YLR325C / RPL38

Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR325C / RPL38

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.90|P-value:4.21E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:3.45|P-value:8.55E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.08|P-value:1.05E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:6.51|P-value:1.67E-9 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.81|P-value:2.71E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.97|P-value:3.12E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.79|P-value:7.16E-8 ID:SGTC_317|Compound:4495-0002|FD-Score:7.29|P-value:1.80E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:3.95|P-value:1.64E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.04|P-value:1.22E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.65|P-value:4.61E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.88|P-value:2.11E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:6.06|P-value:1.82E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.44|P-value:8.83E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.86|P-value:2.25E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.98|P-value:1.49E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.62|P-value:5.13E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.78|P-value:2.94E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.81|P-value:2.72E-4 ID:SGTC_1661|Compound:st013063|FD-Score:-3.89|P-value:2.07E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.01|P-value:1.33E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.48|P-value:8.08E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.90|P-value:2.00E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.56|P-value:6.11E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.90|P-value:2.00E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.07|P-value:1.08E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.51|P-value:7.39E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.85|P-value:2.35E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.02|P-value:1.30E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.41|P-value:9.80E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.90|P-value:4.21E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:3.45|P-value:8.55E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.08|P-value:1.05E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:6.51|P-value:1.67E-9 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.81|P-value:2.71E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.97|P-value:3.12E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.79|P-value:7.16E-8 ID:SGTC_317|Compound:4495-0002|FD-Score:7.29|P-value:1.80E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:3.95|P-value:1.64E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:4.04|P-value:1.22E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.65|P-value:4.61E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.88|P-value:2.11E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:6.06|P-value:1.82E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:3.44|P-value:8.83E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.86|P-value:2.25E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.98|P-value:1.49E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.62|P-value:5.13E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.78|P-value:2.94E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.81|P-value:2.72E-4 ID:SGTC_1661|Compound:st013063|FD-Score:-3.89|P-value:2.07E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.01|P-value:1.33E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.48|P-value:8.08E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.90|P-value:2.00E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.56|P-value:6.11E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.90|P-value:2.00E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.07|P-value:1.08E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.51|P-value:7.39E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.85|P-value:2.35E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.02|P-value:1.30E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.41|P-value:9.80E-4

Top fitness defect scores for YLR325C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_317 4495-0002 7.29 170.0 µM 1.80E-11 2 1.57E-13
2 SGTC_122 0236-0016 6.51 402.4 µM 1.67E-9 RNA processing & uracil transport 6 3.75E-11
3 SGTC_769 0302-0231 6.06 76.0 µM 1.82E-8 7 6.67E-10
4 SGTC_263 alizarin 5.79 107.9 µM 7.16E-8 iron homeostasis 27 3.49E-9
5 SGTC_254 nsc-64875 4.97 3.8 µM 3.12E-6 ergosterol depletion effects on membrane 16 3.29E-7
6 SGTC_6 0844-0013 4.90 19.8 µM 4.21E-6 40 4.73E-7
7 SGTC_119 0121-0043 4.08 24.8 µM 1.05E-4 mitochondrial stress 98 2.25E-5
8 SGTC_2251 lansoprazole 4.07 556.0 µM 1.08E-4 20 2.34E-5
9 SGTC_429 1112-0049 4.04 25.5 µM 1.22E-4 DNA damage response 32 2.70E-5
10 SGTC_2572 astragaloside iv 4.02 100.0 µM 1.30E-4 23 2.92E-5
11 SGTC_1929 genistein trimethyl ether 4.01 50.5 µM 1.33E-4 12 3.00E-5
12 SGTC_1043 0916-0009 3.98 19.3 µM 1.49E-4 22 3.44E-5
13 SGTC_339 3091-4833 3.95 71.4 µM 1.64E-4 iron homeostasis 21 3.85E-5
14 SGTC_2145 5634607 3.90 200.0 µM 2.00E-4 7 4.89E-5
15 SGTC_1953 st076800 3.90 12.1 µM 2.00E-4 51 4.91E-5
16 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.88 150.0 µM 2.11E-4 Golgi 42 5.22E-5
17 SGTC_1038 k292-0204 3.86 154.0 µM 2.25E-4 20 5.65E-5
18 SGTC_2409 alverine citrate 3.85 64.0 µM 2.35E-4 55 5.94E-5
19 SGTC_1466 k213-0079 3.81 57.5 µM 2.72E-4 24 7.07E-5
20 SGTC_1449 4112-4002 3.78 201.0 µM 2.94E-4 RPP1 & pyrimidine depletion 19 7.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.69E-13 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.119 4.45E-12 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.103 1.96E-9 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.097 1.52E-8 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.095 4.17E-8 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.095 4.01E-8 YBR238C YBR238C hom Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
0.094 4.18E-8 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
0.093 6.05E-8 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.093 6.50E-8 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.093 7.79E-8 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.092 8.04E-8 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.090 1.51E-7 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.090 1.73E-7 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.089 2.64E-7 YER131W RPS26B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication
0.088 2.99E-7 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene