HIPHOP chemogenomics database
YLR414C / PUN1 
Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR414C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.401 | 6.90E-130 | YGL004C | RPN14 | hom | Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p |
| 0.257 | 8.87E-52 | YLR263W | RED1 | hom | Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p |
| 0.254 | 2.17E-50 | YJL058C | BIT61 | hom | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication |
| 0.247 | 1.15E-47 | YGR139W_d | YGR139W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.241 | 1.23E-45 | YKL131W_d | YKL131W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.233 | 1.92E-42 | YLR205C | HMX1 | hom | ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants |
| 0.229 | 4.18E-41 | YLR405W | DUS4 | hom | Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p |
| 0.222 | 1.20E-38 | YJR106W | ECM27 | hom | Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p |
| 0.213 | 8.48E-36 | YPR151C | SUE1 | hom | Mitochondrial protein required for degradation of unstable forms of cytochrome c |
| 0.210 | 1.26E-34 | YJR108W | ABM1 | hom | Protein of unknown function, required for normal microtubule organization |
| 0.208 | 2.89E-34 | YCL023C_d | YCL023C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 |
| 0.198 | 4.94E-31 | YKL102C_d | YKL102C_d | hom | Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site |
| 0.193 | 1.30E-29 | YKL024C | URA6 | het | Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) |
| 0.187 | 7.27E-28 | YMR041C | ARA2 | hom | NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase |
| 0.182 | 2.13E-26 | YGR008C | STF2 | hom | Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress |