YML009C / MRPL39

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YML009C / MRPL39

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:-3.24|P-value:5.65E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.17|P-value:7.27E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.49|P-value:1.21E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.27|P-value:2.82E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.95|P-value:9.10E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.00|P-value:7.65E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.44|P-value:2.59E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.08|P-value:5.70E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.94|P-value:1.78E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.12|P-value:4.91E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.04|P-value:1.11E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.13|P-value:4.82E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:2.94|P-value:9.51E-4 ID:SGTC_1649|Compound:st011737|FD-Score:2.94|P-value:9.40E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.91|P-value:2.02E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.54|P-value:9.84E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.95|P-value:3.32E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-4.79|P-value:5.86E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.10|P-value:9.16E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.16|P-value:7.41E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.26|P-value:2.96E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.08|P-value:9.88E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.51|P-value:1.97E-4 ID:SGTC_2965|Compound:9082772|FD-Score:5.04|P-value:6.68E-8 ID:SGTC_3048|Compound:9093155|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.17|P-value:7.15E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.24|P-value:5.65E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.17|P-value:7.27E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.49|P-value:1.21E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.27|P-value:2.82E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.95|P-value:9.10E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.00|P-value:7.65E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.44|P-value:2.59E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.08|P-value:5.70E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.94|P-value:1.78E-5 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.12|P-value:4.91E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.04|P-value:1.11E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.13|P-value:4.82E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:2.94|P-value:9.51E-4 ID:SGTC_1649|Compound:st011737|FD-Score:2.94|P-value:9.40E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.91|P-value:2.02E-5 ID:SGTC_2335|Compound:9018011|FD-Score:3.54|P-value:9.84E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.95|P-value:3.32E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-4.79|P-value:5.86E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.10|P-value:9.16E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.16|P-value:7.41E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.26|P-value:2.96E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.08|P-value:9.88E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.51|P-value:1.97E-4 ID:SGTC_2965|Compound:9082772|FD-Score:5.04|P-value:6.68E-8 ID:SGTC_3048|Compound:9093155|FD-Score:3.33|P-value:2.26E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.17|P-value:7.15E-4

Top fitness defect scores for YML009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2965 9082772 5.04 38.6 µM 6.68E-8 mitochondrial response to ROS 20 2.30E-7
2 SGTC_1379 2144-0755 4.04 36.5 µM 1.11E-5 19 2.66E-5
3 SGTC_1063 disulfiram 3.94 1.8 µM 1.78E-5 25 4.14E-5
4 SGTC_2184 6075246 3.91 200.0 µM 2.02E-5 25 4.66E-5
5 SGTC_2335 9018011 3.54 154.2 µM 9.84E-5 37 2.02E-4
6 SGTC_384 k007-0144 3.49 5.2 µM 1.21E-4 ERAD & cell cycle 78 2.45E-4
7 SGTC_3048 9093155 3.33 49.5 µM 2.26E-4 14 4.38E-4
8 SGTC_622 1348-1566 3.27 26.3 µM 2.82E-4 41 5.37E-4
9 SGTC_2753 fluvastatin 3.26 17.1 µM 2.96E-4 azole & statin 63 5.61E-4
10 SGTC_1480 1070-0044 3.13 41.2 µM 4.82E-4 45 8.82E-4
11 SGTC_1176 0848-0131 3.12 83.3 µM 4.91E-4 Golgi 50 8.98E-4
12 SGTC_916 4466-0038 3.08 42.0 nM 5.70E-4 cell wall 130 0.00103
13 SGTC_839 0122-0028 3.02 230.0 µM 7.12E-4 RSC complex & mRNA processing 89 0.00127
14 SGTC_813 k007-0158 3.00 173.0 µM 7.65E-4 fatty acid desaturase (OLE1) 97 0.00135
15 SGTC_780 0109-0199 2.95 192.0 µM 9.10E-4 63 0.00159
16 SGTC_1649 st011737 2.94 51.3 µM 9.40E-4 52 0.00164
17 SGTC_1500 4488-1866 2.94 171.0 µM 9.51E-4 RPP1 & pyrimidine depletion 68 0.00165
18 SGTC_2382 9035899 2.90 200.0 µM 0.00107 60S ribosome export 52 0.00184
19 SGTC_133 0724-0033 2.89 378.9 µM 0.00110 67 0.00190
20 SGTC_1455 4262-0120 2.88 131.0 µM 0.00118 plasma membrane duress 84 0.00201

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 9.75E-16 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.119 4.48E-12 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.118 7.64E-12 YBR116C_d YBR116C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
0.098 1.09E-8 YLR006C SSK1 hom Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
0.092 1.00E-7 YOR126C IAH1 hom Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
0.090 2.02E-7 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.082 1.73E-6 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.081 2.57E-6 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.081 3.07E-6 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.079 4.71E-6 YBR130C SHE3 hom Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
0.079 4.81E-6 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.079 4.86E-6 YGL128C CWC23 het Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
0.079 4.97E-6 YPL134C ODC1 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
0.078 5.93E-6 YMR169C ALD3 hom Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
0.077 7.81E-6 YLL059C_d YLL059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data