YLR416C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR416C / YLR416C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:4.65|P-value:9.91E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.63|P-value:1.21E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:3.34|P-value:3.13E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.98|P-value:2.50E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.02|P-value:9.85E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.03|P-value:9.45E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.30|P-value:3.63E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.11|P-value:7.11E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.38|P-value:2.64E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.65|P-value:9.68E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:5.41|P-value:1.59E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:3.43|P-value:2.21E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.52|P-value:1.55E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.71|P-value:7.32E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.98|P-value:1.76E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.71|P-value:7.23E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.27|P-value:4.03E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.08|P-value:8.12E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.35|P-value:4.73E-6 ID:SGTC_1871|Compound:st057448|FD-Score:3.96|P-value:2.51E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.78|P-value:5.47E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-4.09|P-value:1.59E-5 ID:SGTC_2040|Compound:5100729|FD-Score:5.90|P-value:7.81E-10 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-6.11|P-value:2.42E-10 ID:SGTC_2058|Compound:5236698|FD-Score:-4.35|P-value:4.64E-6 ID:SGTC_2066|Compound:5222451|FD-Score:3.72|P-value:6.83E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.37|P-value:2.76E-4 ID:SGTC_2445|Compound:5742597|FD-Score:7.76|P-value:1.03E-15 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.08|P-value:7.93E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.15|P-value:6.14E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.31|P-value:3.45E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.46|P-value:1.16E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.94|P-value:2.19E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:3.11|P-value:7.20E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.22|P-value:5.25E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.83|P-value:4.48E-5 ID:SGTC_2733|Compound:amorolfine|FD-Score:-3.06|P-value:9.42E-4 ID:SGTC_2803|Compound:7707263|FD-Score:8.59|P-value:7.93E-19 ID:SGTC_2829|Compound:7992743|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.16|P-value:6.53E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.23|P-value:4.74E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.17|P-value:5.79E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.08|P-value:7.88E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.85|P-value:4.11E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.33|P-value:3.56E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.54|P-value:1.58E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.65|P-value:9.91E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.63|P-value:1.21E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:3.34|P-value:3.13E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.98|P-value:2.50E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.02|P-value:9.85E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.03|P-value:9.45E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.30|P-value:3.63E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.11|P-value:7.11E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.38|P-value:2.64E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.65|P-value:9.68E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:5.41|P-value:1.59E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:3.43|P-value:2.21E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.52|P-value:1.55E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.71|P-value:7.32E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.98|P-value:1.76E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.22|P-value:4.91E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.71|P-value:7.23E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.27|P-value:4.03E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.08|P-value:8.12E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.35|P-value:4.73E-6 ID:SGTC_1871|Compound:st057448|FD-Score:3.96|P-value:2.51E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.78|P-value:5.47E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-4.09|P-value:1.59E-5 ID:SGTC_2040|Compound:5100729|FD-Score:5.90|P-value:7.81E-10 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-6.11|P-value:2.42E-10 ID:SGTC_2058|Compound:5236698|FD-Score:-4.35|P-value:4.64E-6 ID:SGTC_2066|Compound:5222451|FD-Score:3.72|P-value:6.83E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.37|P-value:2.76E-4 ID:SGTC_2445|Compound:5742597|FD-Score:7.76|P-value:1.03E-15 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.08|P-value:7.93E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.15|P-value:6.14E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.31|P-value:3.45E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.46|P-value:1.16E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.94|P-value:2.19E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:3.11|P-value:7.20E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.22|P-value:5.25E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.83|P-value:4.48E-5 ID:SGTC_2733|Compound:amorolfine|FD-Score:-3.06|P-value:9.42E-4 ID:SGTC_2803|Compound:7707263|FD-Score:8.59|P-value:7.93E-19 ID:SGTC_2829|Compound:7992743|FD-Score:3.17|P-value:5.88E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.16|P-value:6.53E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.23|P-value:4.74E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.17|P-value:5.79E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.08|P-value:7.88E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.85|P-value:4.11E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.33|P-value:3.56E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.54|P-value:1.58E-4

Top fitness defect scores for YLR416C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2803 7707263 8.59 71.4 µM 7.93E-19 2 4.28E-18
2 SGTC_2445 5742597 7.76 35.6 µM 1.03E-15 5 4.14E-15
3 SGTC_2040 5100729 5.90 123.0 µM 7.81E-10 12 1.79E-9
4 SGTC_2583 asiatic acid 5.46 100.0 µM 1.16E-8 17 2.38E-8
5 SGTC_576 1073-0113 5.41 22.7 µM 1.59E-8 redox potentiating 29 3.23E-8
6 SGTC_1061 3448-9325 4.98 110.0 µM 1.76E-7 9 3.23E-7
7 SGTC_2588 indole-3-carbinol 4.94 100.0 µM 2.19E-7 21 3.97E-7
8 SGTC_566 0958-0068 4.65 16.5 µM 9.68E-7 RSC & ERG11 12 1.65E-6
9 SGTC_66 0109-0187 4.65 42.4 µM 9.91E-7 25 1.69E-6
10 SGTC_1871 st057448 3.96 67.3 µM 2.51E-5 26 3.75E-5
11 SGTC_3011 9081274 3.85 71.4 µM 4.11E-5 20 6.02E-5
12 SGTC_2623 humulene 3.83 100.0 µM 4.48E-5 22 6.53E-5
13 SGTC_1914 st062367 3.78 72.6 µM 5.47E-5 25 7.92E-5
14 SGTC_2066 5222451 3.72 176.0 µM 6.83E-5 heme biosynthesis & mitochondrial translocase 38 9.79E-5
15 SGTC_1136 pergolide 3.71 1.1 µM 7.23E-5 46 1.03E-4
16 SGTC_1039 k821-0043 3.71 94.0 µM 7.32E-5 Golgi 33 1.05E-4
17 SGTC_989 1501-0895 3.52 10.3 µM 1.55E-4 16 2.15E-4
18 SGTC_1367 1812-0510 3.46 76.9 µM 1.97E-4 41 2.71E-4
19 SGTC_978 1416-0512 3.43 87.4 µM 2.21E-4 redox potentiating 44 3.02E-4
20 SGTC_541 4513-1321 3.38 94.0 µM 2.64E-4 34 3.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.54E-19 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.133 1.15E-14 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.123 1.05E-12 YOL075C_p YOL075C_p hom Putative ABC transporter
0.105 1.05E-9 YJL190C RPS22A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication
0.103 2.04E-9 YPR131C NAT3 hom Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
0.101 4.90E-9 YER168C CCA1 het ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.096 2.75E-8 YGL003C CDH1 hom Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
0.088 3.37E-7 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.086 7.06E-7 YKR078W YKR078W hom Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.085 7.48E-7 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.084 1.08E-6 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.081 2.51E-6 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.079 5.13E-6 YPL003W ULA1 hom Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
0.078 5.45E-6 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.078 6.17E-6 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation