YLR345W_p

Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR345W / YLR345W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.88|P-value:5.69E-9 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.89|P-value:9.84E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.37|P-value:5.15E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.61|P-value:3.69E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.30|P-value:1.44E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:4.12|P-value:3.13E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.61|P-value:2.24E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.47|P-value:9.26E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.64|P-value:3.29E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.31|P-value:6.24E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.46|P-value:3.74E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.08|P-value:4.55E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.70|P-value:1.59E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.90|P-value:7.51E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.28|P-value:8.58E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.73|P-value:1.44E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.89|P-value:7.69E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.30|P-value:6.46E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.80|P-value:1.10E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.25|P-value:9.32E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.69|P-value:1.62E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.41|P-value:4.49E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.31|P-value:6.37E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.44|P-value:4.97E-4 ID:SGTC_2892|Compound:9047358|FD-Score:4.62|P-value:3.59E-6 ID:SGTC_2897|Compound:9048598|FD-Score:3.88|P-value:8.11E-5 ID:SGTC_2980|Compound:9014342|FD-Score:11.40|P-value:1.40E-28 ID:SGTC_2981|Compound:9013952|FD-Score:-4.36|P-value:1.43E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.44|P-value:4.10E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.35|P-value:5.50E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.28|P-value:6.94E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.91|P-value:8.89E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.38|P-value:4.94E-4 ID:SGTC_3228|Compound:9131799|FD-Score:-3.28|P-value:8.41E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.88|P-value:5.69E-9 ID:SGTC_11|Compound:0438-0307|FD-Score:-3.89|P-value:9.84E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.37|P-value:5.15E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.61|P-value:3.69E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.30|P-value:1.44E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:3.56|P-value:2.70E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:4.12|P-value:3.13E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.61|P-value:2.24E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.47|P-value:9.26E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.64|P-value:3.29E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.31|P-value:6.24E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.46|P-value:3.74E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-4.08|P-value:4.55E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.70|P-value:1.59E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.90|P-value:7.51E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.28|P-value:8.58E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.73|P-value:1.44E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.89|P-value:7.69E-5 ID:SGTC_1937|Compound:st074714|FD-Score:3.30|P-value:6.46E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.80|P-value:1.10E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.25|P-value:9.32E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.69|P-value:1.62E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.41|P-value:4.49E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.31|P-value:6.37E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.44|P-value:4.97E-4 ID:SGTC_2892|Compound:9047358|FD-Score:4.62|P-value:3.59E-6 ID:SGTC_2897|Compound:9048598|FD-Score:3.88|P-value:8.11E-5 ID:SGTC_2980|Compound:9014342|FD-Score:11.40|P-value:1.40E-28 ID:SGTC_2981|Compound:9013952|FD-Score:-4.36|P-value:1.43E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.44|P-value:4.10E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.35|P-value:5.50E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.28|P-value:6.94E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-3.91|P-value:8.89E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.38|P-value:4.94E-4 ID:SGTC_3228|Compound:9131799|FD-Score:-3.28|P-value:8.41E-4

Top fitness defect scores for YLR345W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2980 9014342 11.40 25.3 µM 1.40E-28 4 2.23E-30
2 SGTC_6 0844-0013 5.88 19.8 µM 5.69E-9 17 2.00E-9
3 SGTC_437 s-farnesyl-l-cysteine methyl ester 4.64 6.7 µM 3.29E-6 6 1.75E-6
4 SGTC_2892 9047358 4.62 58.4 µM 3.59E-6 4 1.92E-6
5 SGTC_158 k038-0087 4.61 26.4 µM 3.69E-6 ubiquinone biosynthesis & proteasome 106 1.98E-6
6 SGTC_260 nsc-65238 4.30 4.0 µM 1.44E-5 endomembrane recycling 10 8.39E-6
7 SGTC_298 1391-0729 4.12 10.0 µM 3.13E-5 calcium & mitochondrial duress 16 1.92E-5
8 SGTC_1197 1601-0112 3.90 267.0 µM 7.51E-5 20 4.86E-5
9 SGTC_1849 st056239 3.89 19.2 µM 7.69E-5 RPP1 & pyrimidine depletion 27 4.98E-5
10 SGTC_2897 9048598 3.88 13.0 µM 8.11E-5 17 5.27E-5
11 SGTC_1953 st076800 3.80 12.1 µM 1.10E-4 54 7.33E-5
12 SGTC_1638 st008370 3.77 60.6 µM 1.22E-4 ergosterol biosynthesis 34 8.14E-5
13 SGTC_1696 st025591 3.73 34.8 µM 1.44E-4 SWF1 & branched chain AA biosynthesis 35 9.70E-5
14 SGTC_1125 tnp00248 3.70 1.3 µM 1.59E-4 37 1.08E-4
15 SGTC_2020 4017018 3.69 200.0 µM 1.62E-4 28 1.10E-4
16 SGTC_410 α-linolenic acid 3.61 100.0 µM 2.24E-4 excess fatty acid 48 1.55E-4
17 SGTC_294 k038-0071 3.56 157.0 µM 2.70E-4 ubiquinone biosynthesis & proteasome 75 1.89E-4
18 SGTC_751 0833-0568 3.46 350.0 µM 3.74E-4 37 2.67E-4
19 SGTC_3002 9075603 3.44 71.4 µM 4.10E-4 39 2.94E-4
20 SGTC_2314 7727897 3.41 200.0 µM 4.49E-4 40 3.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.47E-14 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.127 1.48E-13 YGR046W TAM41 het Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
0.120 3.67E-12 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.115 2.34E-11 YLR366W_d YLR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
0.115 2.56E-11 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.114 3.92E-11 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.108 3.20E-10 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.108 3.76E-10 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.106 8.52E-10 YCR006C_d YCR006C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.42E-9 YKR101W SIR1 hom Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
0.101 3.97E-9 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.100 6.26E-9 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.099 9.45E-9 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.098 1.29E-8 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.098 1.48E-8 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions