YLR317W_d

Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR317W / YLR317W

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:7.34E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.91|P-value:1.94E-11 ID:SGTC_84|Compound:0443-0269|FD-Score:4.36|P-value:5.51E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:2.87|P-value:6.85E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.92|P-value:5.59E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.79|P-value:4.50E-8 ID:SGTC_135|Compound:0933-0004|FD-Score:4.49|P-value:2.74E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:3.43|P-value:6.42E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.76|P-value:9.92E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:2.78|P-value:9.48E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.94|P-value:5.23E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:4.11|P-value:2.21E-6 ID:SGTC_303|Compound:1348-1668|FD-Score:3.01|P-value:3.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.89|P-value:6.14E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.93|P-value:5.74E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.55|P-value:3.58E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.02|P-value:3.72E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.82|P-value:9.81E-6 ID:SGTC_674|Compound:0498-0004|FD-Score:3.66|P-value:2.17E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.84|P-value:1.93E-28 ID:SGTC_763|Compound:3453-1109|FD-Score:3.81|P-value:1.05E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:2.83|P-value:7.81E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.44|P-value:6.22E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:2.86|P-value:7.10E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.75|P-value:1.42E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:2.81|P-value:8.66E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.89|P-value:6.39E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.88|P-value:6.66E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:2.94|P-value:5.23E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.57|P-value:1.60E-7 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.10|P-value:2.38E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.41|P-value:6.98E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.84|P-value:3.24E-8 ID:SGTC_1531|Compound:st059297|FD-Score:3.21|P-value:1.69E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:2.93|P-value:5.35E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.67|P-value:2.07E-5 ID:SGTC_1634|Compound:st006576|FD-Score:4.49|P-value:2.65E-7 ID:SGTC_1714|Compound:st033236|FD-Score:4.85|P-value:2.98E-8 ID:SGTC_1850|Compound:st056238|FD-Score:-2.85|P-value:7.13E-4 ID:SGTC_2213|Compound:7173844|FD-Score:-2.97|P-value:4.46E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.85|P-value:3.09E-8 ID:SGTC_2335|Compound:9018011|FD-Score:3.49|P-value:5.02E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.76|P-value:5.19E-8 ID:SGTC_2426|Compound:5582046|FD-Score:-3.27|P-value:1.24E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.87|P-value:2.70E-8 ID:SGTC_2445|Compound:5742597|FD-Score:-3.65|P-value:2.23E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.56|P-value:3.51E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:2.98|P-value:4.49E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.17|P-value:1.93E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.18|P-value:1.82E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.54|P-value:2.02E-7 ID:SGTC_2707|Compound:st078556|FD-Score:4.22|P-value:1.26E-6 ID:SGTC_2714|Compound:st079313|FD-Score:-3.36|P-value:8.26E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.77|P-value:9.48E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-2.92|P-value:5.40E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.97|P-value:4.48E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.18|P-value:1.88E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-2.88|P-value:6.26E-4 ID:SGTC_3212|Compound:9128307|FD-Score:2.99|P-value:4.30E-4 ID:SGTC_3214|Compound:9129694|FD-Score:2.83|P-value:7.93E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:7.34E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.91|P-value:1.94E-11 ID:SGTC_84|Compound:0443-0269|FD-Score:4.36|P-value:5.51E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:2.87|P-value:6.85E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.92|P-value:5.59E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.79|P-value:4.50E-8 ID:SGTC_135|Compound:0933-0004|FD-Score:4.49|P-value:2.74E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:3.43|P-value:6.42E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.76|P-value:9.92E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:2.78|P-value:9.48E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.94|P-value:5.23E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:4.11|P-value:2.21E-6 ID:SGTC_303|Compound:1348-1668|FD-Score:3.01|P-value:3.90E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-2.89|P-value:6.14E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.19|P-value:1.89E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.93|P-value:5.74E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.55|P-value:3.58E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.02|P-value:3.72E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.82|P-value:9.81E-6 ID:SGTC_674|Compound:0498-0004|FD-Score:3.66|P-value:2.17E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.84|P-value:1.93E-28 ID:SGTC_763|Compound:3453-1109|FD-Score:3.81|P-value:1.05E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:2.83|P-value:7.81E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.44|P-value:6.22E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:2.86|P-value:7.10E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.75|P-value:1.42E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:2.81|P-value:8.66E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:2.89|P-value:6.39E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.88|P-value:6.66E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:2.94|P-value:5.23E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-4.57|P-value:1.60E-7 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.10|P-value:2.38E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.41|P-value:6.98E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.84|P-value:3.24E-8 ID:SGTC_1531|Compound:st059297|FD-Score:3.21|P-value:1.69E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:2.93|P-value:5.35E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.67|P-value:2.07E-5 ID:SGTC_1634|Compound:st006576|FD-Score:4.49|P-value:2.65E-7 ID:SGTC_1714|Compound:st033236|FD-Score:4.85|P-value:2.98E-8 ID:SGTC_1850|Compound:st056238|FD-Score:-2.85|P-value:7.13E-4 ID:SGTC_2213|Compound:7173844|FD-Score:-2.97|P-value:4.46E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.85|P-value:3.09E-8 ID:SGTC_2335|Compound:9018011|FD-Score:3.49|P-value:5.02E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.76|P-value:5.19E-8 ID:SGTC_2426|Compound:5582046|FD-Score:-3.27|P-value:1.24E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.87|P-value:2.70E-8 ID:SGTC_2445|Compound:5742597|FD-Score:-3.65|P-value:2.23E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.56|P-value:3.51E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:2.98|P-value:4.49E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.17|P-value:1.93E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.18|P-value:1.82E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.54|P-value:2.02E-7 ID:SGTC_2707|Compound:st078556|FD-Score:4.22|P-value:1.26E-6 ID:SGTC_2714|Compound:st079313|FD-Score:-3.36|P-value:8.26E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.77|P-value:9.48E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-2.92|P-value:5.40E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.97|P-value:4.48E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-3.18|P-value:1.88E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-2.88|P-value:6.26E-4 ID:SGTC_3212|Compound:9128307|FD-Score:2.99|P-value:4.30E-4 ID:SGTC_3214|Compound:9129694|FD-Score:2.83|P-value:7.93E-4

Top fitness defect scores for YLR317W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2430 5571206 4.87 200.0 µM 2.70E-8 10 5.58E-7 0.00
2 SGTC_1714 st033236 4.85 13.6 µM 2.98E-8 3 6.04E-7 0.31
3 SGTC_2329 6138490 4.85 200.0 µM 3.09E-8 5 6.21E-7 0.00
4 SGTC_1452 4194-0072 4.84 190.0 µM 3.24E-8 1 6.46E-7 0.74
5 SGTC_133 0724-0033 4.79 378.9 µM 4.50E-8 6 8.42E-7 0.16
6 SGTC_2336 9001819 4.76 198.7 µM 5.19E-8 heme biosynthesis & mitochondrial translocase 28 9.45E-7 0.24
7 SGTC_2703 st077852 4.54 53.4 µM 2.02E-7 3 2.83E-6 0.13
8 SGTC_1634 st006576 4.49 41.0 µM 2.65E-7 TSC3-RPN4 4 3.53E-6 0.51
9 SGTC_135 0933-0004 4.49 26.4 µM 2.74E-7 60S ribosome export 5 3.62E-6 0.56
10 SGTC_84 0443-0269 4.36 128.8 µM 5.51E-7 2 6.37E-6 0.73
11 SGTC_2707 st078556 4.22 66.6 µM 1.26E-6 3 1.25E-5 0.81
12 SGTC_253 dyclonine 4.11 31.2 µM 2.21E-6 amide catabolism 3 1.96E-5 0.08
13 SGTC_1447 4239-0816 4.10 81.9 µM 2.38E-6 9 2.08E-5 0.18
14 SGTC_372 0155-0182 3.93 15.9 µM 5.74E-6 mitochondrial response to ROS 6 4.24E-5 0.23
15 SGTC_602 3130-1533 3.82 38.1 µM 9.81E-6 12 6.55E-5 0.10
16 SGTC_763 3453-1109 3.81 128.0 µM 1.05E-5 5 6.91E-5 0.07
17 SGTC_955 1216-0110 3.75 33.0 µM 1.42E-5 sphingolipid biosynthesis & PDR1 6 8.84E-5 0.30
18 SGTC_1630 st005209 3.67 31.3 µM 2.07E-5 4 1.20E-4 0.61
19 SGTC_674 0498-0004 3.66 451.0 µM 2.17E-5 heme requiring 27 1.25E-4 0.03
20 SGTC_2488 5268135 3.56 45.7 µM 3.51E-5 11 1.84E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.285 6.88E-64 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.247 8.57E-48 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.244 1.78E-46 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.240 2.80E-45 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.234 5.38E-43 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.233 1.88E-42 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.229 4.74E-41 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.213 8.79E-36 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.205 3.49E-33 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.194 8.39E-30 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.193 2.37E-29 YLR440C SEC39 het Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
0.191 7.85E-29 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.178 2.17E-25 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
0.177 3.91E-25 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.169 7.46E-23 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress