YLR402W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR402W / YLR402W

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.57|P-value:3.61E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.70|P-value:2.32E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.44|P-value:5.55E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.44|P-value:5.60E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.37|P-value:7.13E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.32|P-value:8.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:1.35E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.96|P-value:1.34E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:4.07|P-value:5.76E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.68|P-value:2.50E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.98|P-value:8.26E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.33|P-value:8.20E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.59|P-value:3.37E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.69|P-value:2.41E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.79|P-value:1.66E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.35|P-value:7.70E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.45|P-value:5.48E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.84|P-value:1.41E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.47|P-value:5.07E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.29|P-value:9.28E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.71|P-value:4.14E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.47|P-value:5.05E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.57|P-value:3.61E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.70|P-value:2.32E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.44|P-value:5.55E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.44|P-value:5.60E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:-3.37|P-value:7.13E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.32|P-value:8.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:1.35E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.96|P-value:1.34E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:4.07|P-value:5.76E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.68|P-value:2.50E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.98|P-value:8.26E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.33|P-value:8.20E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.59|P-value:3.37E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.69|P-value:2.41E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.79|P-value:1.66E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.35|P-value:7.70E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.45|P-value:5.48E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.84|P-value:1.41E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.47|P-value:5.07E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.29|P-value:9.28E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.71|P-value:4.14E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.47|P-value:5.05E-4

Top fitness defect scores for YLR402W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 4.96 9.4 µM 1.34E-6 30 3.54E-7
2 SGTC_383 2324-0395 4.07 7.4 µM 5.76E-5 azole & statin 31 2.32E-5
3 SGTC_1504 k297-0033 3.98 30.0 µM 8.26E-5 13 3.46E-5
4 SGTC_1915 st067105 3.79 30.6 µM 1.66E-4 RNA pol III & RNase P/MRP 49 7.48E-5
5 SGTC_117 lucigenin 3.70 22.1 µM 2.32E-4 redox potentiating 97 1.08E-4
6 SGTC_1864 st057645 3.69 30.4 µM 2.41E-4 amide catabolism 9 1.13E-4
7 SGTC_832 4083-0019 3.68 164.0 µM 2.50E-4 translation 116 1.18E-4
8 SGTC_1844 rapamycin 3.59 4.0 nM 3.37E-4 189 1.64E-4
9 SGTC_3323 9138564 3.47 53.9 µM 5.05E-4 35 2.58E-4
10 SGTC_2484 5809818 3.47 12.0 µM 5.07E-4 26 2.59E-4
11 SGTC_1995 st072814 3.45 61.1 µM 5.48E-4 24 2.81E-4
12 SGTC_118 0083-0097 3.44 135.3 µM 5.55E-4 translation 199 2.86E-4
13 SGTC_291 4130-1278 3.44 35.5 µM 5.60E-4 Golgi 28 2.89E-4
14 SGTC_1513 0337-0559 3.33 19.0 µM 8.20E-4 33 4.40E-4
15 SGTC_309 k408-0051 3.32 1.5 µM 8.28E-4 95 4.45E-4
16 SGTC_2507 purpurin 3.29 79.7 µM 9.28E-4 copper-dependent oxidative stress 65 5.05E-4
17 SGTC_1118 chelidonine 3.25 707.5 nM 0.00103 43 5.68E-4
18 SGTC_1632 st005650 3.25 90.0 µM 0.00104 57 5.72E-4
19 SGTC_785 1270-0111 3.25 65.3 µM 0.00105 57 5.80E-4
20 SGTC_1819 st053448 3.25 58.6 µM 0.00106 amide catabolism 43 5.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 2.21E-24 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.158 3.70E-20 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.158 4.84E-20 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.155 1.32E-19 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.155 1.50E-19 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.154 3.29E-19 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.147 8.77E-18 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.141 2.90E-16 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.141 3.04E-16 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.140 3.63E-16 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.137 1.50E-15 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.134 6.58E-15 YLL044W_d YLL044W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
0.129 6.67E-14 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.127 1.89E-13 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.125 3.67E-13 YJL153C INO1 hom Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element