YLR349W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR349W / YLR349W

Click on Significant Values for Screen Details ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.17|P-value:4.30E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:5.84|P-value:3.81E-10 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.25|P-value:2.95E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.52|P-value:9.09E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.38|P-value:1.87E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.05|P-value:6.17E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.94|P-value:9.83E-8 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.89|P-value:2.13E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-4.46|P-value:1.25E-6 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.41|P-value:1.69E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.01|P-value:7.29E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.95|P-value:9.09E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.63|P-value:5.42E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.46|P-value:1.29E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.93|P-value:9.59E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.01|P-value:7.34E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-8.05|P-value:9.87E-18 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.41|P-value:1.53E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:6.20|P-value:3.19E-11 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.09|P-value:5.74E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.49|P-value:1.12E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.38|P-value:2.02E-6 ID:SGTC_2926|Compound:9010726|FD-Score:-4.10|P-value:7.35E-6 ID:SGTC_2968|Compound:9090663|FD-Score:3.37|P-value:1.95E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.21|P-value:3.38E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.12|P-value:5.14E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.23|P-value:3.34E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.07|P-value:6.18E-4 ID:SGTC_3298|Compound:9116858|FD-Score:2.98|P-value:8.60E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.17|P-value:4.30E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:5.84|P-value:3.81E-10 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.25|P-value:2.95E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.52|P-value:9.09E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.38|P-value:1.87E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.05|P-value:6.17E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.94|P-value:9.83E-8 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.89|P-value:2.13E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-4.46|P-value:1.25E-6 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.41|P-value:1.69E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.01|P-value:7.29E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.95|P-value:9.09E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.19|P-value:3.91E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.63|P-value:5.42E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.46|P-value:1.29E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.93|P-value:9.59E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.01|P-value:7.34E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-8.05|P-value:9.87E-18 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.41|P-value:1.53E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:6.20|P-value:3.19E-11 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.09|P-value:5.74E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.49|P-value:1.12E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.38|P-value:2.02E-6 ID:SGTC_2926|Compound:9010726|FD-Score:-4.10|P-value:7.35E-6 ID:SGTC_2968|Compound:9090663|FD-Score:3.37|P-value:1.95E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.21|P-value:3.38E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.12|P-value:5.14E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.23|P-value:3.34E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.07|P-value:6.18E-4 ID:SGTC_3298|Compound:9116858|FD-Score:2.98|P-value:8.60E-4

Top fitness defect scores for YLR349W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2611 pyromycin 6.20 23.9 µM 3.19E-11 4 2.75E-10
2 SGTC_359 0081-0058 5.84 15.9 µM 3.81E-10 60S ribosome export 10 2.58E-9
3 SGTC_1370 2001-0092 4.94 44.6 µM 9.83E-8 13 3.88E-7
4 SGTC_2050 5263056 4.63 171.0 µM 5.42E-7 fatty acid desaturase (OLE1) 31 1.81E-6
5 SGTC_2925 9010536 4.38 32.5 µM 2.02E-6 azole & statin 34 5.97E-6
6 SGTC_1379 2144-0755 3.89 36.5 µM 2.13E-5 26 5.04E-5
7 SGTC_1587 estradiol valerate 3.41 56.1 µM 1.69E-4 24 3.28E-4
8 SGTC_762 1165-0429 3.38 115.0 µM 1.87E-4 TSC3-RPN4 37 3.61E-4
9 SGTC_2968 9090663 3.37 33.4 µM 1.95E-4 52 3.73E-4
10 SGTC_2975 9084847 3.23 53.7 µM 3.34E-4 59 6.10E-4
11 SGTC_1756 st041558 3.19 35.5 µM 3.91E-4 26 7.03E-4
12 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.17 44.4 nM 4.30E-4 DNA damage response 53 7.66E-4
13 SGTC_2974 9094440 3.12 9.7 µM 5.14E-4 ergosterol biosynthesis 86 9.01E-4
14 SGTC_2621 lithochol-11-enic acid 3.09 100.0 µM 5.74E-4 73 9.96E-4
15 SGTC_3055 9094636 3.07 49.5 µM 6.18E-4 40 0.00106
16 SGTC_3298 9116858 2.98 71.4 µM 8.60E-4 46 0.00144
17 SGTC_3290 9121031 2.91 71.4 µM 0.00112 50 0.00183
18 SGTC_2606 farnesol 2.90 9.8 µM 0.00114 79 0.00186
19 SGTC_533 1222-0222 2.88 6.7 µM 0.00121 PDR1 78 0.00196
20 SGTC_2961 9083290 2.86 32.5 µM 0.00130 61 0.00210

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.08E-15 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.132 1.51E-14 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.129 6.67E-14 YGL160W AIM14 hom NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p
0.128 9.37E-14 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.127 1.28E-13 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.127 1.50E-13 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
0.118 5.87E-12 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.118 6.60E-12 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.112 8.79E-11 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.112 9.27E-11 YKR083C DAD2 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.110 1.49E-10 YHR139C-A_d YHR139C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.65E-10 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.108 3.45E-10 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.106 6.65E-10 YBL040C ERD2 het HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
0.104 1.31E-9 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p