YLR331C_d / JIP3

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR331C / JIP3

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.74|P-value:7.81E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:5.65|P-value:5.72E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:29.80|P-value:2.47E-199 ID:SGTC_71|Compound:0417-1750|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:6.08|P-value:4.22E-10 ID:SGTC_111|Compound:0083-0039|FD-Score:4.17|P-value:1.25E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.46|P-value:2.34E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:18.70|P-value:1.81E-79 ID:SGTC_173|Compound:1273-0061|FD-Score:3.43|P-value:2.70E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.45|P-value:6.70E-22 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.69|P-value:9.81E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:5.05|P-value:1.71E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:8.60|P-value:1.93E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:4.75|P-value:8.25E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:5.03|P-value:1.89E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:17.50|P-value:2.87E-70 ID:SGTC_360|Compound:0957-0399|FD-Score:13.90|P-value:4.49E-45 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.46|P-value:2.35E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.07|P-value:2.00E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.91|P-value:1.20E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:3.41|P-value:2.88E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:16.10|P-value:1.88E-59 ID:SGTC_663|Compound:1486-0733|FD-Score:10.70|P-value:2.63E-27 ID:SGTC_666|Compound:0272-0154|FD-Score:16.00|P-value:7.98E-59 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.06|P-value:0.00100 ID:SGTC_736|Compound:0958-0254|FD-Score:6.92|P-value:1.37E-12 ID:SGTC_748|Compound:0136-0228|FD-Score:3.24|P-value:5.29E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:12.20|P-value:1.98E-35 ID:SGTC_934|Compound:2950-0684|FD-Score:3.34|P-value:3.77E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.93|P-value:3.63E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.72|P-value:8.67E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.13|P-value:7.90E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.25|P-value:5.21E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.29|P-value:4.53E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.50|P-value:2.03E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.61|P-value:1.35E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.30|P-value:4.22E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.20|P-value:6.10E-4 ID:SGTC_2007|Compound:4011539|FD-Score:13.50|P-value:7.73E-43 ID:SGTC_2009|Compound:4012297|FD-Score:9.96|P-value:4.34E-24 ID:SGTC_2017|Compound:5132927|FD-Score:3.32|P-value:3.98E-4 ID:SGTC_2399|Compound:5884133|FD-Score:8.02|P-value:2.84E-16 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.25|P-value:5.24E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.42|P-value:2.81E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.11|P-value:8.34E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.90|P-value:3.75E-58 ID:SGTC_2584|Compound:androsterone|FD-Score:10.90|P-value:1.09E-28 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.41|P-value:2.86E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-4.36|P-value:5.26E-6 ID:SGTC_2891|Compound:9063876|FD-Score:-3.09|P-value:8.95E-4 ID:SGTC_2912|Compound:7964298|FD-Score:22.40|P-value:7.56E-114 ID:SGTC_2930|Compound:9013230|FD-Score:3.32|P-value:4.06E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.21|P-value:5.86E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.79|P-value:6.41E-5 ID:SGTC_2974|Compound:9094440|FD-Score:5.65|P-value:5.84E-9 ID:SGTC_3137|Compound:9097352|FD-Score:-3.78|P-value:6.78E-5 ID:SGTC_3250|Compound:9135583|FD-Score:3.47|P-value:2.28E-4 ID:SGTC_3266|Compound:9136860|FD-Score:10.40|P-value:4.71E-26 ID:SGTC_3276|Compound:9139060|FD-Score:3.78|P-value:6.66E-5 ID:SGTC_3298|Compound:9116858|FD-Score:3.11|P-value:8.30E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.06|P-value:4.87E-13 ID:SGTC_3321|Compound:9137793|FD-Score:5.21|P-value:7.06E-8 ID:SGTC_3350|Compound:9150499|FD-Score:3.49|P-value:2.13E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.74|P-value:7.81E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:5.65|P-value:5.72E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:29.80|P-value:2.47E-199 ID:SGTC_71|Compound:0417-1750|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:6.08|P-value:4.22E-10 ID:SGTC_111|Compound:0083-0039|FD-Score:4.17|P-value:1.25E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.46|P-value:2.34E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:18.70|P-value:1.81E-79 ID:SGTC_173|Compound:1273-0061|FD-Score:3.43|P-value:2.70E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.45|P-value:6.70E-22 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.69|P-value:9.81E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:5.05|P-value:1.71E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:8.60|P-value:1.93E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:4.75|P-value:8.25E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:5.03|P-value:1.89E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:17.50|P-value:2.87E-70 ID:SGTC_360|Compound:0957-0399|FD-Score:13.90|P-value:4.49E-45 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.46|P-value:2.35E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.07|P-value:2.00E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.91|P-value:1.20E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:3.41|P-value:2.88E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.55|P-value:1.68E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:16.10|P-value:1.88E-59 ID:SGTC_663|Compound:1486-0733|FD-Score:10.70|P-value:2.63E-27 ID:SGTC_666|Compound:0272-0154|FD-Score:16.00|P-value:7.98E-59 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.06|P-value:0.00100 ID:SGTC_736|Compound:0958-0254|FD-Score:6.92|P-value:1.37E-12 ID:SGTC_748|Compound:0136-0228|FD-Score:3.24|P-value:5.29E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:12.20|P-value:1.98E-35 ID:SGTC_934|Compound:2950-0684|FD-Score:3.34|P-value:3.77E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.93|P-value:3.63E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.42|P-value:2.77E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.72|P-value:8.67E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.13|P-value:7.90E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.25|P-value:5.21E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.29|P-value:4.53E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.50|P-value:2.03E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.61|P-value:1.35E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.30|P-value:4.22E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.20|P-value:6.10E-4 ID:SGTC_2007|Compound:4011539|FD-Score:13.50|P-value:7.73E-43 ID:SGTC_2009|Compound:4012297|FD-Score:9.96|P-value:4.34E-24 ID:SGTC_2017|Compound:5132927|FD-Score:3.32|P-value:3.98E-4 ID:SGTC_2399|Compound:5884133|FD-Score:8.02|P-value:2.84E-16 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.25|P-value:5.24E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.42|P-value:2.81E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.11|P-value:8.34E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.90|P-value:3.75E-58 ID:SGTC_2584|Compound:androsterone|FD-Score:10.90|P-value:1.09E-28 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.41|P-value:2.86E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-4.36|P-value:5.26E-6 ID:SGTC_2891|Compound:9063876|FD-Score:-3.09|P-value:8.95E-4 ID:SGTC_2912|Compound:7964298|FD-Score:22.40|P-value:7.56E-114 ID:SGTC_2930|Compound:9013230|FD-Score:3.32|P-value:4.06E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.21|P-value:5.86E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.79|P-value:6.41E-5 ID:SGTC_2974|Compound:9094440|FD-Score:5.65|P-value:5.84E-9 ID:SGTC_3137|Compound:9097352|FD-Score:-3.78|P-value:6.78E-5 ID:SGTC_3250|Compound:9135583|FD-Score:3.47|P-value:2.28E-4 ID:SGTC_3266|Compound:9136860|FD-Score:10.40|P-value:4.71E-26 ID:SGTC_3276|Compound:9139060|FD-Score:3.78|P-value:6.66E-5 ID:SGTC_3298|Compound:9116858|FD-Score:3.11|P-value:8.30E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.06|P-value:4.87E-13 ID:SGTC_3321|Compound:9137793|FD-Score:5.21|P-value:7.06E-8 ID:SGTC_3350|Compound:9150499|FD-Score:3.49|P-value:2.13E-4

Top fitness defect scores for YLR331C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 29.80 9.0 µM 2.47E-199 cell wall 2 1.75E-195
2 SGTC_2912 7964298 22.40 10.9 µM 7.56E-114 cell wall 3 1.15E-111
3 SGTC_138 0850-0259 18.70 40.9 µM 1.81E-79 cell wall 9 5.86E-78
4 SGTC_354 2783-3500 17.50 4.9 µM 2.87E-70 cell wall 3 6.16E-69
5 SGTC_586 0957-0265 16.10 8.2 µM 1.88E-59 cell wall 1 2.49E-58
6 SGTC_666 0272-0154 16.00 136.0 µM 7.98E-59 cell wall 2 1.02E-57
7 SGTC_2582 agaric acid 15.90 100.0 µM 3.75E-58 redox potentiating 7 4.67E-57
8 SGTC_360 0957-0399 13.90 1.0 µM 4.49E-45 cell wall 4 3.12E-44
9 SGTC_2007 4011539 13.50 71.8 µM 7.73E-43 cell wall signaling 7 4.85E-42
10 SGTC_863 0466-0191 12.20 129.0 µM 1.98E-35 cell wall 5 8.92E-35
11 SGTC_2584 androsterone 10.90 48.7 µM 1.09E-28 cell wall 14 3.63E-28
12 SGTC_663 1486-0733 10.70 13.9 µM 2.63E-27 cell wall signaling 12 8.25E-27
13 SGTC_3266 9136860 10.40 49.5 µM 4.71E-26 cell wall 6 1.40E-25
14 SGTC_2009 4012297 9.96 12.1 µM 4.34E-24 cell wall signaling 8 1.18E-23
15 SGTC_255 tunicamycin 9.45 200.5 nM 6.70E-22 unfolded protein response 14 1.65E-21
16 SGTC_304 1310-0298 8.60 97.0 µM 1.93E-18 cell wall 3 4.06E-18
17 SGTC_2399 5884133 8.02 200.0 µM 2.84E-16 cell wall signaling 17 5.44E-16
18 SGTC_3311 9131146 7.06 2.9 µM 4.87E-13 cell wall 46 8.09E-13
19 SGTC_736 0958-0254 6.92 92.6 µM 1.37E-12 Golgi 2 2.23E-12
20 SGTC_91 0417-1751 6.08 58.4 µM 4.22E-10 Golgi 14 6.15E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.724 0 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.697 0 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.587 1.12E-309 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.503 4.82E-215 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.503 4.97E-215 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.491 3.91E-203 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.451 1.44E-167 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.443 1.86E-161 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.438 3.88E-157 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.434 5.69E-154 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.417 1.67E-141 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.413 9.98E-139 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.413 3.32E-138 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.413 3.47E-138 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.412 1.65E-137 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth