YLR422W_p

Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR422W / YLR422W

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:3.43|P-value:5.60E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.60|P-value:3.13E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.29|P-value:8.77E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.73|P-value:1.96E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.83|P-value:1.36E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.33|P-value:7.60E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.34|P-value:1.83E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:4.86|P-value:1.93E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.09|P-value:6.58E-7 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.33|P-value:7.59E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.51|P-value:4.27E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.36|P-value:1.70E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.81|P-value:2.39E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.02|P-value:6.57E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.26|P-value:2.55E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.65|P-value:2.55E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.29|P-value:8.73E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.85|P-value:1.24E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.40|P-value:6.10E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.29|P-value:8.72E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.40|P-value:6.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.29|P-value:8.74E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.75|P-value:1.84E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.63|P-value:2.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.88|P-value:1.13E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.42|P-value:5.35E-10 ID:SGTC_2431|Compound:5490079|FD-Score:3.99|P-value:7.52E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.01|P-value:5.35E-9 ID:SGTC_2507|Compound:purpurin|FD-Score:3.35|P-value:7.17E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.51|P-value:4.27E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.13|P-value:4.30E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.13|P-value:4.34E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.60|P-value:3.09E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.52|P-value:4.08E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.43|P-value:5.60E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.60|P-value:3.13E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.29|P-value:8.77E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.87|P-value:1.17E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.73|P-value:1.96E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.83|P-value:1.36E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.33|P-value:7.60E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.34|P-value:1.83E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:4.86|P-value:1.93E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.09|P-value:6.58E-7 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.33|P-value:7.59E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.51|P-value:4.27E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.36|P-value:1.70E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.81|P-value:2.39E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.02|P-value:6.57E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.26|P-value:2.55E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.65|P-value:2.55E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.29|P-value:8.73E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.85|P-value:1.24E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.40|P-value:6.10E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.29|P-value:8.72E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.40|P-value:6.19E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.29|P-value:8.74E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.75|P-value:1.84E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.63|P-value:2.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.88|P-value:1.13E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-6.42|P-value:5.35E-10 ID:SGTC_2431|Compound:5490079|FD-Score:3.99|P-value:7.52E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:6.01|P-value:5.35E-9 ID:SGTC_2507|Compound:purpurin|FD-Score:3.35|P-value:7.17E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.51|P-value:4.27E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.13|P-value:4.30E-5 ID:SGTC_3146|Compound:9095609|FD-Score:4.13|P-value:4.34E-5 ID:SGTC_3290|Compound:9121031|FD-Score:3.60|P-value:3.09E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.52|P-value:4.08E-4

Top fitness defect scores for YLR422W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2498 4'-Methoxychalcone 6.01 54.6 µM 5.35E-9 RPP1 & pyrimidine depletion 6 9.02E-10
2 SGTC_1161 k007-0610 5.09 110.0 µM 6.58E-7 ERAD & cell cycle 78 1.82E-7
3 SGTC_958 1222-0007 4.86 33.0 µM 1.93E-6 15 5.98E-7
4 SGTC_1339 1486-1321 4.81 22.7 µM 2.39E-6 ERG2 8 7.53E-7
5 SGTC_1287 0971-0001 4.36 34.6 µM 1.70E-5 sphingolipid biosynthesis & PDR1 39 6.55E-6
6 SGTC_954 1189-0853 4.34 2.9 µM 1.83E-5 endomembrane recycling 29 7.10E-6
7 SGTC_1450 4112-4260 4.26 37.6 µM 2.55E-5 calcium & mitochondrial duress 21 1.03E-5
8 SGTC_2710 st078562 4.13 53.7 µM 4.30E-5 12 1.82E-5
9 SGTC_3146 9095609 4.13 49.5 µM 4.34E-5 11 1.84E-5
10 SGTC_1375 2910-0797 4.02 186.0 µM 6.57E-5 25 2.90E-5
11 SGTC_2431 5490079 3.99 200.0 µM 7.52E-5 34 3.37E-5
12 SGTC_2322 7413319 3.88 38.2 µM 1.13E-4 ERAD & cell cycle 155 5.25E-5
13 SGTC_656 4090-1979 3.87 187.0 µM 1.17E-4 20 5.46E-5
14 SGTC_1930 st074634 3.85 34.3 µM 1.24E-4 RNA pol III & RNase P/MRP 39 5.83E-5
15 SGTC_781 4335-2806 3.83 94.4 µM 1.36E-4 23 6.46E-5
16 SGTC_2269 7935389 3.75 174.4 µM 1.84E-4 tubulin folding & SWR complex 34 8.99E-5
17 SGTC_705 1124-0212 3.73 310.0 µM 1.96E-4 21 9.64E-5
18 SGTC_1786 berberine 3.65 21.6 µM 2.55E-4 60S ribosome export 42 1.29E-4
19 SGTC_2286 7945697 3.63 125.0 µM 2.79E-4 68 1.42E-4
20 SGTC_3290 9121031 3.60 71.4 µM 3.09E-4 20 1.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.44E-13 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.117 9.08E-12 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.108 4.05E-10 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.46E-9 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.101 5.51E-9 YGL056C SDS23 hom One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication
0.098 1.41E-8 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.089 2.39E-7 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.087 4.55E-7 YCR050C_p YCR050C_p hom Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
0.085 8.33E-7 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.084 9.67E-7 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.082 1.77E-6 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.082 2.05E-6 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.079 4.05E-6 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.078 5.78E-6 YJL038C LOH1 hom Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
0.077 7.36E-6 YBR178W_d YBR178W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C