YLR399C / BDF1

Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR399C / BDF1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.27|P-value:7.18E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.84|P-value:1.69E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.18|P-value:2.84E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:6.60|P-value:1.68E-10 ID:SGTC_175|Compound:3793-3120|FD-Score:3.47|P-value:3.74E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.68|P-value:3.41E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.39|P-value:4.89E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.72|P-value:1.58E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.44|P-value:4.11E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.73|P-value:2.76E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:4.23|P-value:2.26E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.00|P-value:1.71E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.99|P-value:8.60E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:6.06|P-value:3.82E-9 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.84|P-value:2.99E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.18|P-value:9.62E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:-3.47|P-value:9.88E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.14|P-value:1.00E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.22|P-value:8.60E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.53|P-value:6.58E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.94|P-value:7.07E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.18|P-value:2.78E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.64|P-value:2.13E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:5.06|P-value:6.24E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.37|P-value:5.23E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.26|P-value:2.06E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.52|P-value:3.24E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.87|P-value:9.01E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.92|P-value:7.51E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.49|P-value:3.52E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.06|P-value:4.48E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.58|P-value:2.58E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:6.30|P-value:9.80E-10 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.36|P-value:5.41E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.08|P-value:4.09E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.01|P-value:5.42E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.07|P-value:4.31E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.24|P-value:7.92E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.26|P-value:7.60E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.68|P-value:5.10E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.74|P-value:4.17E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.90|P-value:8.23E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.52|P-value:6.86E-6 ID:SGTC_1864|Compound:st057645|FD-Score:3.53|P-value:3.08E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.52|P-value:3.17E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.28|P-value:1.86E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.63|P-value:3.66E-8 ID:SGTC_2257|Compound:7960413|FD-Score:3.43|P-value:4.25E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.09|P-value:1.24E-4 ID:SGTC_2401|Compound:5128683|FD-Score:7.92|P-value:2.88E-14 ID:SGTC_2403|Compound:6032726|FD-Score:7.53|P-value:4.31E-13 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.60|P-value:2.45E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.24|P-value:8.02E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.42|P-value:1.05E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.47|P-value:3.80E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.82|P-value:1.88E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:3.53|P-value:3.12E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.72|P-value:1.56E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:6.16|P-value:2.12E-9 ID:SGTC_2831|Compound:7999036|FD-Score:-4.45|P-value:3.15E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.33|P-value:1.51E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.24|P-value:2.18E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.89|P-value:2.49E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.59|P-value:2.48E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.67|P-value:1.87E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.47|P-value:3.76E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.77|P-value:1.76E-8 ID:SGTC_20|Compound:0481-0013|FD-Score:3.27|P-value:7.18E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.84|P-value:1.69E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.18|P-value:2.84E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:6.60|P-value:1.68E-10 ID:SGTC_175|Compound:3793-3120|FD-Score:3.47|P-value:3.74E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.68|P-value:3.41E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.39|P-value:4.89E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.72|P-value:1.58E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.44|P-value:4.11E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:4.73|P-value:2.76E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:4.23|P-value:2.26E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.00|P-value:1.71E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.99|P-value:8.60E-7 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:6.06|P-value:3.82E-9 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.84|P-value:2.99E-4 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:3.18|P-value:9.62E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:-3.47|P-value:9.88E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.14|P-value:1.00E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.22|P-value:8.60E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.53|P-value:6.58E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:3.94|P-value:7.07E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.18|P-value:2.78E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.64|P-value:2.13E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:5.06|P-value:6.24E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.37|P-value:5.23E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.26|P-value:2.06E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.52|P-value:3.24E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.87|P-value:9.01E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.92|P-value:7.51E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.49|P-value:3.52E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.06|P-value:4.48E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.58|P-value:2.58E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:6.30|P-value:9.80E-10 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.36|P-value:5.41E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.08|P-value:4.09E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.01|P-value:5.42E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:4.07|P-value:4.31E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.24|P-value:7.92E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.26|P-value:7.60E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-3.68|P-value:5.10E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.74|P-value:4.17E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.90|P-value:8.23E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.52|P-value:6.86E-6 ID:SGTC_1864|Compound:st057645|FD-Score:3.53|P-value:3.08E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.52|P-value:3.17E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.28|P-value:1.86E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.63|P-value:3.66E-8 ID:SGTC_2257|Compound:7960413|FD-Score:3.43|P-value:4.25E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.09|P-value:1.24E-4 ID:SGTC_2401|Compound:5128683|FD-Score:7.92|P-value:2.88E-14 ID:SGTC_2403|Compound:6032726|FD-Score:7.53|P-value:4.31E-13 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.60|P-value:2.45E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.24|P-value:8.02E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.42|P-value:1.05E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.47|P-value:3.80E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.82|P-value:1.88E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:3.53|P-value:3.12E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.72|P-value:1.56E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:6.16|P-value:2.12E-9 ID:SGTC_2831|Compound:7999036|FD-Score:-4.45|P-value:3.15E-5 ID:SGTC_2833|Compound:9001315|FD-Score:4.33|P-value:1.51E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.24|P-value:2.18E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.89|P-value:2.49E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.59|P-value:2.48E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.67|P-value:1.87E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.47|P-value:3.76E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.77|P-value:1.76E-8

Top fitness defect scores for YLR399C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2401 5128683 7.92 200.0 µM 2.88E-14 3 1.16E-15
2 SGTC_2403 6032726 7.53 181.2 µM 4.31E-13 4 2.47E-14
3 SGTC_172 1112-0046 6.60 2.6 µM 1.68E-10 NEO1 9 2.07E-11
4 SGTC_1285 0929-0069 6.30 65.5 µM 9.80E-10 2 1.51E-10
5 SGTC_2775 cyproheptadine 6.16 69.6 µM 2.12E-9 4 3.60E-10
6 SGTC_474 dl-dihydrosphingosine 6.06 5.0 µM 3.82E-9 11 6.96E-10
7 SGTC_3350 9150499 5.77 3.6 µM 1.76E-8 cell wall 17 3.87E-9
8 SGTC_2250 alverine citrate 5.63 130.0 µM 3.66E-8 66 8.80E-9
9 SGTC_954 1189-0853 5.06 2.9 µM 6.24E-7 endomembrane recycling 17 2.11E-7
10 SGTC_471 1-acyl-paf 4.99 4.0 µM 8.60E-7 DNA intercalators 14 3.02E-7
11 SGTC_52 0329-0193 4.84 875.0 nM 1.69E-6 TSC3-RPN4 16 6.41E-7
12 SGTC_2614 arthonioic acid 4.82 13.4 µM 1.88E-6 10 7.23E-7
13 SGTC_422 cantharidin 4.73 155.0 µM 2.76E-6 cell wall signaling 36 1.11E-6
14 SGTC_179 1273-0063 4.68 6.8 µM 3.41E-6 13 1.40E-6
15 SGTC_535 2293-4129 4.53 48.2 µM 6.58E-6 NEO1 48 2.92E-6
16 SGTC_1760 st045453 4.52 10.4 µM 6.86E-6 NEO1-PIK1 124 3.06E-6
17 SGTC_2461 5755302 4.42 26.1 µM 1.05E-5 21 4.89E-6
18 SGTC_2833 9001315 4.33 45.5 µM 1.51E-5 amide catabolism 42 7.34E-6
19 SGTC_1933 st074711 4.28 15.9 µM 1.86E-5 32 9.30E-6
20 SGTC_1075 aripiprazole 4.26 15.2 µM 2.06E-5 21 1.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.32E-21 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.141 1.90E-16 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.138 1.15E-15 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.130 4.53E-14 YJL191W RPS14B hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication
0.126 2.42E-13 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.114 3.42E-11 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.113 5.00E-11 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.113 5.16E-11 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.112 6.60E-11 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.111 1.12E-10 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.104 1.54E-9 YGL054C ERV14 hom COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
0.098 1.17E-8 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.097 1.66E-8 YKR001C VPS1 hom Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
0.097 1.83E-8 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.096 2.45E-8 YNL079C TPM1 hom Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication