YLR378C / SEC61

Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR378C / SEC61

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.24|P-value:2.44E-8 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.29|P-value:2.82E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.82|P-value:2.68E-7 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.52|P-value:1.14E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.45|P-value:1.81E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:9.37|P-value:7.73E-23 ID:SGTC_86|Compound:0417-1630|FD-Score:7.09|P-value:7.38E-14 ID:SGTC_137|Compound:0438-0332|FD-Score:3.68|P-value:6.42E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.97|P-value:1.91E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:11.30|P-value:1.72E-32 ID:SGTC_165|Compound:k038-0023|FD-Score:4.23|P-value:5.33E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:3.91|P-value:2.43E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.65|P-value:7.28E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.25|P-value:3.66E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:7.04|P-value:1.06E-13 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.97|P-value:1.60E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:6.28|P-value:2.93E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:11.40|P-value:7.52E-33 ID:SGTC_398|Compound:bronopol|FD-Score:-3.51|P-value:1.15E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.11|P-value:6.06E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-2.96|P-value:9.55E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.79|P-value:3.10E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:3.67|P-value:6.89E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.05|P-value:1.27E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:5.56|P-value:3.47E-9 ID:SGTC_642|Compound:0335-0876|FD-Score:4.07|P-value:1.15E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:5.48|P-value:5.68E-9 ID:SGTC_774|Compound:k060-0086|FD-Score:3.11|P-value:6.06E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.22|P-value:5.65E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:3.31|P-value:2.95E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:4.99|P-value:1.04E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:6.48|P-value:7.39E-12 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.75|P-value:4.26E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.94|P-value:2.11E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.89|P-value:2.54E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:5.24|P-value:2.45E-8 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.08|P-value:6.12E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.62|P-value:8.50E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.59|P-value:9.49E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.16|P-value:5.06E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.07|P-value:7.00E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.46|P-value:1.42E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.09|P-value:6.72E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.20|P-value:3.98E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.17|P-value:4.47E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.88|P-value:1.57E-7 ID:SGTC_1843|Compound:st055809|FD-Score:-3.39|P-value:1.89E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.09|P-value:6.59E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.51|P-value:1.32E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.39|P-value:2.10E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.06|P-value:7.30E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.10|P-value:5.59E-8 ID:SGTC_2043|Compound:5101342|FD-Score:3.10|P-value:6.38E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-5.36|P-value:9.98E-9 ID:SGTC_2195|Compound:6536160|FD-Score:-3.25|P-value:3.25E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.79|P-value:3.62E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.43|P-value:2.00E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.97|P-value:1.79E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.38|P-value:2.57E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-5.06|P-value:5.94E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.14|P-value:5.51E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.36|P-value:2.41E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.04|P-value:7.83E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.05|P-value:7.61E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.75|P-value:4.26E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.12|P-value:5.88E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.97|P-value:1.78E-5 ID:SGTC_3135|Compound:9127742|FD-Score:3.05|P-value:7.64E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-4.58|P-value:8.13E-7 ID:SGTC_3334|Compound:9142812|FD-Score:3.36|P-value:2.37E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.24|P-value:2.44E-8 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.29|P-value:2.82E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.82|P-value:2.68E-7 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.52|P-value:1.14E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.45|P-value:1.81E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:9.37|P-value:7.73E-23 ID:SGTC_86|Compound:0417-1630|FD-Score:7.09|P-value:7.38E-14 ID:SGTC_137|Compound:0438-0332|FD-Score:3.68|P-value:6.42E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:6.97|P-value:1.91E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:11.30|P-value:1.72E-32 ID:SGTC_165|Compound:k038-0023|FD-Score:4.23|P-value:5.33E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:3.91|P-value:2.43E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.65|P-value:7.28E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.25|P-value:3.66E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:7.04|P-value:1.06E-13 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.97|P-value:1.60E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:6.28|P-value:2.93E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:11.40|P-value:7.52E-33 ID:SGTC_398|Compound:bronopol|FD-Score:-3.51|P-value:1.15E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.11|P-value:6.06E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-2.96|P-value:9.55E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.79|P-value:3.10E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:3.67|P-value:6.89E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:4.05|P-value:1.27E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:5.56|P-value:3.47E-9 ID:SGTC_642|Compound:0335-0876|FD-Score:4.07|P-value:1.15E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:5.48|P-value:5.68E-9 ID:SGTC_774|Compound:k060-0086|FD-Score:3.11|P-value:6.06E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.22|P-value:5.65E-6 ID:SGTC_826|Compound:1683-5028|FD-Score:3.31|P-value:2.95E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:4.99|P-value:1.04E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:6.48|P-value:7.39E-12 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.75|P-value:4.26E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.94|P-value:2.11E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.89|P-value:2.54E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:5.24|P-value:2.45E-8 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.08|P-value:6.12E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.62|P-value:8.50E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.59|P-value:9.49E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.16|P-value:5.06E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.30|P-value:3.04E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.07|P-value:7.00E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.46|P-value:1.42E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.09|P-value:6.72E-4 ID:SGTC_1743|Compound:st037606|FD-Score:-3.20|P-value:3.98E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.17|P-value:4.47E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.88|P-value:1.57E-7 ID:SGTC_1843|Compound:st055809|FD-Score:-3.39|P-value:1.89E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.09|P-value:6.59E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.51|P-value:1.32E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.39|P-value:2.10E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.06|P-value:7.30E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.10|P-value:5.59E-8 ID:SGTC_2043|Compound:5101342|FD-Score:3.10|P-value:6.38E-4 ID:SGTC_2191|Compound:5911152|FD-Score:-5.36|P-value:9.98E-9 ID:SGTC_2195|Compound:6536160|FD-Score:-3.25|P-value:3.25E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.30|P-value:3.03E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.79|P-value:3.62E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.43|P-value:2.00E-6 ID:SGTC_2413|Compound:inermin|FD-Score:3.97|P-value:1.79E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.38|P-value:2.57E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-5.06|P-value:5.94E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.14|P-value:5.51E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.36|P-value:2.41E-4 ID:SGTC_2822|Compound:7994718|FD-Score:3.04|P-value:7.83E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.05|P-value:7.61E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.75|P-value:4.26E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.12|P-value:5.88E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.97|P-value:1.78E-5 ID:SGTC_3135|Compound:9127742|FD-Score:3.05|P-value:7.64E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-4.58|P-value:8.13E-7 ID:SGTC_3334|Compound:9142812|FD-Score:3.36|P-value:2.37E-4

Top fitness defect scores for YLR378C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_367 0335-0881 11.40 7.1 µM 7.52E-33 ubiquinone biosynthesis & proteasome 3 2.30E-30 2.35
2 SGTC_158 k038-0087 11.30 26.4 µM 1.72E-32 ubiquinone biosynthesis & proteasome 4 4.91E-30 1.32
3 SGTC_67 0335-0847 9.37 266.0 µM 7.73E-23 ubiquinone biosynthesis & proteasome 3 3.66E-21 2.60
4 SGTC_86 0417-1630 7.09 471.9 µM 7.38E-14 ubiquinone biosynthesis & proteasome 7 6.65E-13 0.30
5 SGTC_294 k038-0071 7.04 157.0 µM 1.06E-13 ubiquinone biosynthesis & proteasome 6 9.28E-13 1.33
6 SGTC_142 0335-0849 6.97 62.7 µM 1.91E-13 ubiquinone biosynthesis & proteasome 8 1.60E-12 0.16
7 SGTC_846 0335-0850 6.48 148.0 µM 7.39E-12 ubiquinone biosynthesis & proteasome 3 4.62E-11 1.79
8 SGTC_340 k038-0059 6.28 454.0 µM 2.93E-11 ubiquinone biosynthesis & proteasome 5 1.64E-10 1.79
9 SGTC_635 k038-0028 5.56 24.7 µM 3.47E-9 ubiquinone biosynthesis & proteasome 6 1.33E-8 0.66
10 SGTC_768 0384-0033 5.48 77.3 µM 5.68E-9 fatty acid desaturase (OLE1) 11 2.10E-8 0.69
11 SGTC_16 erodoxin 5.24 22.8 µM 2.44E-8 unfolded protein response 16 8.05E-8 0.05
12 SGTC_978 1416-0512 5.24 87.4 µM 2.45E-8 redox potentiating 2 8.09E-8 0.69
13 SGTC_2021 4019055 5.10 173.0 µM 5.59E-8 endomembrane recycling 26 1.73E-7 0.28
14 SGTC_837 0091-0265 4.99 12.5 µM 1.04E-7 ubiquinone biosynthesis & proteasome 6 3.07E-7 0.64
15 SGTC_36 0335-0881 4.82 14.2 µM 2.68E-7 ubiquinone biosynthesis & proteasome 25 7.35E-7 0.26
16 SGTC_568 1193-0097 4.79 7.5 µM 3.10E-7 ERAD & cell cycle 20 8.41E-7 0.11
17 SGTC_64 000l-0018 4.45 272.1 µM 1.81E-6 ubiquinone biosynthesis & proteasome 41 4.28E-6 0.01
18 SGTC_2249 haloperidol 4.43 116.4 µM 2.00E-6 ergosterol depletion effects on membrane 29 4.69E-6 0.01
19 SGTC_2485 5633444 4.38 17.8 µM 2.57E-6 redox potentiating 8 5.91E-6 0.29
20 SGTC_165 k038-0023 4.23 64.4 µM 5.33E-6 ubiquinone biosynthesis & proteasome 21 1.16E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.562 1.98E-279 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.536 1.18E-248 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.490 2.74E-202 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.484 2.49E-196 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.477 5.68E-190 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.468 2.65E-182 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.465 1.99E-179 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.447 3.46E-164 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.443 2.25E-161 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.441 1.42E-159 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.439 6.84E-158 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.428 2.43E-149 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.419 3.75E-143 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.414 3.82E-139 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.408 7.29E-135 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding