YLR385C / SWC7

Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR385C / SWC7

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.35|P-value:3.36E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.26|P-value:4.68E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.37|P-value:3.69E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.34|P-value:3.57E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.53|P-value:2.65E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.28|P-value:5.00E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:4.32|P-value:6.01E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.76|P-value:8.19E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.29|P-value:6.81E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-3.21|P-value:6.42E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.30|P-value:4.08E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.10|P-value:1.63E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.14|P-value:8.29E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.75|P-value:8.40E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-3.28|P-value:4.98E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.15|P-value:7.99E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.27|P-value:5.17E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.34|P-value:3.58E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.03|P-value:2.19E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.19|P-value:1.11E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.82|P-value:5.40E-7 ID:SGTC_2786|Compound:7743617|FD-Score:3.22|P-value:5.42E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.11|P-value:9.25E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.33|P-value:4.18E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.35|P-value:3.36E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.26|P-value:4.68E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.37|P-value:3.69E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.34|P-value:3.57E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.53|P-value:2.65E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.28|P-value:5.00E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:4.32|P-value:6.01E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.76|P-value:8.19E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:4.29|P-value:6.81E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-3.21|P-value:6.42E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.30|P-value:4.08E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.10|P-value:1.63E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.14|P-value:8.29E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-3.75|P-value:8.40E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-3.28|P-value:4.98E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.15|P-value:7.99E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.27|P-value:5.17E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.34|P-value:3.58E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.03|P-value:2.19E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.19|P-value:1.11E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.82|P-value:5.40E-7 ID:SGTC_2786|Compound:7743617|FD-Score:3.22|P-value:5.42E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.11|P-value:9.25E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.33|P-value:4.18E-4

Top fitness defect scores for YLR385C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2779 methotrexate 4.82 400.0 µM 5.40E-7 18 7.34E-7
2 SGTC_1432 4049-0298 4.32 68.4 µM 6.01E-6 3 7.78E-6
3 SGTC_1496 4469-0713 4.29 57.4 µM 6.81E-6 15 8.79E-6
4 SGTC_2765 myclobutanil 4.19 7.7 µM 1.11E-5 azole & statin 43 1.41E-5
5 SGTC_2059 5238311 4.10 157.0 µM 1.63E-5 18 2.06E-5
6 SGTC_2762 leflunomide 4.03 42.1 µM 2.19E-5 23 2.76E-5
7 SGTC_1083 didemethylchlorpromazine sulfoxide 3.49 707.4 nM 2.03E-4 redox potentiating 105 2.45E-4
8 SGTC_6 0844-0013 3.35 19.8 µM 3.36E-4 157 4.00E-4
9 SGTC_1002 4049-0206 3.34 172.0 µM 3.57E-4 69 4.25E-4
10 SGTC_2758 dehydroepiandrosterone 3.34 69.3 µM 3.58E-4 68 4.26E-4
11 SGTC_1929 genistein trimethyl ether 3.30 50.5 µM 4.08E-4 37 4.84E-4
12 SGTC_387 norethindrone acetate 3.26 66.7 µM 4.68E-4 41 5.54E-4
13 SGTC_2786 7743617 3.22 45.5 µM 5.42E-4 56 6.40E-4
14 SGTC_1486 3970-0793 3.04 4.5 µM 0.00102 29 0.00119
15 SGTC_1105 epirubicin 2.98 18.1 µM 0.00123 anthracycline transcription coupled DNA repair 58 0.00143
16 SGTC_2787 5284540 2.98 71.4 µM 0.00126 70 0.00146
17 SGTC_2072 5231554 2.97 129.0 µM 0.00126 40 0.00147
18 SGTC_2152 5568786 2.97 200.0 µM 0.00128 45 0.00148
19 SGTC_2875 9039966 2.97 71.4 µM 0.00130 38 0.00150
20 SGTC_1842 st055362 2.97 61.2 µM 0.00130 60 0.00151

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.233 1.07E-42 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.174 2.93E-24 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.173 5.49E-24 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.169 5.55E-23 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.168 1.39E-22 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.164 1.45E-21 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.163 2.30E-21 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.161 7.35E-21 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.160 9.19E-21 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.158 4.21E-20 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.153 4.07E-19 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.152 9.09E-19 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.150 1.83E-18 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.149 5.10E-18 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.148 7.54E-18 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture