YLR380W / CSR1

Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR380W / CSR1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.12|P-value:5.36E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.34|P-value:2.30E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.42|P-value:2.03E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:3.24|P-value:3.47E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.24|P-value:3.45E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.40|P-value:2.22E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:3.90|P-value:2.26E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.99|P-value:1.55E-5 ID:SGTC_444|Compound:curcumin|FD-Score:6.26|P-value:3.72E-11 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.17|P-value:6.75E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:3.08|P-value:6.14E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.70|P-value:8.37E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.47|P-value:4.42E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:6.68|P-value:1.92E-12 ID:SGTC_644|Compound:1498-1197|FD-Score:4.41|P-value:2.10E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:4.49|P-value:1.40E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:4.79|P-value:2.90E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:10.60|P-value:2.33E-28 ID:SGTC_758|Compound:0868-0029|FD-Score:-8.10|P-value:5.09E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:3.12|P-value:5.41E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.93|P-value:1.97E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:13.80|P-value:7.89E-47 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.42|P-value:1.69E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.78|P-value:6.09E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.07|P-value:9.07E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.08|P-value:6.12E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.41|P-value:1.77E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-3.32|P-value:3.67E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.16|P-value:4.57E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.51|P-value:1.82E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.10|P-value:5.82E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.51|P-value:1.21E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.25|P-value:4.79E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.29|P-value:4.12E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.27|P-value:1.97E-8 ID:SGTC_2363|Compound:9053361|FD-Score:3.63|P-value:7.32E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.33|P-value:2.40E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.28|P-value:2.98E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.38|P-value:2.00E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.29|P-value:2.86E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.59|P-value:8.79E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.59|P-value:1.33E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.09|P-value:5.87E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.97|P-value:2.64E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.12|P-value:5.36E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.34|P-value:2.30E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.42|P-value:2.03E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:3.24|P-value:3.47E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.24|P-value:3.45E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.40|P-value:2.22E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:3.90|P-value:2.26E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.99|P-value:1.55E-5 ID:SGTC_444|Compound:curcumin|FD-Score:6.26|P-value:3.72E-11 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.17|P-value:6.75E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:3.08|P-value:6.14E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.70|P-value:8.37E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.47|P-value:4.42E-15 ID:SGTC_637|Compound:1181-0519|FD-Score:6.68|P-value:1.92E-12 ID:SGTC_644|Compound:1498-1197|FD-Score:4.41|P-value:2.10E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:4.49|P-value:1.40E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:4.79|P-value:2.90E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:10.60|P-value:2.33E-28 ID:SGTC_758|Compound:0868-0029|FD-Score:-8.10|P-value:5.09E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:3.12|P-value:5.41E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.93|P-value:1.97E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:13.80|P-value:7.89E-47 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.42|P-value:1.69E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.78|P-value:6.09E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.07|P-value:9.07E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.08|P-value:6.12E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.41|P-value:1.77E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-3.32|P-value:3.67E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.16|P-value:4.57E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.51|P-value:1.82E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.10|P-value:5.82E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.51|P-value:1.21E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.25|P-value:4.79E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.29|P-value:4.12E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.27|P-value:1.97E-8 ID:SGTC_2363|Compound:9053361|FD-Score:3.63|P-value:7.32E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.33|P-value:2.40E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.28|P-value:2.98E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.38|P-value:2.00E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.29|P-value:2.86E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.59|P-value:8.79E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.59|P-value:1.33E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.09|P-value:5.87E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.97|P-value:2.64E-5

Top fitness defect scores for YLR380W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1161 k007-0610 13.80 110.0 µM 7.89E-47 ERAD & cell cycle 7 8.22E-44
2 SGTC_733 4069-0007 10.60 56.1 µM 2.33E-28 ERAD & cell cycle 11 1.59E-26
3 SGTC_568 1193-0097 7.47 7.5 µM 4.42E-15 ERAD & cell cycle 40 4.15E-14
4 SGTC_637 1181-0519 6.68 7.3 µM 1.92E-12 fatty acid desaturase (OLE1) 44 1.21E-11
5 SGTC_444 curcumin 6.26 90.4 µM 3.72E-11 iron homeostasis 4 1.92E-10
6 SGTC_2249 haloperidol 5.27 116.4 µM 1.97E-8 ergosterol depletion effects on membrane 57 6.69E-8
7 SGTC_658 3253-0951 4.79 102.0 µM 2.90E-7 calcium & mitochondrial duress 35 8.21E-7
8 SGTC_649 1123-0311 4.49 367.0 µM 1.40E-6 endomembrane recycling 50 3.55E-6
9 SGTC_312 4092-0653 4.42 6.8 µM 2.03E-6 ergosterol depletion effects on membrane 73 5.03E-6
10 SGTC_644 1498-1197 4.41 63.3 µM 2.10E-6 7 5.20E-6
11 SGTC_363 0455-0021 4.40 3.1 µM 2.22E-6 azole & statin 51 5.48E-6
12 SGTC_546 peri-Naphthalide 4.17 147.0 µM 6.75E-6 DNA damage response 14 1.54E-5
13 SGTC_384 k007-0144 3.99 5.2 µM 1.55E-5 ERAD & cell cycle 59 3.34E-5
14 SGTC_846 0335-0850 3.93 148.0 µM 1.97E-5 ubiquinone biosynthesis & proteasome 32 4.18E-5
15 SGTC_372 0155-0182 3.90 15.9 µM 2.26E-5 mitochondrial response to ROS 29 4.75E-5
16 SGTC_2363 9053361 3.63 176.0 µM 7.32E-5 Golgi 40 1.42E-4
17 SGTC_2780 5215298 3.59 71.4 µM 8.79E-5 52 1.68E-4
18 SGTC_2050 5263056 3.51 171.0 µM 1.21E-4 fatty acid desaturase (OLE1) 64 2.27E-4
19 SGTC_1310 1188-0297 3.42 994.0 nM 1.69E-4 azole & statin 46 3.09E-4
20 SGTC_1679 4130-1276 3.41 6.7 µM 1.77E-4 Golgi 97 3.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.462 1.07E-176 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.344 4.15E-94 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.338 1.55E-90 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.299 1.65E-70 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.292 5.21E-67 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.288 6.62E-65 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.248 2.12E-48 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.239 5.91E-45 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.239 1.18E-44 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.236 9.27E-44 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.223 3.93E-39 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.222 1.12E-38 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.221 1.88E-38 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.219 1.13E-37 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.213 1.20E-35 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress