HIPHOP chemogenomics database
YML029W / USA1 
Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YML029W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.344 | 1.00E-93 | YHL045W_d | YHL045W_d | hom | Putative protein of unknown function; not an essential gene |
| 0.341 | 8.11E-92 | YPL246C | RBD2 | hom | Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p |
| 0.313 | 4.60E-77 | YDL155W | CLB3 | hom | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress |
| 0.285 | 8.58E-64 | YIL009W | FAA3 | hom | Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 0.268 | 2.69E-56 | YOR271C_p | FSF1_p | hom | Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis |
| 0.256 | 1.94E-51 | YML025C | YML6 | het | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins |
| 0.250 | 1.22E-48 | YDR242W | AMD2 | hom | Putative amidase |
| 0.249 | 9.17E-49 | YLR040C_p | YLR040C_p | hom | Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential |
| 0.245 | 3.10E-47 | YNL123W | NMA111 | hom | Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases |
| 0.244 | 1.21E-46 | YGL090W | LIF1 | hom | Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein |
| 0.233 | 1.88E-42 | YLR317W_d | YLR317W_d | het | Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C |
| 0.233 | 1.96E-42 | YGL114W_p | YGL114W_p | hom | Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters |
| 0.227 | 1.61E-40 | YDL022W | GPD1 | hom | NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity |
| 0.217 | 6.90E-37 | YCR015C_p | YCR015C_p | hom | Putative protein of unknown function; YCR015C is not an essential gene |
| 0.210 | 8.12E-35 | YPL113C_p | YPL113C_p | hom | Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene |