YML021C / UNG1

Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YML021C / UNG1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.71|P-value:7.74E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:4.28|P-value:6.28E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:11.80|P-value:7.72E-34 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.82|P-value:4.13E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.02|P-value:2.02E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:4.08|P-value:1.59E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-4.95|P-value:1.76E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.46|P-value:2.63E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.81|P-value:1.19E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.35|P-value:3.22E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.66|P-value:1.00E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.70|P-value:8.21E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:4.63|P-value:1.16E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.85|P-value:4.32E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.67|P-value:9.31E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.60|P-value:4.23E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.83|P-value:9.95E-10 ID:SGTC_1112|Compound:tnp00069|FD-Score:-9.44|P-value:1.56E-22 ID:SGTC_1200|Compound:1643-0193|FD-Score:6.15|P-value:1.69E-10 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.30|P-value:5.61E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.19|P-value:5.70E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.08|P-value:8.61E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.14|P-value:6.82E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.15|P-value:6.56E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.38|P-value:2.91E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.58|P-value:1.33E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.75|P-value:6.68E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.97|P-value:2.61E-5 ID:SGTC_1957|Compound:st077035|FD-Score:3.98|P-value:2.49E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.02|P-value:9.13E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.43|P-value:2.40E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.32|P-value:3.51E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.88|P-value:3.72E-5 ID:SGTC_2505|Compound:galangin|FD-Score:-3.12|P-value:6.50E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.01|P-value:9.41E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.59|P-value:1.10E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.47|P-value:1.74E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.82|P-value:4.24E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.06|P-value:8.69E-17 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-3.05|P-value:8.15E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.20|P-value:5.63E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.71|P-value:7.62E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.44|P-value:2.23E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.68|P-value:8.82E-7 ID:SGTC_2811|Compound:7967822|FD-Score:4.21|P-value:8.58E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.32|P-value:3.55E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.86|P-value:4.13E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.63|P-value:1.06E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.27|P-value:4.37E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.22|P-value:5.11E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.11|P-value:7.74E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.73|P-value:7.10E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.25|P-value:4.60E-4 ID:SGTC_3324|Compound:9138759|FD-Score:4.54|P-value:1.82E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:3.71|P-value:7.74E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:4.28|P-value:6.28E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:11.80|P-value:7.72E-34 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.82|P-value:4.13E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.02|P-value:2.02E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:4.08|P-value:1.59E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.34|P-value:3.37E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:-4.95|P-value:1.76E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.46|P-value:2.63E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.81|P-value:1.19E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.35|P-value:3.22E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.66|P-value:1.00E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.70|P-value:8.21E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:4.63|P-value:1.16E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.85|P-value:4.32E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.67|P-value:9.31E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.60|P-value:4.23E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.83|P-value:9.95E-10 ID:SGTC_1112|Compound:tnp00069|FD-Score:-9.44|P-value:1.56E-22 ID:SGTC_1200|Compound:1643-0193|FD-Score:6.15|P-value:1.69E-10 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.08|P-value:8.57E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.30|P-value:5.61E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.19|P-value:5.70E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.08|P-value:8.61E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.14|P-value:6.82E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.15|P-value:6.56E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.38|P-value:2.91E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.58|P-value:1.33E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.75|P-value:6.68E-5 ID:SGTC_1952|Compound:st077036|FD-Score:3.97|P-value:2.61E-5 ID:SGTC_1957|Compound:st077035|FD-Score:3.98|P-value:2.49E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.02|P-value:9.13E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.48|P-value:1.96E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.43|P-value:2.40E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.32|P-value:3.51E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.88|P-value:3.72E-5 ID:SGTC_2505|Compound:galangin|FD-Score:-3.12|P-value:6.50E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.01|P-value:9.41E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.59|P-value:1.10E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.47|P-value:1.74E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.82|P-value:4.24E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.06|P-value:8.69E-17 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-3.05|P-value:8.15E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.20|P-value:5.63E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.71|P-value:7.62E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.44|P-value:2.23E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.68|P-value:8.82E-7 ID:SGTC_2811|Compound:7967822|FD-Score:4.21|P-value:8.58E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.32|P-value:3.55E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.86|P-value:4.13E-5 ID:SGTC_2928|Compound:9011484|FD-Score:3.63|P-value:1.06E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.37|P-value:2.96E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.27|P-value:4.37E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.22|P-value:5.11E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.11|P-value:7.74E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.33|P-value:3.41E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.73|P-value:7.10E-5 ID:SGTC_3322|Compound:9139058|FD-Score:3.25|P-value:4.60E-4 ID:SGTC_3324|Compound:9138759|FD-Score:4.54|P-value:1.82E-6

Top fitness defect scores for YML021C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 11.80 9.0 µM 7.72E-34 cell wall 55 2.09E-32
2 SGTC_2688 kanamycin b 8.06 96.7 µM 8.69E-17 calcium & mitochondrial duress 63 3.90E-16
3 SGTC_1200 1643-0193 6.15 18.4 µM 1.69E-10 2 3.96E-10
4 SGTC_2780 5215298 4.68 71.4 µM 8.82E-7 21 1.43E-6
5 SGTC_1106 tegaserod maleate 4.67 11.7 µM 9.31E-7 8 1.50E-6
6 SGTC_744 1594-0068 4.66 283.0 µM 1.00E-6 amide catabolism 14 1.61E-6
7 SGTC_924 2046-0044 4.63 21.3 µM 1.16E-6 7 1.85E-6
8 SGTC_3324 9138759 4.54 60.8 µM 1.82E-6 9 2.85E-6
9 SGTC_310 1273-0058 4.46 1.1 µM 2.63E-6 mitochondrial stress 213 4.05E-6
10 SGTC_1265 0819-1001 4.30 68.8 µM 5.61E-6 16 8.37E-6
11 SGTC_55 0767-0285 4.28 6.6 µM 6.28E-6 37 9.34E-6
12 SGTC_2811 7967822 4.21 32.5 µM 8.58E-6 17 1.26E-5
13 SGTC_203 k066-0004 4.08 30.9 µM 1.59E-5 RSC & ERG11 17 2.28E-5
14 SGTC_138 0850-0259 4.02 40.9 µM 2.02E-5 cell wall 196 2.87E-5
15 SGTC_1957 st077035 3.98 62.4 µM 2.49E-5 15 3.50E-5
16 SGTC_1952 st077036 3.97 64.1 µM 2.61E-5 34 3.66E-5
17 SGTC_2443 5493264 3.88 126.7 µM 3.72E-5 22 5.13E-5
18 SGTC_2909 7941780 3.86 10.5 µM 4.13E-5 23 5.67E-5
19 SGTC_998 3996-0085 3.85 177.0 µM 4.32E-5 24 5.93E-5
20 SGTC_1801 st050089 3.75 28.4 µM 6.68E-5 NEO1-PIK1 130 9.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.273 1.31E-58 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.258 5.46E-52 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.251 1.90E-49 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.239 7.41E-45 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.233 1.04E-42 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.228 1.05E-40 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.225 1.06E-39 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.225 1.23E-39 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.219 1.12E-37 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.215 2.50E-36 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.207 1.11E-33 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.206 1.51E-33 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.203 1.47E-32 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.200 1.33E-31 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.199 3.34E-31 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds