YLR367W / RPS22B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR367W / RPS22B

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:-3.58|P-value:1.33E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.53|P-value:1.44E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.15|P-value:5.98E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.91|P-value:3.00E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.10|P-value:7.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.77|P-value:6.01E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.21|P-value:8.71E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.07|P-value:8.05E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.67|P-value:8.10E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.49|P-value:2.08E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.54|P-value:1.37E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.01|P-value:9.78E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.98|P-value:2.22E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-3.13|P-value:7.18E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.21|P-value:4.84E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.41|P-value:2.32E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.60|P-value:1.08E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.39|P-value:2.50E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.14|P-value:6.92E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.01|P-value:9.94E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.34|P-value:3.35E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.13|P-value:1.26E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.30|P-value:3.52E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-15.20|P-value:9.84E-55 ID:SGTC_2584|Compound:androsterone|FD-Score:-7.54|P-value:7.03E-15 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.34|P-value:2.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.76|P-value:1.79E-9 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.51|P-value:1.75E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.06|P-value:9.25E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.30|P-value:3.53E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.31|P-value:3.39E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.13|P-value:6.59E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.91|P-value:3.42E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.19|P-value:5.84E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.19|P-value:5.87E-4 ID:SGTC_3324|Compound:9138759|FD-Score:4.44|P-value:2.64E-6 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.58|P-value:1.33E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.53|P-value:1.44E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.15|P-value:5.98E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.91|P-value:3.00E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.29|P-value:3.62E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.10|P-value:7.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.77|P-value:6.01E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.21|P-value:8.71E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.07|P-value:8.05E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.67|P-value:8.10E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:4.49|P-value:2.08E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.54|P-value:1.37E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.01|P-value:9.78E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.98|P-value:2.22E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-3.13|P-value:7.18E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.21|P-value:4.84E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.41|P-value:2.32E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.60|P-value:1.08E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.39|P-value:2.50E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.14|P-value:6.92E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.01|P-value:9.94E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-3.34|P-value:3.35E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.13|P-value:1.26E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.30|P-value:3.52E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-15.20|P-value:9.84E-55 ID:SGTC_2584|Compound:androsterone|FD-Score:-7.54|P-value:7.03E-15 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.34|P-value:2.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.76|P-value:1.79E-9 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.51|P-value:1.75E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.06|P-value:9.25E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.30|P-value:3.53E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.31|P-value:3.39E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.13|P-value:6.59E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.91|P-value:3.42E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.19|P-value:5.84E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.19|P-value:5.87E-4 ID:SGTC_3324|Compound:9138759|FD-Score:4.44|P-value:2.64E-6

Top fitness defect scores for YLR367W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 5.76 96.7 µM 1.79E-9 calcium & mitochondrial duress 172 4.31E-9
2 SGTC_1302 1159-0335 4.49 255.0 µM 2.08E-6 6 3.64E-6
3 SGTC_3324 9138759 4.44 60.8 µM 2.64E-6 11 4.58E-6
4 SGTC_1880 MG-132 3.98 525.0 µM 2.22E-5 17 3.48E-5
5 SGTC_405 ebelactone b 3.91 50.0 µM 3.00E-5 18 4.65E-5
6 SGTC_1249 0481-0015 3.67 10.2 µM 8.10E-5 32 1.20E-4
7 SGTC_2287 7945887 3.60 168.8 µM 1.08E-4 12 1.57E-4
8 SGTC_3268 9137683 3.58 49.5 µM 1.19E-4 13 1.74E-4
9 SGTC_1375 2910-0797 3.54 186.0 µM 1.37E-4 39 1.99E-4
10 SGTC_130 0136-0219 3.53 337.7 µM 1.44E-4 35 2.07E-4
11 SGTC_2281 7943571 3.41 200.0 µM 2.32E-4 22 3.28E-4
12 SGTC_2398 5228213 3.39 48.8 µM 2.50E-4 iron homeostasis 69 3.52E-4
13 SGTC_2587 piperic acid 3.34 92.2 µM 2.98E-4 40 4.16E-4
14 SGTC_3055 9094636 3.31 49.5 µM 3.39E-4 27 4.70E-4
15 SGTC_2580 diallyl disulphide 3.30 81.4 µM 3.52E-4 40 4.88E-4
16 SGTC_2996 9066192 3.30 71.4 µM 3.53E-4 67 4.89E-4
17 SGTC_746 1095-0025 3.29 46.6 µM 3.62E-4 RSC & ERG11 33 5.01E-4
18 SGTC_2054 5233173 3.21 129.0 µM 4.84E-4 mitochondrial response to ROS 96 6.61E-4
19 SGTC_305 1682-2595 3.15 20.8 µM 5.98E-4 RNA processing & uracil transport 47 8.09E-4
20 SGTC_3175 9106517 3.13 49.5 µM 6.59E-4 iron homeostasis 43 8.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 6.45E-51 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.245 5.42E-47 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.224 3.04E-39 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.223 4.90E-39 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.217 3.60E-37 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.202 2.73E-32 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.202 3.73E-32 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.196 1.89E-30 YDL052C SLC1 hom 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.192 3.36E-29 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.187 8.71E-28 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.181 5.42E-26 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.181 5.71E-26 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.174 3.17E-24 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.165 5.99E-22 YIL121W QDR2 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.162 3.96E-21 YER017C AFG3 hom Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging