YLR335W / NUP2

Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR335W / NUP2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.54|P-value:1.57E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.17|P-value:6.33E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.11|P-value:7.83E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.90|P-value:2.70E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:3.55|P-value:1.47E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.42|P-value:2.49E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.37|P-value:3.01E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.09|P-value:8.48E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.06|P-value:9.42E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:6.07|P-value:2.51E-10 ID:SGTC_710|Compound:3448-4187|FD-Score:4.04|P-value:1.86E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.26|P-value:4.55E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.70|P-value:5.11E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.24|P-value:4.93E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.07|P-value:8.90E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.91|P-value:3.37E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.39|P-value:3.62E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.42|P-value:1.68E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.21|P-value:3.65E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.26|P-value:6.72E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.39|P-value:1.86E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.73|P-value:7.24E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.06|P-value:9.24E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.19|P-value:5.82E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.49|P-value:1.92E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.41|P-value:2.58E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:8.86|P-value:4.22E-20 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.24|P-value:4.99E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-5.49|P-value:4.85E-9 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.14|P-value:7.09E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.81|P-value:3.22E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.78|P-value:5.84E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-4.14|P-value:7.31E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-5.10|P-value:4.99E-8 ID:SGTC_1952|Compound:st077036|FD-Score:-3.79|P-value:3.53E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.93|P-value:3.10E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.10|P-value:8.24E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.38|P-value:2.85E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.50|P-value:1.84E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-5.50|P-value:4.61E-9 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.47|P-value:2.03E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.38|P-value:1.95E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.10|P-value:8.01E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.89|P-value:3.55E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-5.47|P-value:5.70E-9 ID:SGTC_2928|Compound:9011484|FD-Score:4.10|P-value:1.43E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.71|P-value:7.80E-5 ID:SGTC_3040|Compound:9091894|FD-Score:3.75|P-value:6.54E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.54|P-value:1.57E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.17|P-value:6.33E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.11|P-value:7.83E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.90|P-value:2.70E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:3.55|P-value:1.47E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.42|P-value:2.49E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.37|P-value:3.01E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.09|P-value:8.48E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.06|P-value:9.42E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:6.07|P-value:2.51E-10 ID:SGTC_710|Compound:3448-4187|FD-Score:4.04|P-value:1.86E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.26|P-value:4.55E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.70|P-value:5.11E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.24|P-value:4.93E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.07|P-value:8.90E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.91|P-value:3.37E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.39|P-value:3.62E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.42|P-value:1.68E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.21|P-value:3.65E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.26|P-value:6.72E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.39|P-value:1.86E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.73|P-value:7.24E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.06|P-value:9.24E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.19|P-value:5.82E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.49|P-value:1.92E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.41|P-value:2.58E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:8.86|P-value:4.22E-20 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.46|P-value:1.39E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.24|P-value:4.99E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-5.49|P-value:4.85E-9 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.14|P-value:7.09E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-3.81|P-value:3.22E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.78|P-value:5.84E-5 ID:SGTC_1902|Compound:st060212|FD-Score:-4.14|P-value:7.31E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-5.10|P-value:4.99E-8 ID:SGTC_1952|Compound:st077036|FD-Score:-3.79|P-value:3.53E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.93|P-value:3.10E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.10|P-value:8.24E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.38|P-value:2.85E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.50|P-value:1.84E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-5.50|P-value:4.61E-9 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.47|P-value:2.03E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.38|P-value:1.95E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.10|P-value:8.01E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.89|P-value:3.55E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-5.47|P-value:5.70E-9 ID:SGTC_2928|Compound:9011484|FD-Score:4.10|P-value:1.43E-5 ID:SGTC_2972|Compound:9093619|FD-Score:3.71|P-value:7.80E-5 ID:SGTC_3040|Compound:9091894|FD-Score:3.75|P-value:6.54E-5

Top fitness defect scores for YLR335W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1564 D-Arginine 8.86 115.0 µM 4.22E-20 1 4.02E-19
2 SGTC_524 r073-0010 6.07 27.8 µM 2.51E-10 15 6.55E-10
3 SGTC_145 3737-0113 4.90 38.4 µM 2.70E-7 DNA intercalators 47 4.81E-7
4 SGTC_960 1222-0186 4.39 7.7 µM 3.62E-6 21 5.63E-6
5 SGTC_1107 amlodipine 4.26 47.0 µM 6.72E-6 24 1.01E-5
6 SGTC_2928 9011484 4.10 9.8 µM 1.43E-5 heme biosynthesis & mitochondrial translocase 35 2.08E-5
7 SGTC_710 3448-4187 4.04 58.0 µM 1.86E-5 fatty acid desaturase (OLE1) 58 2.66E-5
8 SGTC_2097 5376186 3.93 200.0 µM 3.10E-5 21 4.32E-5
9 SGTC_942 3253-1115 3.91 227.0 µM 3.37E-5 29 4.68E-5
10 SGTC_2921 7974240 3.89 10.7 µM 3.55E-5 59 4.92E-5
11 SGTC_1901 st060216 3.78 58.6 µM 5.84E-5 25 7.89E-5
12 SGTC_3040 9091894 3.75 49.5 µM 6.54E-5 DNA intercalators 21 8.79E-5
13 SGTC_1468 k284-1086 3.73 134.0 µM 7.24E-5 DNA intercalators 46 9.69E-5
14 SGTC_2972 9093619 3.71 59.9 µM 7.80E-5 24 1.04E-4
15 SGTC_203 k066-0004 3.55 30.9 µM 1.47E-4 RSC & ERG11 31 1.90E-4
16 SGTC_58 0957-0393 3.54 9.0 µM 1.57E-4 cell wall 426 2.02E-4
17 SGTC_2296 7971656 3.50 126.5 µM 1.84E-4 60 2.35E-4
18 SGTC_1493 4348-0038 3.49 111.0 µM 1.92E-4 RSC complex & mRNA processing 46 2.44E-4
19 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.47 92.6 µM 2.03E-4 40 2.58E-4
20 SGTC_229 benomyl 3.42 22.9 µM 2.49E-4 tubulin folding & SWR complex 43 3.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 1.87E-42 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.233 2.11E-42 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.215 2.15E-36 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.212 2.16E-35 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.189 2.12E-28 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.166 3.19E-22 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.158 4.26E-20 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.157 7.93E-20 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.156 9.57E-20 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.156 1.17E-19 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.149 3.28E-18 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.137 1.90E-15 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 2.04E-15 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.134 6.11E-15 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.128 9.87E-14 YDL102W POL3 het Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)