YLR346C_p

Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR346C / YLR346C

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:6.28|P-value:1.35E-12 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.22|P-value:1.94E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:2.98|P-value:4.31E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:2.93|P-value:5.24E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.00|P-value:4.76E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-2.81|P-value:9.83E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.69|P-value:2.43E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.07|P-value:3.69E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.42|P-value:8.33E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.48|P-value:6.41E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.33|P-value:1.24E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.92|P-value:6.48E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.07|P-value:3.64E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.41|P-value:8.49E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.04|P-value:4.26E-6 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.14|P-value:2.69E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.02|P-value:4.70E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:6.39|P-value:5.30E-13 ID:SGTC_917|Compound:harmaline|FD-Score:3.41|P-value:6.90E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.66|P-value:9.74E-8 ID:SGTC_933|Compound:2914-0560|FD-Score:2.85|P-value:7.21E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.90|P-value:5.91E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.42|P-value:6.28E-13 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.00|P-value:3.94E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:2.83|P-value:7.54E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.24|P-value:1.45E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.85|P-value:6.97E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.36|P-value:8.61E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-4.17|P-value:2.13E-6 ID:SGTC_1678|Compound:st019265|FD-Score:4.01|P-value:3.78E-6 ID:SGTC_1744|Compound:st037937|FD-Score:2.93|P-value:5.17E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.01|P-value:3.85E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.93|P-value:5.29E-4 ID:SGTC_2038|Compound:4100038|FD-Score:2.87|P-value:6.49E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.85|P-value:6.99E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.92|P-value:6.11E-6 ID:SGTC_2601|Compound:securinine|FD-Score:-2.90|P-value:7.04E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-4.56|P-value:2.37E-7 ID:SGTC_2826|Compound:7992541|FD-Score:-3.74|P-value:1.87E-5 ID:SGTC_2928|Compound:9011484|FD-Score:2.77|P-value:9.50E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.89|P-value:6.11E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-2.89|P-value:7.42E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.24|P-value:1.84E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:6.28|P-value:1.35E-12 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.22|P-value:1.94E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:2.98|P-value:4.31E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:2.93|P-value:5.24E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.00|P-value:4.76E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-2.81|P-value:9.83E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.69|P-value:2.43E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.07|P-value:3.69E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.42|P-value:8.33E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.48|P-value:6.41E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.33|P-value:1.24E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.92|P-value:6.48E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.07|P-value:3.64E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.41|P-value:8.49E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.04|P-value:4.26E-6 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.14|P-value:2.69E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.02|P-value:4.70E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:6.39|P-value:5.30E-13 ID:SGTC_917|Compound:harmaline|FD-Score:3.41|P-value:6.90E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.66|P-value:9.74E-8 ID:SGTC_933|Compound:2914-0560|FD-Score:2.85|P-value:7.21E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.90|P-value:5.91E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.42|P-value:6.28E-13 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.00|P-value:3.94E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:2.83|P-value:7.54E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.24|P-value:1.45E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.85|P-value:6.97E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.36|P-value:8.61E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-4.17|P-value:2.13E-6 ID:SGTC_1678|Compound:st019265|FD-Score:4.01|P-value:3.78E-6 ID:SGTC_1744|Compound:st037937|FD-Score:2.93|P-value:5.17E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.01|P-value:3.85E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.93|P-value:5.29E-4 ID:SGTC_2038|Compound:4100038|FD-Score:2.87|P-value:6.49E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.85|P-value:6.99E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.92|P-value:6.11E-6 ID:SGTC_2601|Compound:securinine|FD-Score:-2.90|P-value:7.04E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-4.56|P-value:2.37E-7 ID:SGTC_2826|Compound:7992541|FD-Score:-3.74|P-value:1.87E-5 ID:SGTC_2928|Compound:9011484|FD-Score:2.77|P-value:9.50E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.89|P-value:6.11E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-2.89|P-value:7.42E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.24|P-value:1.84E-4

Top fitness defect scores for YLR346C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_916 4466-0038 6.39 42.0 nM 5.30E-13 cell wall 24 8.13E-11
2 SGTC_73 0327-0325 6.28 16.2 µM 1.35E-12 DNA damage response 14 1.74E-10
3 SGTC_918 glabranin 4.66 770.7 nM 9.74E-8 17 1.55E-6
4 SGTC_1678 st019265 4.01 80.2 µM 3.78E-6 60S ribosome export 17 3.05E-5
5 SGTC_2576 guaiol 3.92 23.1 µM 6.11E-6 21 4.50E-5
6 SGTC_917 harmaline 3.41 728.1 nM 6.90E-5 ergosterol biosynthesis 47 3.25E-4
7 SGTC_1565 sinapyl alcohol 3.36 95.1 µM 8.61E-5 56 3.90E-4
8 SGTC_1235 benzylparaben 3.24 21.5 µM 1.45E-4 29 5.96E-4
9 SGTC_1811 st050069 3.01 61.5 µM 3.85E-4 19 0.00133
10 SGTC_1176 0848-0131 3.00 83.3 µM 3.94E-4 Golgi 59 0.00135
11 SGTC_110 0850-0284 2.98 111.6 µM 4.31E-4 32 0.00146
12 SGTC_1744 st037937 2.93 38.9 µM 5.17E-4 76 0.00169
13 SGTC_185 k048-0037 2.93 25.5 µM 5.24E-4 RSC & ERG11 40 0.00171
14 SGTC_1913 st060213 2.93 96.1 µM 5.29E-4 95 0.00172
15 SGTC_938 3126-1755 2.90 342.0 µM 5.91E-4 49 0.00188
16 SGTC_3086 9117350 2.89 49.5 µM 6.11E-4 17 0.00194
17 SGTC_2038 4100038 2.87 31.0 µM 6.49E-4 plasma membrane duress 102 0.00203
18 SGTC_1261 0712-0010 2.85 12.7 µM 6.97E-4 RNA processing & uracil transport 84 0.00215
19 SGTC_2130 NSC 7 2.85 2.5 µM 6.99E-4 copper-dependent oxidative stress 101 0.00216
20 SGTC_933 2914-0560 2.85 114.0 µM 7.21E-4 83 0.00222

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 1.97E-40 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.206 2.13E-33 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.202 3.28E-32 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.199 2.16E-31 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.199 2.60E-31 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.196 2.00E-30 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.195 5.31E-30 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.193 2.35E-29 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.185 4.26E-27 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.184 7.82E-27 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.182 2.02E-26 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.177 3.89E-25 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.173 6.16E-24 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.172 8.79E-24 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.172 1.14E-23 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization