YLR439W / MRPL4

Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR439W / MRPL4

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.23|P-value:1.26E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.93|P-value:9.72E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:5.39|P-value:1.47E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:7.67|P-value:1.30E-11 ID:SGTC_118|Compound:0083-0097|FD-Score:5.07|P-value:5.54E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.77|P-value:1.78E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.72|P-value:6.52E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.06|P-value:7.35E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:8.14|P-value:7.49E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.36|P-value:7.96E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:8.67|P-value:2.36E-14 ID:SGTC_341|Compound:1486-1430|FD-Score:4.78|P-value:1.72E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.90|P-value:7.03E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.96|P-value:8.06E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.56|P-value:2.95E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.84|P-value:3.59E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.11|P-value:1.85E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.90|P-value:3.73E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.58|P-value:9.89E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.12|P-value:1.84E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.55|P-value:3.98E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.33|P-value:8.94E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.66|P-value:4.58E-7 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.23|P-value:1.27E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.89|P-value:3.86E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.79|P-value:5.25E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.55|P-value:8.74E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.77|P-value:5.52E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.99|P-value:2.76E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.99|P-value:2.80E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.00|P-value:5.54E-26 ID:SGTC_1744|Compound:st037937|FD-Score:-3.56|P-value:8.46E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.20|P-value:1.08E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-3.53|P-value:9.26E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.47|P-value:5.40E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.77|P-value:4.44E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-4.30|P-value:7.53E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-7.06|P-value:2.82E-10 ID:SGTC_2050|Compound:5263056|FD-Score:-3.58|P-value:7.91E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-4.32|P-value:7.26E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.24|P-value:2.79E-6 ID:SGTC_2144|Compound:5628481|FD-Score:4.23|P-value:1.25E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.49|P-value:9.57E-7 ID:SGTC_2254|Compound:7938975|FD-Score:3.75|P-value:5.94E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.61|P-value:9.00E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.59|P-value:9.43E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.23|P-value:2.14E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.63|P-value:8.62E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.82|P-value:3.78E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.12|P-value:1.40E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.77|P-value:4.45E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.18|P-value:2.58E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:4.23|P-value:1.26E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.93|P-value:9.72E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:5.39|P-value:1.47E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:7.67|P-value:1.30E-11 ID:SGTC_118|Compound:0083-0097|FD-Score:5.07|P-value:5.54E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:4.77|P-value:1.78E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.72|P-value:6.52E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.06|P-value:7.35E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:8.14|P-value:7.49E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.36|P-value:7.96E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:8.67|P-value:2.36E-14 ID:SGTC_341|Compound:1486-1430|FD-Score:4.78|P-value:1.72E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.90|P-value:7.03E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.96|P-value:8.06E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:-4.56|P-value:2.95E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.84|P-value:3.59E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.11|P-value:1.85E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.90|P-value:3.73E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.58|P-value:9.89E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.12|P-value:1.84E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.55|P-value:3.98E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.33|P-value:8.94E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.66|P-value:4.58E-7 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.23|P-value:1.27E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.89|P-value:3.86E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.79|P-value:5.25E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.55|P-value:8.74E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.77|P-value:5.52E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.99|P-value:2.76E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.99|P-value:2.80E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.00|P-value:5.54E-26 ID:SGTC_1744|Compound:st037937|FD-Score:-3.56|P-value:8.46E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.20|P-value:1.08E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-3.53|P-value:9.26E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.47|P-value:5.40E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.77|P-value:4.44E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-4.30|P-value:7.53E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-7.06|P-value:2.82E-10 ID:SGTC_2050|Compound:5263056|FD-Score:-3.58|P-value:7.91E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-4.32|P-value:7.26E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:5.24|P-value:2.79E-6 ID:SGTC_2144|Compound:5628481|FD-Score:4.23|P-value:1.25E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.49|P-value:9.57E-7 ID:SGTC_2254|Compound:7938975|FD-Score:3.75|P-value:5.94E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.61|P-value:9.00E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.59|P-value:9.43E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.23|P-value:2.14E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.63|P-value:8.62E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.82|P-value:3.78E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-4.12|P-value:1.40E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.77|P-value:4.45E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.18|P-value:2.58E-6

Top fitness defect scores for YLR439W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1742 st038235 12.00 28.9 µM 5.54E-26 mitochondrial stress 6 1.17E-33
2 SGTC_310 1273-0058 8.67 1.1 µM 2.36E-14 mitochondrial stress 70 2.14E-18
3 SGTC_236 1509-0011 8.14 5.3 µM 7.49E-13 245 2.00E-16
4 SGTC_70 0141-0289 7.67 43.3 µM 1.30E-11 mitochondrial stress 43 8.48E-15
5 SGTC_173 1273-0061 6.06 2.7 µM 7.35E-8 mitochondrial stress 106 6.98E-10
6 SGTC_1247 0448-0043 5.66 5.8 µM 4.58E-7 ERG2 13 7.67E-9
7 SGTC_2232 chlorophetanol 5.49 41.5 µM 9.57E-7 TRP & mitochondrial translation 56 2.01E-8
8 SGTC_63 0099-0242 5.39 26.7 µM 1.47E-6 mitochondrial stress 42 3.51E-8
9 SGTC_2091 4-phenylthiadiazole 5.24 200.0 µM 2.79E-6 4 8.15E-8
10 SGTC_118 0083-0097 5.07 135.3 µM 5.54E-6 translation 50 1.99E-7
11 SGTC_28 pentachloropyridine N-oxide 4.93 1.6 µM 9.72E-6 TSC3-RPN4 31 4.16E-7
12 SGTC_341 1486-1430 4.78 230.0 µM 1.72E-5 10 8.80E-7
13 SGTC_119 0121-0043 4.77 24.8 µM 1.78E-5 mitochondrial stress 66 9.19E-7
14 SGTC_1189 1431-2119 4.55 7.3 µM 3.98E-5 12 2.62E-6
15 SGTC_1998 st075797 4.47 76.8 µM 5.40E-5 mitochondrial response to ROS 9 3.90E-6
16 SGTC_275 trichlorophene 4.36 5.7 µM 7.96E-5 mitochondrial stress 207 6.48E-6
17 SGTC_1240 0356-0016 4.33 42.1 µM 8.94E-5 mitochondrial response to ROS 29 7.54E-6
18 SGTC_2144 5628481 4.23 200.0 µM 1.25E-4 ERG2 17 1.17E-5
19 SGTC_10 0279-0212 4.23 42.6 µM 1.26E-4 TRP & mitochondrial translation 107 1.18E-5
20 SGTC_1371 2421-0008 4.23 32.7 µM 1.27E-4 mitochondrial processes 26 1.19E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.465 1.33E-179 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.443 2.76E-161 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.431 3.69E-152 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.425 1.18E-147 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.424 8.14E-147 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.418 1.28E-141 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.417 5.19E-141 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.408 3.52E-135 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.408 4.75E-134 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.404 3.08E-132 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.404 6.55E-132 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.401 1.81E-129 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.400 2.36E-129 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.398 6.23E-128 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.398 9.06E-128 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth