HIPHOP chemogenomics database
YLR287C_p 
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR287C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.145 | 2.38E-17 | YDR306C_p | YDR306C_p | hom | F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain |
| 0.118 | 7.67E-12 | YLR394W | CST9 | hom | SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate |
| 0.107 | 4.65E-10 | YGR201C_p | YGR201C_p | hom | Putative protein of unknown function |
| 0.106 | 8.57E-10 | YPL012W | RRP12 | het | Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats |
| 0.101 | 3.96E-9 | YBL002W | HTB2 | hom | Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation |
| 0.092 | 8.80E-8 | YML007C-A_p | YML007C-A_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria |
| 0.091 | 1.17E-7 | YMR059W | SEN15 | het | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p |
| 0.090 | 1.93E-7 | YKL030W_d | YKL030W_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1 |
| 0.089 | 2.24E-7 | YFR017C | IGD1 | hom | Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication |
| 0.089 | 2.80E-7 | YKL094W | YJU3 | hom | Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family |
| 0.088 | 3.18E-7 | YDL239C | ADY3 | hom | Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication |
| 0.083 | 1.29E-6 | YGR058W | PEF1 | hom | Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly |
| 0.082 | 1.98E-6 | YML086C | ALO1 | hom | D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress |
| 0.081 | 2.31E-6 | YKL172W | EBP2 | het | Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering |
| 0.081 | 2.72E-6 | YDR142C | PEX7 | hom | Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) |