YLR351C / NIT3

Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR351C / NIT3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.57|P-value:5.04E-5 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.88|P-value:1.14E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:5.13|P-value:1.12E-8 ID:SGTC_337|Compound:1315-0038|FD-Score:3.62|P-value:3.99E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.19|P-value:2.52E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.12|P-value:3.38E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.37|P-value:1.23E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.01|P-value:5.21E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.53|P-value:5.95E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.07|P-value:4.66E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.61|P-value:2.52E-7 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:2.87|P-value:9.08E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.23|P-value:2.23E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.33|P-value:1.43E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.90|P-value:7.92E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.45|P-value:8.75E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.09|P-value:3.78E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.81|P-value:1.65E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.66|P-value:3.34E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-4.51|P-value:4.34E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.87|P-value:1.28E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.36|P-value:1.04E-6 ID:SGTC_3074|Compound:9116018|FD-Score:3.79|P-value:1.87E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.13|P-value:3.32E-4 ID:SGTC_3280|Compound:9140961|FD-Score:2.90|P-value:8.03E-4 ID:SGTC_3310|Compound:9130229|FD-Score:2.88|P-value:8.66E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.98|P-value:7.41E-6 ID:SGTC_3338|Compound:9144300|FD-Score:3.16|P-value:2.91E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.57|P-value:5.04E-5 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.88|P-value:1.14E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:5.13|P-value:1.12E-8 ID:SGTC_337|Compound:1315-0038|FD-Score:3.62|P-value:3.99E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.19|P-value:2.52E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.12|P-value:3.38E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.37|P-value:1.23E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.01|P-value:5.21E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.53|P-value:5.95E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.04|P-value:4.66E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.07|P-value:4.66E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.61|P-value:2.52E-7 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:2.87|P-value:9.08E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.23|P-value:2.23E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.33|P-value:1.43E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.90|P-value:7.92E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.45|P-value:8.75E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.09|P-value:3.78E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.81|P-value:1.65E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.66|P-value:3.34E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-4.51|P-value:4.34E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.87|P-value:1.28E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.36|P-value:1.04E-6 ID:SGTC_3074|Compound:9116018|FD-Score:3.79|P-value:1.87E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.13|P-value:3.32E-4 ID:SGTC_3280|Compound:9140961|FD-Score:2.90|P-value:8.03E-4 ID:SGTC_3310|Compound:9130229|FD-Score:2.88|P-value:8.66E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.98|P-value:7.41E-6 ID:SGTC_3338|Compound:9144300|FD-Score:3.16|P-value:2.91E-4

Top fitness defect scores for YLR351C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_291 4130-1278 5.13 35.5 µM 1.12E-8 Golgi 6 1.41E-7
2 SGTC_1240 0356-0016 4.61 42.1 µM 2.52E-7 mitochondrial response to ROS 23 1.97E-6
3 SGTC_2926 9010726 4.36 65.2 µM 1.04E-6 23 6.58E-6
4 SGTC_1214 0358-0031 4.07 63.7 µM 4.66E-6 13 2.34E-5
5 SGTC_3320 9137005 3.98 35.1 µM 7.41E-6 endomembrane recycling 15 3.47E-5
6 SGTC_2871 9038510 3.87 13.0 µM 1.28E-5 20 5.53E-5
7 SGTC_2758 dehydroepiandrosterone 3.81 69.3 µM 1.65E-5 41 6.85E-5
8 SGTC_3074 9116018 3.79 49.5 µM 1.87E-5 RNA processing & uracil transport 22 7.62E-5
9 SGTC_2799 7812892 3.66 81.8 µM 3.34E-5 superoxide 36 1.25E-4
10 SGTC_337 1315-0038 3.62 354.0 µM 3.99E-5 amide catabolism 33 1.45E-4
11 SGTC_2611 pyromycin 3.45 23.9 µM 8.75E-5 58 2.83E-4
12 SGTC_545 4218-0007 3.37 221.0 µM 1.23E-4 47 3.80E-4
13 SGTC_2126 5251174 3.25 33.9 µM 2.01E-4 67 5.77E-4
14 SGTC_2006 4011487 3.23 200.0 µM 2.23E-4 endomembrane recycling 121 6.28E-4
15 SGTC_1956 st077085 3.18 54.0 µM 2.73E-4 50 7.48E-4
16 SGTC_3338 9144300 3.16 39.6 µM 2.91E-4 Golgi 50 7.88E-4
17 SGTC_3109 9122853 3.13 49.5 µM 3.32E-4 29 8.82E-4
18 SGTC_2755 lomerizine 3.09 42.7 µM 3.78E-4 65 9.87E-4
19 SGTC_808 0711-0032 3.04 135.0 µM 4.66E-4 49 0.00118
20 SGTC_705 1124-0212 3.01 310.0 µM 5.21E-4 53 0.00130

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.25E-13 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.123 9.04E-13 YIL013C PDR11 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth
0.119 5.01E-12 YNL290W RFC3 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.100 5.99E-9 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.100 6.21E-9 YNL083W SAL1 hom ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains
0.099 9.28E-9 YPL256C CLN2 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.099 9.46E-9 YFL034C-A RPL22B hom Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication
0.097 1.60E-8 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.093 6.59E-8 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.091 1.26E-7 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.090 1.93E-7 YBL094C_d YBL094C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
0.089 2.09E-7 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.089 2.10E-7 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.085 7.46E-7 YOR101W RAS1 hom GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress
0.085 8.84E-7 YGL262W_p YGL262W_p hom Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene