YLR326W_p

Putative protein of unknown function, predicted to be palmitoylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR326W / YLR326W

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.04|P-value:4.23E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.10|P-value:3.59E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.36|P-value:9.58E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.12|P-value:3.28E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.02|P-value:5.00E-4 ID:SGTC_232|Compound:clozapine|FD-Score:-3.01|P-value:5.20E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.06|P-value:4.28E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.18|P-value:2.61E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.05|P-value:4.82E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:4.61|P-value:2.15E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:2.88|P-value:8.06E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.20|P-value:2.44E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.02|P-value:5.01E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.85|P-value:9.31E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.06|P-value:4.14E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.86|P-value:1.28E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.38|P-value:1.08E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.28|P-value:1.75E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.12|P-value:3.11E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.04|P-value:4.35E-4 ID:SGTC_2258|Compound:7960471|FD-Score:6.58|P-value:2.86E-13 ID:SGTC_2273|Compound:7815444|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.47|P-value:7.15E-5 ID:SGTC_2398|Compound:5228213|FD-Score:5.63|P-value:3.55E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-4.10|P-value:3.74E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.33|P-value:1.39E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.99|P-value:6.09E-6 ID:SGTC_2479|Compound:5617353|FD-Score:2.91|P-value:7.17E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.55|P-value:3.11E-7 ID:SGTC_2780|Compound:5215298|FD-Score:3.22|P-value:2.09E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.37|P-value:9.37E-7 ID:SGTC_2812|Compound:7970281|FD-Score:-2.95|P-value:6.37E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.87|P-value:8.32E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.04|P-value:4.23E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.10|P-value:3.59E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.36|P-value:9.58E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.12|P-value:3.28E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.02|P-value:5.00E-4 ID:SGTC_232|Compound:clozapine|FD-Score:-3.01|P-value:5.20E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.06|P-value:4.28E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.18|P-value:2.61E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.05|P-value:4.82E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:4.61|P-value:2.15E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:2.88|P-value:8.06E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.20|P-value:2.44E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.02|P-value:5.01E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.85|P-value:9.31E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.06|P-value:4.14E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.86|P-value:1.28E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.38|P-value:1.08E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.28|P-value:1.75E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.12|P-value:3.11E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.04|P-value:4.35E-4 ID:SGTC_2258|Compound:7960471|FD-Score:6.58|P-value:2.86E-13 ID:SGTC_2273|Compound:7815444|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.47|P-value:7.15E-5 ID:SGTC_2398|Compound:5228213|FD-Score:5.63|P-value:3.55E-10 ID:SGTC_2400|Compound:5203494|FD-Score:-4.10|P-value:3.74E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.33|P-value:1.39E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.99|P-value:6.09E-6 ID:SGTC_2479|Compound:5617353|FD-Score:2.91|P-value:7.17E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:4.55|P-value:3.11E-7 ID:SGTC_2780|Compound:5215298|FD-Score:3.22|P-value:2.09E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.37|P-value:9.37E-7 ID:SGTC_2812|Compound:7970281|FD-Score:-2.95|P-value:6.37E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_3342|Compound:9147791|FD-Score:2.87|P-value:8.32E-4

Top fitness defect scores for YLR326W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2258 7960471 6.58 200.0 µM 2.86E-13 2 2.33E-11
2 SGTC_2398 5228213 5.63 48.8 µM 3.55E-10 iron homeostasis 11 9.13E-9
3 SGTC_846 0335-0850 4.61 148.0 µM 2.15E-7 ubiquinone biosynthesis & proteasome 23 1.97E-6
4 SGTC_2754 granisetron 4.55 64.0 µM 3.11E-7 22 2.69E-6
5 SGTC_2450 5739737 3.99 12.9 µM 6.09E-6 24 3.28E-5
6 SGTC_2393 9031399 3.47 185.9 µM 7.15E-5 RNA processing & uracil transport 48 2.61E-4
7 SGTC_1630 st005209 3.38 31.3 µM 1.08E-4 47 3.68E-4
8 SGTC_2273 7815444 3.35 169.1 µM 1.18E-4 45 3.97E-4
9 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.31 100.0 µM 1.40E-4 60S ribosome export 48 4.59E-4
10 SGTC_2839 9003951 3.27 26.0 µM 1.68E-4 32 5.36E-4
11 SGTC_2780 5215298 3.22 71.4 µM 2.09E-4 78 6.45E-4
12 SGTC_2179 6298986 3.12 200.0 µM 3.11E-4 heme requiring 44 9.03E-4
13 SGTC_12 0849-0099 3.04 9.3 µM 4.23E-4 49 0.00117
14 SGTC_2253 7938677 3.04 135.8 µM 4.35E-4 41 0.00120
15 SGTC_2479 5617353 2.91 43.9 µM 7.17E-4 85 0.00183
16 SGTC_916 4466-0038 2.88 42.0 nM 8.06E-4 cell wall 162 0.00202
17 SGTC_3342 9147791 2.87 14.5 µM 8.32E-4 61 0.00207
18 SGTC_11 0438-0307 2.82 1.3 µM 0.00101 54 0.00243
19 SGTC_3346 9158254 2.79 43.6 µM 0.00111 84 0.00265
20 SGTC_1988 st071872 2.77 53.4 µM 0.00118 61 0.00278

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.254 1.13E-50 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.229 2.82E-41 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.158 3.14E-20 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.144 6.34E-17 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.142 1.25E-16 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.140 3.64E-16 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.140 3.93E-16 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.139 5.18E-16 YGL261C_p PAU11_p hom Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
0.131 3.00E-14 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.129 5.42E-14 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.126 2.89E-13 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.123 9.09E-13 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.122 1.19E-12 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.122 1.26E-12 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication
0.121 1.85E-12 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)