YML037C_p

Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YML037C / YML037C

Click on Significant Values for Screen Details ID:SGTC_113|Compound:0099-0221|FD-Score:5.27|P-value:1.62E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.73|P-value:4.99E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.58|P-value:7.87E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.06|P-value:4.01E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.71|P-value:5.34E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.80|P-value:1.41E-34 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.89|P-value:7.71E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.54|P-value:8.66E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.12|P-value:3.05E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.85|P-value:3.41E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.59|P-value:2.48E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.41|P-value:4.88E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.67|P-value:5.96E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:9.02|P-value:7.79E-16 ID:SGTC_768|Compound:0384-0033|FD-Score:6.03|P-value:5.05E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:6.01|P-value:5.52E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.75|P-value:4.65E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.84|P-value:3.44E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.57|P-value:7.99E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-5.04|P-value:4.17E-6 ID:SGTC_1672|Compound:st016598|FD-Score:4.32|P-value:6.82E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.61|P-value:2.62E-9 ID:SGTC_1750|Compound:st081859|FD-Score:7.83|P-value:2.35E-12 ID:SGTC_1754|Compound:st042065|FD-Score:10.80|P-value:9.04E-22 ID:SGTC_1760|Compound:st045453|FD-Score:4.51|P-value:3.45E-5 ID:SGTC_1800|Compound:st050079|FD-Score:9.65|P-value:7.38E-18 ID:SGTC_1801|Compound:st050089|FD-Score:10.30|P-value:3.54E-20 ID:SGTC_1803|Compound:st050068|FD-Score:9.68|P-value:6.17E-18 ID:SGTC_1818|Compound:st052136|FD-Score:9.81|P-value:2.32E-18 ID:SGTC_2006|Compound:4011487|FD-Score:8.92|P-value:1.68E-15 ID:SGTC_2036|Compound:5160441|FD-Score:11.50|P-value:1.70E-24 ID:SGTC_2166|Compound:5933061|FD-Score:4.07|P-value:1.62E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.88|P-value:3.03E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.10|P-value:1.44E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.65|P-value:2.12E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.80|P-value:6.64E-22 ID:SGTC_2257|Compound:7960413|FD-Score:4.59|P-value:2.53E-5 ID:SGTC_2317|Compound:5986382|FD-Score:4.18|P-value:1.11E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.16|P-value:2.63E-6 ID:SGTC_2321|Compound:7390090|FD-Score:6.53|P-value:3.96E-9 ID:SGTC_2352|Compound:9027995|FD-Score:3.76|P-value:4.57E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.88|P-value:3.07E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.48|P-value:3.86E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.60|P-value:7.31E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.62|P-value:7.05E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.10|P-value:3.37E-6 ID:SGTC_2896|Compound:9052656|FD-Score:4.70|P-value:1.67E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.71|P-value:5.30E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.86|P-value:1.98E-12 ID:SGTC_3107|Compound:9121808|FD-Score:4.21|P-value:1.01E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.66|P-value:6.10E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.62|P-value:2.47E-9 ID:SGTC_3185|Compound:9108267|FD-Score:3.55|P-value:8.55E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.91|P-value:2.82E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:5.27|P-value:1.62E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.73|P-value:4.99E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.58|P-value:7.87E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.06|P-value:4.01E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.71|P-value:5.34E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:13.80|P-value:1.41E-34 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.89|P-value:7.71E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.54|P-value:8.66E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.12|P-value:3.05E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.85|P-value:3.41E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.59|P-value:2.48E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.41|P-value:4.88E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.67|P-value:5.96E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:9.02|P-value:7.79E-16 ID:SGTC_768|Compound:0384-0033|FD-Score:6.03|P-value:5.05E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:6.01|P-value:5.52E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.75|P-value:4.65E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.84|P-value:3.44E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.57|P-value:7.99E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-5.04|P-value:4.17E-6 ID:SGTC_1672|Compound:st016598|FD-Score:4.32|P-value:6.82E-5 ID:SGTC_1712|Compound:st032288|FD-Score:6.61|P-value:2.62E-9 ID:SGTC_1750|Compound:st081859|FD-Score:7.83|P-value:2.35E-12 ID:SGTC_1754|Compound:st042065|FD-Score:10.80|P-value:9.04E-22 ID:SGTC_1760|Compound:st045453|FD-Score:4.51|P-value:3.45E-5 ID:SGTC_1800|Compound:st050079|FD-Score:9.65|P-value:7.38E-18 ID:SGTC_1801|Compound:st050089|FD-Score:10.30|P-value:3.54E-20 ID:SGTC_1803|Compound:st050068|FD-Score:9.68|P-value:6.17E-18 ID:SGTC_1818|Compound:st052136|FD-Score:9.81|P-value:2.32E-18 ID:SGTC_2006|Compound:4011487|FD-Score:8.92|P-value:1.68E-15 ID:SGTC_2036|Compound:5160441|FD-Score:11.50|P-value:1.70E-24 ID:SGTC_2166|Compound:5933061|FD-Score:4.07|P-value:1.62E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.88|P-value:3.03E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.10|P-value:1.44E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.65|P-value:2.12E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.80|P-value:6.64E-22 ID:SGTC_2257|Compound:7960413|FD-Score:4.59|P-value:2.53E-5 ID:SGTC_2317|Compound:5986382|FD-Score:4.18|P-value:1.11E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.16|P-value:2.63E-6 ID:SGTC_2321|Compound:7390090|FD-Score:6.53|P-value:3.96E-9 ID:SGTC_2352|Compound:9027995|FD-Score:3.76|P-value:4.57E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.88|P-value:3.07E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.48|P-value:3.86E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.60|P-value:7.31E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.62|P-value:7.05E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.10|P-value:3.37E-6 ID:SGTC_2896|Compound:9052656|FD-Score:4.70|P-value:1.67E-5 ID:SGTC_2925|Compound:9010536|FD-Score:3.71|P-value:5.30E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.86|P-value:1.98E-12 ID:SGTC_3107|Compound:9121808|FD-Score:4.21|P-value:1.01E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.66|P-value:6.10E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.62|P-value:2.47E-9 ID:SGTC_3185|Compound:9108267|FD-Score:3.55|P-value:8.55E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.91|P-value:2.82E-4

Top fitness defect scores for YML037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 13.80 10.3 µM 1.41E-34 NEO1-PIK1 28 9.99E-44
2 SGTC_2036 5160441 11.50 105.0 µM 1.70E-24 NEO1 17 7.77E-31
3 SGTC_2250 alverine citrate 10.80 130.0 µM 6.64E-22 6 1.59E-27
4 SGTC_1754 st042065 10.80 16.1 µM 9.04E-22 NEO1-PIK1 18 2.36E-27
5 SGTC_1801 st050089 10.30 28.4 µM 3.54E-20 NEO1-PIK1 12 2.56E-25
6 SGTC_1818 st052136 9.81 56.3 µM 2.32E-18 NEO1-PIK1 2 5.36E-23
7 SGTC_1803 st050068 9.68 52.4 µM 6.17E-18 NEO1-PIK1 27 1.87E-22
8 SGTC_1800 st050079 9.65 29.1 µM 7.38E-18 NEO1-PIK1 5 2.35E-22
9 SGTC_637 1181-0519 9.02 7.3 µM 7.79E-16 fatty acid desaturase (OLE1) 26 9.02E-20
10 SGTC_2006 4011487 8.92 200.0 µM 1.68E-15 endomembrane recycling 25 2.41E-19
11 SGTC_3037 9091026 7.86 49.5 µM 1.98E-12 NEO1-PIK1 17 2.00E-15
12 SGTC_1750 st081859 7.83 2.4 µM 2.35E-12 endomembrane recycling 71 2.49E-15
13 SGTC_2249 haloperidol 6.65 116.4 µM 2.12E-9 ergosterol depletion effects on membrane 36 1.46E-11
14 SGTC_3152 9099253 6.62 49.5 µM 2.47E-9 NEO1-PIK1 45 1.77E-11
15 SGTC_1712 st032288 6.61 53.4 µM 2.62E-9 calcium & mitochondrial duress 63 1.91E-11
16 SGTC_2321 7390090 6.53 138.8 µM 3.96E-9 3 3.23E-11
17 SGTC_768 0384-0033 6.03 77.3 µM 5.05E-8 fatty acid desaturase (OLE1) 39 8.26E-10
18 SGTC_788 1182-0090 6.01 188.0 µM 5.52E-8 endomembrane recycling 33 9.25E-10
19 SGTC_113 0099-0221 5.27 2.5 µM 1.62E-6 8 6.80E-8
20 SGTC_2319 6033012 5.16 152.6 µM 2.63E-6 tubulin folding & SWR complex 18 1.26E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.591 7.55E-314 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.579 7.20E-300 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.506 1.95E-217 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.486 4.53E-198 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.471 3.53E-185 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.458 1.73E-173 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.452 1.21E-168 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.451 5.07E-168 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.445 2.11E-162 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.428 1.40E-149 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.418 3.69E-142 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.414 5.22E-139 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.412 1.06E-137 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.409 2.10E-134 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.408 5.59E-135 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W