HIPHOP chemogenomics database

YLR325C / RPL38

Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR325C / RPL38

Click on Significant Values for Screen Details

Top fitness defect scores for YLR325C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_317	4495-0002	7.29	170.0 µM	1.80E-11		2	1.57E-13
2	SGTC_122	0236-0016	6.51	402.4 µM	1.67E-9	RNA processing & uracil transport	6	3.75E-11
3	SGTC_769	0302-0231	6.06	76.0 µM	1.82E-8		7	6.67E-10
4	SGTC_263	alizarin	5.79	107.9 µM	7.16E-8	iron homeostasis	27	3.49E-9
5	SGTC_254	nsc-64875	4.97	3.8 µM	3.12E-6	ergosterol depletion effects on membrane	16	3.29E-7
6	SGTC_6	0844-0013	4.90	19.8 µM	4.21E-6		40	4.73E-7
7	SGTC_119	0121-0043	4.08	24.8 µM	1.05E-4	mitochondrial stress	98	2.25E-5
8	SGTC_2251	lansoprazole	4.07	556.0 µM	1.08E-4		20	2.34E-5
9	SGTC_429	1112-0049	4.04	25.5 µM	1.22E-4	DNA damage response	32	2.70E-5
10	SGTC_2572	astragaloside iv	4.02	100.0 µM	1.30E-4		23	2.92E-5
11	SGTC_1929	genistein trimethyl ether	4.01	50.5 µM	1.33E-4		12	3.00E-5
12	SGTC_1043	0916-0009	3.98	19.3 µM	1.49E-4		22	3.44E-5
13	SGTC_339	3091-4833	3.95	71.4 µM	1.64E-4	iron homeostasis	21	3.85E-5
14	SGTC_2145	5634607	3.90	200.0 µM	2.00E-4		7	4.89E-5
15	SGTC_1953	st076800	3.90	12.1 µM	2.00E-4		51	4.91E-5
16	SGTC_498	2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)	3.88	150.0 µM	2.11E-4	Golgi	42	5.22E-5
17	SGTC_1038	k292-0204	3.86	154.0 µM	2.25E-4		20	5.65E-5
18	SGTC_2409	alverine citrate	3.85	64.0 µM	2.35E-4		55	5.94E-5
19	SGTC_1466	k213-0079	3.81	57.5 µM	2.72E-4		24	7.07E-5
20	SGTC_1449	4112-4002	3.78	201.0 µM	2.94E-4	RPP1 & pyrimidine depletion	19	7.77E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.126	2.69E-13	YMR115W	MGR3	hom	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.119	4.45E-12	YER009W	NTF2	het	Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.103	1.96E-9	YER162C	RAD4	hom	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.097	1.52E-8	YGR258C	RAD2	hom	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.095	4.17E-8	YMR123W	PKR1	hom	V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.095	4.01E-8	YBR238C	YBR238C	hom	Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
0.094	4.18E-8	YDR085C	AFR1	hom	Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
0.093	6.05E-8	YDL018C	ERP3	hom	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.093	6.50E-8	YBR204C	LDH1	hom	Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.093	7.79E-8	YML095C	RAD10	hom	Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.092	8.04E-8	YPR032W	SRO7	hom	Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.090	1.51E-7	YPL022W	RAD1	hom	Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.090	1.73E-7	YOL061W	PRS5	hom	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.089	2.64E-7	YER131W	RPS26B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication
0.088	2.99E-7	YMR034C_p	YMR034C_p	hom	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene