HIPHOP chemogenomics database

YLR355C / ILV5

Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids

Zygosity: Heterozygous strain

fixedexpanded
Profile for YLR355C / ILV5

Click on Significant Values for Screen Details

Top fitness defect scores for YLR355C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2233	sulbentine	8.70	40.4 µM	1.70E-13		12	1.66E-18	0.24
2	SGTC_966	1300-0360	8.68	30.2 µM	1.95E-13	heme requiring	4	2.01E-18	2.11
3	SGTC_70	0141-0289	8.43	43.3 µM	8.78E-13	mitochondrial stress	4	1.71E-17	0.78
4	SGTC_2759	disulfiram	8.31	3.4 µM	1.84E-12		3	4.89E-17	0.65
5	SGTC_1797	st048695	7.24	56.8 µM	7.01E-10	NEO1	3	2.26E-13	0.01
6	SGTC_2760	etidronate	6.75	98.0 µM	8.38E-9		1	7.59E-12	2.05
7	SGTC_158	k038-0087	6.07	26.4 µM	1.94E-7	ubiquinone biosynthesis & proteasome	14	6.49E-10	0.47
8	SGTC_730	1436-0052	5.69	41.2 µM	9.62E-7	mitochondrial processes	6	6.24E-9	0.09
9	SGTC_153	4077-0274	5.44	519.7 µM	2.71E-6		3	2.70E-8	0.83
10	SGTC_3077	9117319	5.28	49.5 µM	5.06E-6		3	6.50E-8	0.56
11	SGTC_459	nigericin	5.12	15.3 µM	9.38E-6		4	1.55E-7	0.28
12	SGTC_275	trichlorophene	5.11	5.7 µM	9.74E-6	mitochondrial stress	2	1.64E-7	0.66
13	SGTC_120	rhodamine 6G	5.07	52.3 µM	1.14E-5	mitochondrial processes	9	2.04E-7	0.37
14	SGTC_2696	st077691	5.01	74.3 µM	1.37E-5		8	2.66E-7	0.53
15	SGTC_2799	7812892	4.95	81.8 µM	1.72E-5	superoxide	10	3.65E-7	0.24
16	SGTC_1793	st048256	4.93	72.2 µM	1.84E-5		2	4.01E-7	0.23
17	SGTC_1533	dihydroergotamine mesylate	4.93	29.4 µM	1.84E-5	DNA intercalators	3	4.02E-7	0.40
18	SGTC_1371	2421-0008	4.75	32.7 µM	3.56E-5	mitochondrial processes	16	1.02E-6	0.02
19	SGTC_1831	st055328	4.66	12.0 µM	4.94E-5	heme biosynthesis & mitochondrial translocase	9	1.61E-6	0.22
20	SGTC_1785	bathophenanthroline	4.55	24.0 µM	7.08E-5	heme requiring	17	2.67E-6	0.15

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.280	2.76E-61	YKL195W	MIA40	het	Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.252	1.20E-49	YBR192W	RIM2	het	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.190	1.32E-28	YPL266W	DIM1	het	Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.184	6.93E-27	YBL105C	PKC1	het	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.173	7.51E-24	YMR203W	TOM40	het	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.164	1.20E-21	YJL031C	BET4	het	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.151	1.48E-18	YDR016C	DAD1	het	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.145	3.90E-17	YEL034W	HYP2	het	Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.144	5.84E-17	YCR024C	SLM5	hom	Mitochondrial asparaginyl-tRNA synthetase
0.137	1.46E-15	YLR033W	RSC58	het	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.135	3.37E-15	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.134	5.69E-15	YFR037C	RSC8	het	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.131	2.85E-14	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.130	3.50E-14	YDL205C	HEM3	het	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.127	1.45E-13	YGL068W	MNP1	het	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth