YLR390W-A / CCW14

Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR390W-A / CCW14

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-2.69|P-value:6.20E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.74|P-value:6.60E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.60|P-value:9.05E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:2.67|P-value:8.86E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.07|P-value:1.60E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.85|P-value:3.14E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.40|P-value:3.24E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:2.83|P-value:4.63E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.90|P-value:3.39E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.43|P-value:2.04E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.43|P-value:2.07E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.28|P-value:5.76E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.08|P-value:1.54E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.95|P-value:1.68E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.29|P-value:5.71E-5 ID:SGTC_1839|Compound:st053978|FD-Score:-4.01|P-value:8.56E-7 ID:SGTC_1910|Compound:st062352|FD-Score:-2.68|P-value:6.51E-4 ID:SGTC_1941|Compound:st076221|FD-Score:2.74|P-value:6.74E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-2.88|P-value:2.86E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.64|P-value:7.82E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.84|P-value:2.28E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-2.65|P-value:7.54E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.06|P-value:1.24E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-2.73|P-value:5.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-9.88|P-value:3.65E-32 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-8.37|P-value:1.20E-23 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-10.30|P-value:1.35E-34 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.85|P-value:3.17E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.48|P-value:2.20E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.18|P-value:9.32E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.11|P-value:9.97E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-4.82|P-value:4.60E-9 ID:SGTC_2962|Compound:9082311|FD-Score:-4.27|P-value:1.68E-7 ID:SGTC_2996|Compound:9066192|FD-Score:2.71|P-value:7.42E-4 ID:SGTC_3149|Compound:9097855|FD-Score:2.92|P-value:3.09E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-2.67|P-value:6.98E-4 ID:SGTC_3324|Compound:9138759|FD-Score:2.94|P-value:2.83E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.69|P-value:6.20E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.74|P-value:6.60E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-2.60|P-value:9.05E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:2.67|P-value:8.86E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.07|P-value:1.60E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-2.85|P-value:3.14E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.40|P-value:3.24E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:2.83|P-value:4.63E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.90|P-value:3.39E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.43|P-value:2.04E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.43|P-value:2.07E-5 ID:SGTC_1701|Compound:st028638|FD-Score:3.28|P-value:5.76E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.08|P-value:1.54E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.95|P-value:1.68E-6 ID:SGTC_1831|Compound:st055328|FD-Score:3.29|P-value:5.71E-5 ID:SGTC_1839|Compound:st053978|FD-Score:-4.01|P-value:8.56E-7 ID:SGTC_1910|Compound:st062352|FD-Score:-2.68|P-value:6.51E-4 ID:SGTC_1941|Compound:st076221|FD-Score:2.74|P-value:6.74E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-2.88|P-value:2.86E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.64|P-value:7.82E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.84|P-value:2.28E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-2.65|P-value:7.54E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.06|P-value:1.24E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-2.73|P-value:5.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-9.88|P-value:3.65E-32 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-8.37|P-value:1.20E-23 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-10.30|P-value:1.35E-34 ID:SGTC_2755|Compound:lomerizine|FD-Score:-2.85|P-value:3.17E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.48|P-value:2.20E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.18|P-value:9.32E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.11|P-value:9.97E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-4.82|P-value:4.60E-9 ID:SGTC_2962|Compound:9082311|FD-Score:-4.27|P-value:1.68E-7 ID:SGTC_2996|Compound:9066192|FD-Score:2.71|P-value:7.42E-4 ID:SGTC_3149|Compound:9097855|FD-Score:2.92|P-value:3.09E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-2.67|P-value:6.98E-4 ID:SGTC_3324|Compound:9138759|FD-Score:2.94|P-value:2.83E-4

Top fitness defect scores for YLR390W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1717 st033143 3.95 58.0 µM 1.68E-6 40 3.87E-5
2 SGTC_2760 etidronate 3.48 98.0 µM 2.20E-5 42 2.53E-4
3 SGTC_1360 1598-0022 3.40 39.8 µM 3.24E-5 ERG2 52 3.35E-4
4 SGTC_1831 st055328 3.29 12.0 µM 5.71E-5 heme biosynthesis & mitochondrial translocase 50 5.08E-4
5 SGTC_1701 st028638 3.28 40.4 µM 5.76E-5 36 5.11E-4
6 SGTC_2919 7978188 3.18 46.4 µM 9.32E-5 52 7.27E-4
7 SGTC_1713 st033146 3.08 12.8 µM 1.54E-4 70 0.00105
8 SGTC_1204 4049-0315 3.07 18.3 µM 1.60E-4 74 0.00108
9 SGTC_3324 9138759 2.94 60.8 µM 2.83E-4 56 0.00164
10 SGTC_3149 9097855 2.92 49.5 µM 3.09E-4 Golgi 73 0.00175
11 SGTC_1607 st000305 2.90 50.6 µM 3.39E-4 53 0.00188
12 SGTC_1529 apigenin 2.83 74.0 µM 4.63E-4 95 0.00236
13 SGTC_421 streptovitacin 2.74 30.0 mM 6.60E-4 98 0.00307
14 SGTC_1941 st076221 2.74 61.8 µM 6.74E-4 sphingolipid biosynthesis & PDR1 167 0.00311
15 SGTC_2996 9066192 2.71 71.4 µM 7.42E-4 120 0.00334
16 SGTC_863 0466-0191 2.67 129.0 µM 8.86E-4 cell wall 143 0.00381
17 SGTC_2379 9035213 2.63 200.0 µM 0.00103 101 0.00425
18 SGTC_2613 3',4'-dimethoxydalbergione 2.61 24.6 µM 0.00111 101 0.00449
19 SGTC_3345 9148410 2.60 3.6 µM 0.00116 57 0.00464
20 SGTC_351 caspofungin 2.58 25.0 nM 0.00128 cell wall 233 0.00499

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.11E-23 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.168 1.32E-22 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.146 2.19E-17 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.139 6.84E-16 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.136 2.79E-15 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.134 6.10E-15 YBR272C HSM3 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation
0.133 1.32E-14 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.128 1.13E-13 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.127 1.46E-13 YIL011W TIR3 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
0.124 6.24E-13 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.121 2.11E-12 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.118 6.22E-12 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.117 1.31E-11 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.115 2.13E-11 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
0.115 2.56E-11 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol