E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.24|P-value:3.39E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.98|P-value:1.19E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-4.82|P-value:1.95E-7 ID:SGTC_6|Compound:0844-0013|FD-Score:3.87|P-value:2.05E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:3.38|P-value:1.66E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.09|P-value:7.21E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:3.20|P-value:3.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.05|P-value:6.84E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.00|P-value:1.10E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:2.92|P-value:9.68E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.08|P-value:6.13E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-6.08|P-value:7.59E-11 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.11|P-value:5.42E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.20|P-value:5.18E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.18|P-value:4.27E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.51|P-value:1.15E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.05|P-value:6.06E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-2.99|P-value:8.42E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.28|P-value:2.81E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.32|P-value:2.42E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:4.55|P-value:7.08E-7 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.31|P-value:2.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.33|P-value:5.80E-15 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.13|P-value:4.36E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:2.94|P-value:9.07E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.55|P-value:8.08E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.01|P-value:6.91E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.58|P-value:7.14E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.57|P-value:8.91E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.16|P-value:4.51E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.00|P-value:7.27E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.49|P-value:1.25E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.63|P-value:4.71E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-4.05|P-value:1.05E-5 ID:SGTC_2240|Compound:6690706|FD-Score:-8.44|P-value:3.07E-19 ID:SGTC_2244|Compound:6635614|FD-Score:-6.68|P-value:9.93E-13 ID:SGTC_2259|Compound:7964009|FD-Score:5.28|P-value:1.14E-8 ID:SGTC_2278|Compound:7948257|FD-Score:3.71|P-value:4.11E-5 ID:SGTC_2282|Compound:7944268|FD-Score:3.05|P-value:6.05E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_2372|Compound:9071633|FD-Score:4.64|P-value:4.42E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.30|P-value:2.31E-4 ID:SGTC_2460|Compound:5552655|FD-Score:2.96|P-value:8.26E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.74|P-value:3.58E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.96|P-value:7.27E-8 ID:SGTC_2909|Compound:7941780|FD-Score:3.39|P-value:1.61E-4 ID:SGTC_2916|Compound:7875993|FD-Score:2.97|P-value:8.01E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-4.70|P-value:3.87E-7 ID:SGTC_3153|Compound:9100258|FD-Score:-2.95|P-value:9.85E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.38|P-value:1.97E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.11|P-value:4.76E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.83|P-value:2.46E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.52|P-value:9.37E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.24|P-value:3.39E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.98|P-value:1.19E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-4.82|P-value:1.95E-7

Top fitness defect scores for YLR283W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2259 7964009 5.28 200.0 µM 1.14E-8 superoxide 17 6.60E-8
2 SGTC_2787 5284540 4.96 71.4 µM 7.27E-8 9 3.49E-7
3 SGTC_2372 9071633 4.64 200.0 µM 4.42E-7 6 1.76E-6
4 SGTC_2237 6667747 4.63 47.2 µM 4.71E-7 9 1.86E-6
5 SGTC_1073 triclabendazole 4.55 3.1 µM 7.08E-7 18 2.69E-6
6 SGTC_945 3381-0768 4.28 11.3 µM 2.81E-6 endomembrane recycling 27 9.26E-6
7 SGTC_73 0327-0325 4.09 16.2 µM 7.21E-6 DNA damage response 46 2.16E-5
8 SGTC_173 1273-0061 4.00 2.7 µM 1.10E-5 mitochondrial stress 184 3.14E-5
9 SGTC_3336 9143619 3.98 71.4 µM 1.19E-5 20 3.38E-5
10 SGTC_6 0844-0013 3.87 19.8 µM 2.05E-5 96 5.53E-5
11 SGTC_3208 9114115 3.83 49.5 µM 2.46E-5 42 6.49E-5
12 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.74 3.7 µM 3.58E-5 101 9.10E-5
13 SGTC_2278 7948257 3.71 134.3 µM 4.11E-5 27 1.03E-4
14 SGTC_1521 st012942 3.58 49.4 µM 7.14E-5 43 1.69E-4
15 SGTC_1175 0741-0056 3.55 27.6 µM 8.08E-5 34 1.89E-4
16 SGTC_3215 9129942 3.52 49.5 µM 9.37E-5 20 2.16E-4
17 SGTC_2909 7941780 3.39 10.5 µM 1.61E-4 41 3.51E-4
18 SGTC_12 0849-0099 3.38 9.3 µM 1.66E-4 32 3.61E-4
19 SGTC_2004 4023728 3.36 41.9 µM 1.78E-4 51 3.85E-4
20 SGTC_2421 5690543 3.30 90.7 µM 2.31E-4 41 4.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 3.25E-34 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.176 9.81E-25 YLR267W_p BOP2_p hom Protein of unknown function
0.167 2.73E-22 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.166 3.33E-22 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.161 7.28E-21 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.155 1.50E-19 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.153 4.28E-19 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.153 6.57E-19 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.151 1.59E-18 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.149 4.70E-18 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.145 2.73E-17 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.145 3.30E-17 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.142 1.22E-16 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.142 1.31E-16 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.142 1.34E-16 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7