HIPHOP chemogenomics database

YLR416C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR416C / YLR416C

Click on Significant Values for Screen Details

Top fitness defect scores for YLR416C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2803	7707263	8.59	71.4 µM	7.93E-19		2	4.28E-18
2	SGTC_2445	5742597	7.76	35.6 µM	1.03E-15		5	4.14E-15
3	SGTC_2040	5100729	5.90	123.0 µM	7.81E-10		12	1.79E-9
4	SGTC_2583	asiatic acid	5.46	100.0 µM	1.16E-8		17	2.38E-8
5	SGTC_576	1073-0113	5.41	22.7 µM	1.59E-8	redox potentiating	29	3.23E-8
6	SGTC_1061	3448-9325	4.98	110.0 µM	1.76E-7		9	3.23E-7
7	SGTC_2588	indole-3-carbinol	4.94	100.0 µM	2.19E-7		21	3.97E-7
8	SGTC_566	0958-0068	4.65	16.5 µM	9.68E-7	RSC & ERG11	12	1.65E-6
9	SGTC_66	0109-0187	4.65	42.4 µM	9.91E-7		25	1.69E-6
10	SGTC_1871	st057448	3.96	67.3 µM	2.51E-5		26	3.75E-5
11	SGTC_3011	9081274	3.85	71.4 µM	4.11E-5		20	6.02E-5
12	SGTC_2623	humulene	3.83	100.0 µM	4.48E-5		22	6.53E-5
13	SGTC_1914	st062367	3.78	72.6 µM	5.47E-5		25	7.92E-5
14	SGTC_2066	5222451	3.72	176.0 µM	6.83E-5	heme biosynthesis & mitochondrial translocase	38	9.79E-5
15	SGTC_1136	pergolide	3.71	1.1 µM	7.23E-5		46	1.03E-4
16	SGTC_1039	k821-0043	3.71	94.0 µM	7.32E-5	Golgi	33	1.05E-4
17	SGTC_989	1501-0895	3.52	10.3 µM	1.55E-4		16	2.15E-4
18	SGTC_1367	1812-0510	3.46	76.9 µM	1.97E-4		41	2.71E-4
19	SGTC_978	1416-0512	3.43	87.4 µM	2.21E-4	redox potentiating	44	3.02E-4
20	SGTC_541	4513-1321	3.38	94.0 µM	2.64E-4		34	3.57E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.154	2.54E-19	YGR082W	TOM20	het	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.133	1.15E-14	YAL062W	GDH3	hom	NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.123	1.05E-12	YOL075C_p	YOL075C_p	hom	Putative ABC transporter
0.105	1.05E-9	YJL190C	RPS22A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication
0.103	2.04E-9	YPR131C	NAT3	hom	Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
0.101	4.90E-9	YER168C	CCA1	het	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.096	2.75E-8	YGL003C	CDH1	hom	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
0.088	3.37E-7	YDR246W	TRS23	het	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.086	7.06E-7	YKR078W	YKR078W	hom	Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.085	7.48E-7	YOR292C_p	YOR292C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.084	1.08E-6	YLR018C	POM34	hom	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.081	2.51E-6	YLR119W	SRN2	hom	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.079	5.13E-6	YPL003W	ULA1	hom	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
0.078	5.45E-6	YJL159W	HSP150	hom	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.078	6.17E-6	YML070W	DAK1	hom	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation