YLR350W / ORM2

Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR350W / ORM2

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.46|P-value:9.89E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.43|P-value:4.46E-10 ID:SGTC_114|Compound:0364-0001|FD-Score:3.41|P-value:5.43E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.94|P-value:8.27E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.45|P-value:4.84E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.75|P-value:1.67E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:10.40|P-value:1.15E-23 ID:SGTC_208|Compound:k072-0098|FD-Score:5.57|P-value:4.87E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.63|P-value:2.69E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.69|P-value:3.70E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:3.47|P-value:4.47E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:8.21|P-value:2.04E-15 ID:SGTC_305|Compound:1682-2595|FD-Score:-4.00|P-value:6.81E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:6.06|P-value:3.44E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.72|P-value:1.86E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:7.93|P-value:1.70E-14 ID:SGTC_320|Compound:4092-0846|FD-Score:5.83|P-value:1.26E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:6.61|P-value:1.29E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:5.28|P-value:2.16E-7 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.82|P-value:1.38E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.38|P-value:6.43E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.31|P-value:7.64E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.65|P-value:2.38E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:9.26|P-value:4.38E-19 ID:SGTC_668|Compound:1682-0499|FD-Score:3.36|P-value:6.59E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.49|P-value:4.12E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.50|P-value:7.14E-8 ID:SGTC_785|Compound:1270-0111|FD-Score:3.58|P-value:3.06E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.46|P-value:4.68E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:6.01|P-value:4.64E-9 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.63|P-value:2.60E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.59|P-value:2.94E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.31|P-value:1.84E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.12|P-value:4.04E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.39|P-value:1.43E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.12|P-value:4.09E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.83|P-value:1.24E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.99|P-value:6.73E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-3.32|P-value:7.79E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.63|P-value:2.56E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.34|P-value:7.04E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.89|P-value:9.41E-18 ID:SGTC_1818|Compound:st052136|FD-Score:3.44|P-value:4.91E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.26|P-value:9.42E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.69|P-value:2.07E-4 ID:SGTC_2050|Compound:5263056|FD-Score:6.09|P-value:2.94E-9 ID:SGTC_2086|Compound:5274770|FD-Score:-3.77|P-value:1.67E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.30|P-value:8.22E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.24|P-value:2.66E-7 ID:SGTC_2231|Compound:micatex|FD-Score:4.12|P-value:3.99E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.73|P-value:7.17E-14 ID:SGTC_2306|Compound:7482397|FD-Score:4.15|P-value:3.57E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.38|P-value:6.05E-4 ID:SGTC_2339|Compound:9000433|FD-Score:6.62|P-value:1.20E-10 ID:SGTC_2369|Compound:9071472|FD-Score:3.36|P-value:6.44E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.90|P-value:9.44E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.91|P-value:7.97E-9 ID:SGTC_2449|Compound:5812982|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.05|P-value:5.39E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.60|P-value:1.44E-24 ID:SGTC_2686|Compound:alizarin|FD-Score:3.40|P-value:5.67E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.34|P-value:7.21E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.64|P-value:4.59E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.77|P-value:2.57E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:6.44|P-value:3.79E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:11.20|P-value:3.13E-27 ID:SGTC_2906|Compound:7926292|FD-Score:-3.34|P-value:7.41E-4 ID:SGTC_2948|Compound:9070189|FD-Score:6.56|P-value:1.75E-10 ID:SGTC_2978|Compound:9011784|FD-Score:5.28|P-value:2.20E-7 ID:SGTC_3140|Compound:9094243|FD-Score:3.54|P-value:3.47E-4 ID:SGTC_3152|Compound:9099253|FD-Score:9.98|P-value:7.40E-22 ID:SGTC_3293|Compound:9120939|FD-Score:3.95|P-value:7.74E-5 ID:SGTC_3308|Compound:9128332|FD-Score:8.44|P-value:3.54E-16 ID:SGTC_16|Compound:erodoxin|FD-Score:4.46|P-value:9.89E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.43|P-value:4.46E-10 ID:SGTC_114|Compound:0364-0001|FD-Score:3.41|P-value:5.43E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.94|P-value:8.27E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.45|P-value:4.84E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.75|P-value:1.67E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:10.40|P-value:1.15E-23 ID:SGTC_208|Compound:k072-0098|FD-Score:5.57|P-value:4.87E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.63|P-value:2.69E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.69|P-value:3.70E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:3.47|P-value:4.47E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:8.21|P-value:2.04E-15 ID:SGTC_305|Compound:1682-2595|FD-Score:-4.00|P-value:6.81E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:6.06|P-value:3.44E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:3.72|P-value:1.86E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:7.93|P-value:1.70E-14 ID:SGTC_320|Compound:4092-0846|FD-Score:5.83|P-value:1.26E-8 ID:SGTC_352|Compound:k048-0007|FD-Score:6.61|P-value:1.29E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:5.28|P-value:2.16E-7 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.82|P-value:1.38E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.38|P-value:6.43E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.31|P-value:7.64E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.65|P-value:2.38E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:9.26|P-value:4.38E-19 ID:SGTC_668|Compound:1682-0499|FD-Score:3.36|P-value:6.59E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.49|P-value:4.12E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:5.50|P-value:7.14E-8 ID:SGTC_785|Compound:1270-0111|FD-Score:3.58|P-value:3.06E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.46|P-value:4.68E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:6.01|P-value:4.64E-9 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.63|P-value:2.60E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.59|P-value:2.94E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.31|P-value:1.84E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.12|P-value:4.04E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.39|P-value:1.43E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.12|P-value:4.09E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.83|P-value:1.24E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.99|P-value:6.73E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-3.32|P-value:7.79E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.63|P-value:2.56E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.34|P-value:7.04E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.89|P-value:9.41E-18 ID:SGTC_1818|Compound:st052136|FD-Score:3.44|P-value:4.91E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.26|P-value:9.42E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.69|P-value:2.07E-4 ID:SGTC_2050|Compound:5263056|FD-Score:6.09|P-value:2.94E-9 ID:SGTC_2086|Compound:5274770|FD-Score:-3.77|P-value:1.67E-4 ID:SGTC_2108|Compound:5365811|FD-Score:-3.30|P-value:8.22E-4 ID:SGTC_2124|Compound:5246320|FD-Score:5.24|P-value:2.66E-7 ID:SGTC_2231|Compound:micatex|FD-Score:4.12|P-value:3.99E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.73|P-value:7.17E-14 ID:SGTC_2306|Compound:7482397|FD-Score:4.15|P-value:3.57E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.38|P-value:6.05E-4 ID:SGTC_2339|Compound:9000433|FD-Score:6.62|P-value:1.20E-10 ID:SGTC_2369|Compound:9071472|FD-Score:3.36|P-value:6.44E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.90|P-value:9.44E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.91|P-value:7.97E-9 ID:SGTC_2449|Compound:5812982|FD-Score:3.58|P-value:3.03E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.05|P-value:5.39E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.60|P-value:1.44E-24 ID:SGTC_2686|Compound:alizarin|FD-Score:3.40|P-value:5.67E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.34|P-value:7.21E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.64|P-value:4.59E-6 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.77|P-value:2.57E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:6.44|P-value:3.79E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:11.20|P-value:3.13E-27 ID:SGTC_2906|Compound:7926292|FD-Score:-3.34|P-value:7.41E-4 ID:SGTC_2948|Compound:9070189|FD-Score:6.56|P-value:1.75E-10 ID:SGTC_2978|Compound:9011784|FD-Score:5.28|P-value:2.20E-7 ID:SGTC_3140|Compound:9094243|FD-Score:3.54|P-value:3.47E-4 ID:SGTC_3152|Compound:9099253|FD-Score:9.98|P-value:7.40E-22 ID:SGTC_3293|Compound:9120939|FD-Score:3.95|P-value:7.74E-5 ID:SGTC_3308|Compound:9128332|FD-Score:8.44|P-value:3.54E-16

Top fitness defect scores for YLR350W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2778 tioconazole 11.20 65.1 nM 3.13E-27 ergosterol depletion effects on membrane 12 1.25E-29
2 SGTC_2582 agaric acid 10.60 100.0 µM 1.44E-24 redox potentiating 56 1.03E-26
3 SGTC_201 4262-0159 10.40 12.8 µM 1.15E-23 ergosterol depletion effects on membrane 6 1.00E-25
4 SGTC_3152 9099253 9.98 49.5 µM 7.40E-22 NEO1-PIK1 23 9.53E-24
5 SGTC_637 1181-0519 9.26 7.3 µM 4.38E-19 fatty acid desaturase (OLE1) 24 1.03E-20
6 SGTC_1750 st081859 8.89 2.4 µM 9.41E-18 endomembrane recycling 53 2.96E-19
7 SGTC_3308 9128332 8.44 17.6 µM 3.54E-16 plasma membrane duress 28 1.57E-17
8 SGTC_299 1273-0059 8.21 1.4 µM 2.04E-15 2 1.06E-16
9 SGTC_312 4092-0653 7.93 6.8 µM 1.70E-14 ergosterol depletion effects on membrane 21 1.08E-15
10 SGTC_2249 haloperidol 7.73 116.4 µM 7.17E-14 ergosterol depletion effects on membrane 26 5.23E-15
11 SGTC_2339 9000433 6.62 200.0 µM 1.20E-10 4 1.76E-11
12 SGTC_352 k048-0007 6.61 5.1 µM 1.29E-10 ERAD & cell cycle 26 1.89E-11
13 SGTC_2948 9070189 6.56 9.4 µM 1.75E-10 plasma membrane duress 21 2.65E-11
14 SGTC_2777 climbazole 6.44 1.5 µM 3.79E-10 iron homeostasis 8 6.17E-11
15 SGTC_2050 5263056 6.09 171.0 µM 2.94E-9 fatty acid desaturase (OLE1) 10 5.78E-10
16 SGTC_308 4092-1169 6.06 104.0 µM 3.44E-9 plasma membrane duress 18 6.85E-10
17 SGTC_875 0709-0210 6.01 25.7 µM 4.64E-9 fatty acid desaturase (OLE1) 10 9.51E-10
18 SGTC_2409 alverine citrate 5.91 64.0 µM 7.97E-9 21 1.72E-9
19 SGTC_320 4092-0846 5.83 5.3 µM 1.26E-8 ergosterol depletion effects on membrane 16 2.83E-9
20 SGTC_208 k072-0098 5.57 12.4 µM 4.87E-8 heme biosynthesis & mitochondrial translocase 17 1.24E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.425 6.00E-147 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.338 2.89E-90 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.314 1.41E-77 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.301 1.93E-71 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.291 2.92E-66 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.277 4.93E-60 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.276 7.13E-60 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.268 2.71E-56 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.266 1.60E-55 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.256 3.16E-51 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.255 5.62E-51 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.254 1.51E-50 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.242 4.91E-46 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.242 6.26E-46 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.239 1.10E-44 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data