YLR352W_p

Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR352W / YLR352W

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-2.89|P-value:8.91E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.03|P-value:6.79E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.46|P-value:1.23E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.94|P-value:7.68E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.87|P-value:2.11E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:5.59|P-value:1.43E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:3.98|P-value:1.24E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.23|P-value:3.58E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:2.95|P-value:9.12E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.24|P-value:3.06E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.33|P-value:1.63E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.02|P-value:5.65E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.13|P-value:4.72E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.52|P-value:7.49E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.37|P-value:1.85E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-4.30|P-value:1.92E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:3.02|P-value:7.04E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.62|P-value:4.92E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.48|P-value:9.02E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.91|P-value:1.26E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.51|P-value:7.71E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.33|P-value:1.65E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.20|P-value:2.77E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.93|P-value:9.81E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.15|P-value:4.28E-4 ID:SGTC_2107|Compound:5363541|FD-Score:2.96|P-value:8.82E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-2.89|P-value:9.05E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-2.86|P-value:9.95E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.47|P-value:1.22E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.55|P-value:8.60E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.65|P-value:5.62E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-5.04|P-value:2.99E-8 ID:SGTC_2327|Compound:6189656|FD-Score:-3.33|P-value:1.68E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.98|P-value:8.30E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-2.99|P-value:6.33E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.17|P-value:3.99E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.88|P-value:2.00E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.33|P-value:2.15E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.01|P-value:7.33E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.06|P-value:6.18E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.96|P-value:8.68E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.64|P-value:4.47E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.34|P-value:2.08E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.12|P-value:6.38E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-3.16|P-value:3.32E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.18|P-value:3.81E-4 ID:SGTC_3178|Compound:9107506|FD-Score:2.95|P-value:8.98E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-5.56|P-value:1.18E-9 ID:SGTC_11|Compound:0438-0307|FD-Score:-2.89|P-value:8.91E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.03|P-value:6.79E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.46|P-value:1.23E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-2.94|P-value:7.68E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.87|P-value:2.11E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:5.59|P-value:1.43E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:3.98|P-value:1.24E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.23|P-value:3.58E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:2.95|P-value:9.12E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.24|P-value:3.06E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.33|P-value:1.63E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.02|P-value:5.65E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.13|P-value:4.72E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.52|P-value:7.49E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.37|P-value:1.85E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-4.30|P-value:1.92E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:3.02|P-value:7.04E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.62|P-value:4.92E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.48|P-value:9.02E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.91|P-value:1.26E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.51|P-value:7.71E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.33|P-value:1.65E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.20|P-value:2.77E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.93|P-value:9.81E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.15|P-value:4.28E-4 ID:SGTC_2107|Compound:5363541|FD-Score:2.96|P-value:8.82E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-2.89|P-value:9.05E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-2.86|P-value:9.95E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.47|P-value:1.22E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.55|P-value:8.60E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.65|P-value:5.62E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-5.04|P-value:2.99E-8 ID:SGTC_2327|Compound:6189656|FD-Score:-3.33|P-value:1.68E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.98|P-value:8.30E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-2.99|P-value:6.33E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.17|P-value:3.99E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.88|P-value:2.00E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.33|P-value:2.15E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.01|P-value:7.33E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.06|P-value:6.18E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.96|P-value:8.68E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.64|P-value:4.47E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.34|P-value:2.08E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.24|P-value:3.00E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.12|P-value:6.38E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-3.16|P-value:3.32E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.18|P-value:3.81E-4 ID:SGTC_3178|Compound:9107506|FD-Score:2.95|P-value:8.98E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-5.56|P-value:1.18E-9

Top fitness defect scores for YLR352W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_149 3970-0822 5.59 46.1 µM 1.43E-9 tubulin folding & SWR complex 41 1.11E-8
2 SGTC_248 streptozotocin 4.23 5.2 mM 3.58E-6 DNA damage response 20 1.14E-5
3 SGTC_2957 9076800 4.12 11.5 µM 6.38E-6 20 1.91E-5
4 SGTC_159 3970-0959 3.98 50.0 µM 1.24E-5 74 3.46E-5
5 SGTC_2425 5628681 3.88 7.8 µM 2.00E-5 26 5.28E-5
6 SGTC_87 0100-0052 3.87 35.5 µM 2.11E-5 113 5.53E-5
7 SGTC_2316 5844804 3.65 197.4 µM 5.62E-5 44 1.32E-4
8 SGTC_2271 7849410 3.55 118.6 µM 8.60E-5 18 1.93E-4
9 SGTC_2270 7924575 3.47 90.9 µM 1.22E-4 RPP1 & pyrimidine depletion 27 2.64E-4
10 SGTC_46 0329-0187a 3.46 2.2 µM 1.23E-4 96 2.65E-4
11 SGTC_824 1304-0008 3.37 100.0 µM 1.85E-4 DNA damage response 58 3.82E-4
12 SGTC_2877 9040724 3.34 71.4 µM 2.08E-4 33 4.24E-4
13 SGTC_2427 5545055 3.33 42.8 µM 2.15E-4 37 4.36E-4
14 SGTC_2909 7941780 3.24 10.5 µM 3.00E-4 49 5.88E-4
15 SGTC_350 k064-0020 3.24 19.8 µM 3.06E-4 heme requiring 51 5.98E-4
16 SGTC_3165 9101544 3.18 49.5 µM 3.81E-4 29 7.28E-4
17 SGTC_2367 9070478 3.17 135.4 µM 3.99E-4 cell wall 71 7.59E-4
18 SGTC_2018 5133068 3.15 143.0 µM 4.28E-4 62 8.08E-4
19 SGTC_656 4090-1979 3.13 187.0 µM 4.72E-4 52 8.81E-4
20 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.06 100.0 µM 6.18E-4 61 0.00112

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.81E-18 YML035C AMD1 hom AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools
0.142 1.44E-16 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.135 4.06E-15 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.131 2.99E-14 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.121 1.83E-12 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.119 4.77E-12 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.117 1.33E-11 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.116 1.77E-11 YDR512C EMI1 hom Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs
0.108 4.05E-10 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.105 9.24E-10 YDR022C ATG31 hom Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
0.105 9.43E-10 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.102 3.37E-9 YDR067C_p OCA6_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
0.101 4.13E-9 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.097 1.57E-8 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.097 1.96E-8 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication