YML048W / GSF2

ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression

Zygosity: Homozygous strain
fixedexpanded
Profile for YML048W / GSF2

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.62|P-value:9.16E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.85|P-value:4.62E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.73|P-value:4.08E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.43|P-value:6.89E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.66|P-value:8.26E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.93|P-value:1.64E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:5.44|P-value:1.43E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.96|P-value:3.27E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.04|P-value:1.01E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:4.35|P-value:9.03E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:4.91|P-value:1.19E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.65|P-value:8.38E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.70|P-value:7.24E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.35|P-value:9.14E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:4.14|P-value:1.84E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.04|P-value:2.53E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.09|P-value:2.15E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.84|P-value:2.52E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.00|P-value:2.83E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.64|P-value:8.72E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.56|P-value:4.36E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.07|P-value:2.28E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.97|P-value:3.18E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.65|P-value:8.49E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.20|P-value:1.50E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:5.29|P-value:2.61E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:8.49|P-value:1.37E-13 ID:SGTC_1594|Compound:piperine|FD-Score:4.35|P-value:9.07E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-4.10|P-value:2.09E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.45|P-value:6.36E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.80|P-value:5.38E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.92|P-value:3.68E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.95|P-value:1.03E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.64|P-value:8.72E-4 ID:SGTC_1917|Compound:st066507|FD-Score:7.52|P-value:4.76E-11 ID:SGTC_1922|Compound:5578187|FD-Score:4.80|P-value:1.80E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.29|P-value:1.12E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.75|P-value:2.15E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.71|P-value:7.06E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.54|P-value:4.72E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.06|P-value:6.75E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.81|P-value:5.25E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.68|P-value:7.63E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.76|P-value:6.05E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.53|P-value:4.86E-5 ID:SGTC_2303|Compound:7774051|FD-Score:6.47|P-value:1.24E-8 ID:SGTC_2304|Compound:7443016|FD-Score:4.46|P-value:6.19E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.96|P-value:9.68E-6 ID:SGTC_2313|Compound:7726885|FD-Score:4.23|P-value:1.36E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.39|P-value:7.93E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.72|P-value:2.42E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:9.07|P-value:2.94E-15 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.93|P-value:3.56E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.82|P-value:5.10E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.67|P-value:7.95E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.97|P-value:3.48E-12 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.97|P-value:1.40E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.44|P-value:6.51E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.23|P-value:1.36E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.02|P-value:2.65E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.10|P-value:5.76E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.68|P-value:7.68E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.71|P-value:2.55E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.96|P-value:3.28E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.65|P-value:8.27E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.96|P-value:9.90E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.91|P-value:3.85E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.71|P-value:7.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.91|P-value:3.86E-4 ID:SGTC_3147|Compound:9097027|FD-Score:5.64|P-value:6.05E-7 ID:SGTC_3172|Compound:9105863|FD-Score:5.68|P-value:5.07E-7 ID:SGTC_3208|Compound:9114115|FD-Score:-3.66|P-value:8.20E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.61|P-value:9.48E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.27|P-value:2.82E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:3.62|P-value:9.16E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.85|P-value:4.62E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.73|P-value:4.08E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.43|P-value:6.89E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.66|P-value:8.26E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.93|P-value:1.64E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:5.44|P-value:1.43E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.96|P-value:3.27E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.04|P-value:1.01E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:4.35|P-value:9.03E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:4.91|P-value:1.19E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.65|P-value:8.38E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.70|P-value:7.24E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.35|P-value:9.14E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:4.14|P-value:1.84E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.04|P-value:2.53E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:4.09|P-value:2.15E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:5.84|P-value:2.52E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.00|P-value:2.83E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.64|P-value:8.72E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.56|P-value:4.36E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.07|P-value:2.28E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.97|P-value:3.18E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.65|P-value:8.49E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.20|P-value:1.50E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:5.29|P-value:2.61E-6 ID:SGTC_1481|Compound:3346-2004|FD-Score:8.49|P-value:1.37E-13 ID:SGTC_1594|Compound:piperine|FD-Score:4.35|P-value:9.07E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-4.10|P-value:2.09E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.45|P-value:6.36E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.80|P-value:5.38E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.92|P-value:3.68E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.95|P-value:1.03E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.64|P-value:8.72E-4 ID:SGTC_1917|Compound:st066507|FD-Score:7.52|P-value:4.76E-11 ID:SGTC_1922|Compound:5578187|FD-Score:4.80|P-value:1.80E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.29|P-value:1.12E-4 ID:SGTC_1969|Compound:st069479|FD-Score:4.75|P-value:2.15E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.71|P-value:7.06E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.54|P-value:4.72E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.06|P-value:6.75E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.81|P-value:5.25E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.68|P-value:7.63E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.76|P-value:6.05E-4 ID:SGTC_2295|Compound:7971645|FD-Score:4.53|P-value:4.86E-5 ID:SGTC_2303|Compound:7774051|FD-Score:6.47|P-value:1.24E-8 ID:SGTC_2304|Compound:7443016|FD-Score:4.46|P-value:6.19E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-4.96|P-value:9.68E-6 ID:SGTC_2313|Compound:7726885|FD-Score:4.23|P-value:1.36E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.39|P-value:7.93E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.72|P-value:2.42E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:9.07|P-value:2.94E-15 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.93|P-value:3.56E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.82|P-value:5.10E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.67|P-value:7.95E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.97|P-value:3.48E-12 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.97|P-value:1.40E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.44|P-value:6.51E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.23|P-value:1.36E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.02|P-value:2.65E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.10|P-value:5.76E-6 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.68|P-value:7.68E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.71|P-value:2.55E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.96|P-value:3.28E-4 ID:SGTC_2884|Compound:9058502|FD-Score:-3.65|P-value:8.27E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.96|P-value:9.90E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.91|P-value:3.85E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.71|P-value:7.01E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.91|P-value:3.86E-4 ID:SGTC_3147|Compound:9097027|FD-Score:5.64|P-value:6.05E-7 ID:SGTC_3172|Compound:9105863|FD-Score:5.68|P-value:5.07E-7 ID:SGTC_3208|Compound:9114115|FD-Score:-3.66|P-value:8.20E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.61|P-value:9.48E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.27|P-value:2.82E-6

Top fitness defect scores for YML048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 9.07 48.7 µM 2.94E-15 cell wall 21 6.10E-20
2 SGTC_1481 3346-2004 8.49 36.0 µM 1.37E-13 1 1.07E-17
3 SGTC_2619 obliquin 7.97 87.9 µM 3.48E-12 cell wall 43 8.18E-16
4 SGTC_1917 st066507 7.52 28.5 µM 4.76E-11 Golgi 7 2.73E-14
5 SGTC_2303 7774051 6.47 200.0 µM 1.24E-8 4 4.75E-11
6 SGTC_682 0kpi-0099 6.04 17.0 µM 1.01E-7 23 7.83E-10
7 SGTC_2636 apigenin dimethyl ether 5.97 100.0 µM 1.40E-7 11 1.21E-9
8 SGTC_514 4466-0038 5.93 2.6 nM 1.64E-7 cell wall 75 1.50E-9
9 SGTC_879 0831-1030 5.84 162.0 µM 2.52E-7 14 2.66E-9
10 SGTC_161 4065-0411 5.73 162.2 µM 4.08E-7 31 5.07E-9
11 SGTC_3172 9105863 5.68 49.5 µM 5.07E-7 ERG2 2 6.77E-9
12 SGTC_3147 9097027 5.64 49.5 µM 6.05E-7 6 8.58E-9
13 SGTC_568 1193-0097 5.44 7.5 µM 1.43E-6 ERAD & cell cycle 72 2.70E-8
14 SGTC_1458 k015-0034 5.29 6.3 µM 2.61E-6 7 6.05E-8
15 SGTC_3223 9129970 5.27 49.5 µM 2.82E-6 4 6.69E-8
16 SGTC_2695 st077686 5.10 52.0 µM 5.76E-6 14 1.74E-7
17 SGTC_2249 haloperidol 5.06 116.4 µM 6.75E-6 ergosterol depletion effects on membrane 61 2.15E-7
18 SGTC_2994 9053520 4.96 71.4 µM 9.90E-6 RPP1 & pyrimidine depletion 11 3.58E-7
19 SGTC_1837 st055472 4.95 66.5 µM 1.03E-5 11 3.76E-7
20 SGTC_777 1315-0167 4.91 517.0 µM 1.19E-5 Golgi 15 4.56E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.13E-31 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.194 9.86E-30 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.179 1.09E-25 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.161 6.22E-21 YDR345C HXT3 hom Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication
0.159 1.72E-20 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.152 6.37E-19 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.142 1.20E-16 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.142 1.56E-16 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.138 9.11E-16 YPR119W CLB2 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.136 3.06E-15 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.132 1.60E-14 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.130 4.08E-14 YBR135W CKS1 het Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
0.129 7.75E-14 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.120 3.61E-12 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.118 6.79E-12 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly