YLR415C_p

Putative protein of unknown function; YLR415C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR415C / YLR415C

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.13|P-value:2.14E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:4.14|P-value:2.04E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.94|P-value:4.77E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.94|P-value:4.70E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.33|P-value:4.87E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.55|P-value:1.92E-8 ID:SGTC_171|Compound:k064-0041|FD-Score:3.19|P-value:7.77E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.40|P-value:6.38E-6 ID:SGTC_448|Compound:monastrol|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.33|P-value:4.82E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.20|P-value:7.57E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.22|P-value:7.16E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.38|P-value:4.10E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.39|P-value:6.92E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:6.45|P-value:8.34E-11 ID:SGTC_661|Compound:1304-0007|FD-Score:4.83|P-value:8.65E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.45|P-value:3.15E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.48|P-value:2.82E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.40|P-value:6.40E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:3.26|P-value:6.23E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-4.06|P-value:2.85E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.12|P-value:2.23E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.37|P-value:4.17E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.19|P-value:7.86E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.98|P-value:3.98E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.85|P-value:6.74E-5 ID:SGTC_1666|Compound:st014829|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_1719|Compound:st032227|FD-Score:6.48|P-value:6.61E-11 ID:SGTC_1850|Compound:st056238|FD-Score:3.91|P-value:5.39E-5 ID:SGTC_2025|Compound:5147754|FD-Score:3.86|P-value:6.61E-5 ID:SGTC_2026|Compound:5148700|FD-Score:4.05|P-value:2.95E-5 ID:SGTC_2335|Compound:9018011|FD-Score:-3.89|P-value:5.88E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.08|P-value:2.64E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.36|P-value:4.31E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.70|P-value:1.23E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.77|P-value:9.49E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:4.13|P-value:2.14E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:4.14|P-value:2.04E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.94|P-value:4.77E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.94|P-value:4.70E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.33|P-value:4.87E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.55|P-value:1.92E-8 ID:SGTC_171|Compound:k064-0041|FD-Score:3.19|P-value:7.77E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.40|P-value:6.38E-6 ID:SGTC_448|Compound:monastrol|FD-Score:-3.47|P-value:2.92E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.33|P-value:4.82E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.20|P-value:7.57E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.22|P-value:7.16E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.38|P-value:4.10E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.39|P-value:6.92E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:6.45|P-value:8.34E-11 ID:SGTC_661|Compound:1304-0007|FD-Score:4.83|P-value:8.65E-7 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.45|P-value:3.15E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.48|P-value:2.82E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.40|P-value:6.40E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:3.26|P-value:6.23E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-4.06|P-value:2.85E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.12|P-value:2.23E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.37|P-value:4.17E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.61|P-value:1.74E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.19|P-value:7.86E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.98|P-value:3.98E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.85|P-value:6.74E-5 ID:SGTC_1666|Compound:st014829|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_1719|Compound:st032227|FD-Score:6.48|P-value:6.61E-11 ID:SGTC_1850|Compound:st056238|FD-Score:3.91|P-value:5.39E-5 ID:SGTC_2025|Compound:5147754|FD-Score:3.86|P-value:6.61E-5 ID:SGTC_2026|Compound:5148700|FD-Score:4.05|P-value:2.95E-5 ID:SGTC_2335|Compound:9018011|FD-Score:-3.89|P-value:5.88E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.55|P-value:2.19E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-4.08|P-value:2.64E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.36|P-value:4.31E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.70|P-value:1.23E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.77|P-value:9.49E-5

Top fitness defect scores for YLR415C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1719 st032227 6.48 49.2 µM 6.61E-11 4 4.48E-11
2 SGTC_654 1124-0271 6.45 80.9 µM 8.34E-11 2 5.68E-11
3 SGTC_165 k038-0023 5.55 64.4 µM 1.92E-8 ubiquinone biosynthesis & proteasome 31 1.44E-8
4 SGTC_661 1304-0007 4.83 33.6 µM 8.65E-7 8 6.95E-7
5 SGTC_787 4152-0075 4.40 138.0 µM 6.40E-6 15 5.33E-6
6 SGTC_578 3460-0051 4.39 92.0 µM 6.92E-6 6 5.77E-6
7 SGTC_44 0929-0055 4.14 61.2 µM 2.04E-5 30 1.73E-5
8 SGTC_37 0566-0070 4.13 1.6 µM 2.14E-5 23 1.82E-5
9 SGTC_931 2812-0076 4.12 566.0 µM 2.23E-5 19 1.90E-5
10 SGTC_2026 5148700 4.05 152.0 µM 2.95E-5 14 2.53E-5
11 SGTC_114 0364-0001 3.94 490.3 µM 4.70E-5 49 4.06E-5
12 SGTC_1850 st056238 3.91 17.0 µM 5.39E-5 RPP1 & pyrimidine depletion 22 4.66E-5
13 SGTC_2025 5147754 3.86 141.0 µM 6.61E-5 11 5.74E-5
14 SGTC_1625 st003711 3.85 30.1 µM 6.74E-5 calcium & mitochondrial duress 37 5.85E-5
15 SGTC_3318 9139014 3.77 38.6 µM 9.49E-5 18 8.28E-5
16 SGTC_3191 9110352 3.70 49.5 µM 1.23E-4 14 1.08E-4
17 SGTC_1513 0337-0559 3.61 19.0 µM 1.74E-4 24 1.54E-4
18 SGTC_2338 7999974 3.55 200.0 µM 2.19E-4 34 1.94E-4
19 SGTC_1666 st014829 3.53 29.0 µM 2.36E-4 calcium & mitochondrial duress 38 2.10E-4
20 SGTC_2497 7-hydroxyflavone 3.39 100.0 µM 3.88E-4 33 3.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.90E-12 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.111 1.16E-10 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.095 3.49E-8 YNL180C RHO5 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
0.093 5.82E-8 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.090 1.86E-7 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.090 1.94E-7 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.085 8.33E-7 YCR022C_d YCR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
0.083 1.49E-6 YOR025W HST3 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.083 1.56E-6 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.081 2.32E-6 YDR511W ACN9 hom Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
0.081 2.62E-6 YDL030W PRP9 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
0.080 3.36E-6 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.077 8.03E-6 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.076 1.04E-5 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.074 1.89E-5 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles