HIPHOP chemogenomics database

YLR307C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR307C-A / YLR307C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YLR307C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2625	euphol	6.46	100.0 µM	6.60E-13		3	5.37E-11
2	SGTC_3217	9129673	6.26	49.5 µM	3.08E-12		5	1.93E-10
3	SGTC_2519	cryptotanshinone	3.98	88.0 µM	6.08E-6	heme biosynthesis & mitochondrial translocase	13	3.41E-5
4	SGTC_359	0081-0058	3.86	15.9 µM	1.10E-5	60S ribosome export	45	5.61E-5
5	SGTC_2303	7774051	3.72	200.0 µM	2.22E-5		26	1.01E-4
6	SGTC_236	1509-0011	3.59	5.3 µM	3.93E-5		408	1.62E-4
7	SGTC_3043	9092303	3.57	49.5 µM	4.36E-5		30	1.77E-4
8	SGTC_2621	lithochol-11-enic acid	3.50	100.0 µM	6.06E-5		42	2.33E-4
9	SGTC_2295	7971645	3.49	200.0 µM	6.19E-5		38	2.37E-4
10	SGTC_1447	4239-0816	3.45	81.9 µM	7.43E-5		51	2.77E-4
11	SGTC_402	epigallocatechin gallate	3.45	10.0 µM	7.65E-5		52	2.83E-4
12	SGTC_2109	5483026	3.44	200.0 µM	7.82E-5	RSC complex & mRNA processing	46	2.89E-4
13	SGTC_2299	7976368	3.40	114.9 µM	9.31E-5		50	3.34E-4
14	SGTC_3038	9091290	3.38	49.5 µM	1.02E-4		34	3.61E-4
15	SGTC_243	5hr heat shock (37°C) + splitomicin	3.36	1.0 µM	1.11E-4	heat shock/prefoldin	78	3.87E-4
16	SGTC_2453	5731132	3.25	22.2 µM	1.75E-4		52	5.67E-4
17	SGTC_1810	st050138	3.25	53.0 µM	1.82E-4	PDR1	28	5.86E-4
18	SGTC_2166	5933061	3.23	31.5 µM	1.97E-4	tubulin folding & SWR complex	71	6.26E-4
19	SGTC_2937	9044753	3.23	11.3 µM	1.98E-4	60S ribosome export	66	6.28E-4
20	SGTC_1206	3978-0017	3.14	132.0 µM	2.86E-4	ERG2	62	8.56E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.169	6.13E-23	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.161	5.91E-21	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.153	5.11E-19	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.127	1.79E-13	YGR174C	CBP4	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.126	2.95E-13	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.123	1.01E-12	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.121	2.21E-12	YNL260C	LTO1	het	Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.120	2.86E-12	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.120	2.89E-12	YBR085C-A	YBR085C-A	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.119	4.97E-12	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.118	7.95E-12	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.116	1.59E-11	YOR125C	CAT5	hom	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.113	5.93E-11	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111	1.23E-10	YPR147C_p	YPR147C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
0.109	2.74E-10	YGL210W	YPT32	hom	Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication