HIPHOP chemogenomics database
YLR415C_p 
Putative protein of unknown function; YLR415C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR415C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.121 | 1.90E-12 | YML114C | TAF8 | het | TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation |
| 0.111 | 1.16E-10 | YPR009W | SUT2 | hom | Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p |
| 0.095 | 3.49E-8 | YNL180C | RHO5 | hom | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity |
| 0.093 | 5.82E-8 | YOR023C | AHC1 | hom | Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex |
| 0.090 | 1.86E-7 | YKL146W | AVT3 | hom | Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |
| 0.090 | 1.94E-7 | YDL072C | YET3 | hom | Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress |
| 0.085 | 8.33E-7 | YCR022C_d | YCR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene |
| 0.083 | 1.49E-6 | YOR025W | HST3 | hom | Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism |
| 0.083 | 1.56E-6 | YDR232W | HEM1 | het | 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p |
| 0.081 | 2.32E-6 | YDR511W | ACN9 | hom | Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes |
| 0.081 | 2.62E-6 | YDL030W | PRP9 | het | Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex |
| 0.080 | 3.36E-6 | YLL047W_d | YLL047W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 |
| 0.077 | 8.03E-6 | YLR433C | CNA1 | hom | Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 |
| 0.076 | 1.04E-5 | YOR047C | STD1 | hom | Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] |
| 0.074 | 1.89E-5 | YOR245C | DGA1 | hom | Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles |