HIPHOP chemogenomics database

YLR454W_p / FMP27

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR454W / FMP27

Click on Significant Values for Screen Details

Top fitness defect scores for YLR454W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2292	7671323	6.47	168.1 µM	6.92E-12	RNA processing & uracil transport	5	4.75E-11
2	SGTC_3143	9086658	6.37	49.5 µM	1.42E-11		8	9.20E-11
3	SGTC_1725	st036284	5.73	20.6 µM	1.13E-9		7	5.15E-9
4	SGTC_1218	1348-1416	5.38	30.7 µM	9.64E-9	SWF1 & branched chain AA biosynthesis	4	3.68E-8
5	SGTC_980	1473-0395	5.29	201.0 µM	1.63E-8		2	5.99E-8
6	SGTC_817	1391-0715	5.29	46.0 µM	1.65E-8		3	6.04E-8
7	SGTC_2622	2-methoxyxanthone	5.24	59.9 µM	2.20E-8		7	7.87E-8
8	SGTC_578	3460-0051	5.21	92.0 µM	2.73E-8		2	9.59E-8
9	SGTC_1168	k815-0004	4.78	80.5 µM	2.96E-7	DNA damage response	6	8.61E-7
10	SGTC_1680	diphenhydramine	4.74	100.0 µM	3.68E-7	NEO1	16	1.05E-6
11	SGTC_2581	avocatin a	4.73	64.0 µM	3.85E-7	sphingolipid biosynthesis & PDR1	38	1.10E-6
12	SGTC_574	1315-0397	4.64	40.0 µM	6.51E-7		21	1.78E-6
13	SGTC_2752	diclazuril	4.53	33.1 µM	1.14E-6		92	2.97E-6
14	SGTC_3108	9121785	4.43	49.5 µM	1.86E-6		4	4.66E-6
15	SGTC_2569	tetrandrine	4.32	100.0 µM	3.26E-6		14	7.82E-6
16	SGTC_2723	salbutamol	4.28	83.6 µM	4.01E-6		7	9.47E-6
17	SGTC_585	0kpi-0023	4.22	191.0 µM	5.24E-6		15	1.21E-5
18	SGTC_3093	9117344	4.19	49.5 µM	6.22E-6	60S ribosome export	12	1.42E-5
19	SGTC_1074	carmofur	4.14	3.8 µM	7.89E-6	exosome	17	1.77E-5
20	SGTC_2471	5466956	4.04	24.8 µM	1.22E-5	mitochondrial processes	10	2.65E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.101	5.14E-9	YBR265W	TSC10	het	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.097	1.60E-8	YLR236C_d	YLR236C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096	2.44E-8	YOR353C	SOG2	het	Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.092	8.65E-8	YIL132C	CSM2	hom	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis
0.091	1.29E-7	YGL215W	CLG1	hom	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
0.087	4.30E-7	YPR008W	HAA1	hom	Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.086	5.94E-7	YMR305C	SCW10	hom	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.086	6.39E-7	YNL332W	THI12	hom	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
0.085	8.09E-7	YHR193C	EGD2	hom	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.084	1.12E-6	YKL021C	MAK11	het	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.084	1.22E-6	YMR145C	NDE1	hom	Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.080	3.15E-6	YDR051C	DET1	hom	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.079	4.87E-6	YKR094C	RPL40B	hom	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.072	3.02E-5	YOR382W	FIT2	hom	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.071	4.08E-5	YJR019C	TES1	hom	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids