YML052W / SUR7

Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants

Zygosity: Homozygous strain
fixedexpanded
Profile for YML052W / SUR7

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.77|P-value:9.20E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.34|P-value:5.68E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.38|P-value:7.42E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:2.75|P-value:9.94E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.97|P-value:4.13E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.10|P-value:2.82E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.82|P-value:8.69E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.57|P-value:1.81E-7 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.21|P-value:1.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:4.96E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.13|P-value:2.09E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.96|P-value:1.60E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:3.66|P-value:2.00E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-8.02|P-value:1.81E-19 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.90|P-value:6.22E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.44|P-value:3.67E-7 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.47|P-value:3.21E-7 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.04|P-value:3.63E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.11|P-value:2.71E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.52|P-value:3.64E-10 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.15|P-value:1.57E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.69|P-value:7.23E-8 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.40|P-value:4.02E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.27|P-value:9.59E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.82|P-value:8.44E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.34|P-value:8.91E-5 ID:SGTC_2101|Compound:5377231|FD-Score:2.86|P-value:6.61E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.92|P-value:5.14E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.11|P-value:2.71E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-2.78|P-value:9.79E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:2.88|P-value:5.94E-4 ID:SGTC_2254|Compound:7938975|FD-Score:4.20|P-value:1.19E-6 ID:SGTC_2282|Compound:7944268|FD-Score:3.08|P-value:2.72E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.94|P-value:4.71E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.26|P-value:1.23E-4 ID:SGTC_2371|Compound:9071574|FD-Score:4.49|P-value:2.31E-7 ID:SGTC_2374|Compound:9071832|FD-Score:3.08|P-value:2.73E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.49|P-value:4.38E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.42|P-value:6.11E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-2.79|P-value:9.47E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.79|P-value:1.05E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.40|P-value:4.48E-67 ID:SGTC_2706|Compound:st078239|FD-Score:-4.39|P-value:4.86E-7 ID:SGTC_2716|Compound:st080858|FD-Score:2.86|P-value:6.59E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.42|P-value:6.90E-5 ID:SGTC_2802|Compound:7925815|FD-Score:2.78|P-value:8.94E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-2.91|P-value:5.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.01|P-value:4.02E-4 ID:SGTC_2916|Compound:7875993|FD-Score:2.75|P-value:0.00100 ID:SGTC_2931|Compound:9014674|FD-Score:-3.07|P-value:3.19E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.05|P-value:3.44E-4 ID:SGTC_2998|Compound:9066762|FD-Score:2.94|P-value:4.82E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.81|P-value:7.96E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:2.80|P-value:8.26E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.00|P-value:3.81E-4 ID:SGTC_3161|Compound:9100388|FD-Score:2.76|P-value:9.63E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.01|P-value:3.60E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.18|P-value:1.80E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:2.77|P-value:9.20E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.34|P-value:5.68E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.38|P-value:7.42E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:2.75|P-value:9.94E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.97|P-value:4.13E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.10|P-value:2.82E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-2.82|P-value:8.69E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.57|P-value:1.81E-7 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-3.21|P-value:1.75E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.50|P-value:4.96E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.13|P-value:2.09E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.96|P-value:1.60E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:3.66|P-value:2.00E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-8.02|P-value:1.81E-19 ID:SGTC_900|Compound:1112-0045|FD-Score:-2.90|P-value:6.22E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.44|P-value:3.67E-7 ID:SGTC_980|Compound:1473-0395|FD-Score:-4.47|P-value:3.21E-7 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.04|P-value:3.63E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.11|P-value:2.71E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.52|P-value:3.64E-10 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.15|P-value:1.57E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.69|P-value:7.23E-8 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.40|P-value:4.02E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.27|P-value:9.59E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.82|P-value:8.44E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.34|P-value:8.91E-5 ID:SGTC_2101|Compound:5377231|FD-Score:2.86|P-value:6.61E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.92|P-value:5.14E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.11|P-value:2.71E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-2.78|P-value:9.79E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:2.88|P-value:5.94E-4 ID:SGTC_2254|Compound:7938975|FD-Score:4.20|P-value:1.19E-6 ID:SGTC_2282|Compound:7944268|FD-Score:3.08|P-value:2.72E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.94|P-value:4.71E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.26|P-value:1.23E-4 ID:SGTC_2371|Compound:9071574|FD-Score:4.49|P-value:2.31E-7 ID:SGTC_2374|Compound:9071832|FD-Score:3.08|P-value:2.73E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.49|P-value:4.38E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.42|P-value:6.11E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-2.79|P-value:9.47E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.79|P-value:1.05E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.40|P-value:4.48E-67 ID:SGTC_2706|Compound:st078239|FD-Score:-4.39|P-value:4.86E-7 ID:SGTC_2716|Compound:st080858|FD-Score:2.86|P-value:6.59E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.42|P-value:6.90E-5 ID:SGTC_2802|Compound:7925815|FD-Score:2.78|P-value:8.94E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-2.91|P-value:5.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.01|P-value:4.02E-4 ID:SGTC_2916|Compound:7875993|FD-Score:2.75|P-value:0.00100 ID:SGTC_2931|Compound:9014674|FD-Score:-3.07|P-value:3.19E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.05|P-value:3.44E-4 ID:SGTC_2998|Compound:9066762|FD-Score:2.94|P-value:4.82E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.81|P-value:7.96E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:2.80|P-value:8.26E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.00|P-value:3.81E-4 ID:SGTC_3161|Compound:9100388|FD-Score:2.76|P-value:9.63E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.01|P-value:3.60E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.18|P-value:1.80E-4

Top fitness defect scores for YML052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 15.40 100.0 µM 4.48E-67 redox potentiating 14 5.53E-54
2 SGTC_1239 0337-0584 4.69 35.4 µM 7.23E-8 unfolded protein response 33 1.37E-6
3 SGTC_2371 9071574 4.49 200.0 µM 2.31E-7 7 3.49E-6
4 SGTC_1241 0364-0022 4.40 50.8 µM 4.02E-7 ERG2 22 5.45E-6
5 SGTC_39 0986-0283 4.34 58.4 µM 5.68E-7 calcium & mitochondrial duress 28 7.19E-6
6 SGTC_2254 7938975 4.20 95.2 µM 1.19E-6 43 1.31E-5
7 SGTC_1132 3456-3614 4.15 2.5 µM 1.57E-6 tubulin folding & SWR complex 37 1.63E-5
8 SGTC_164 4100-3994 3.97 89.6 µM 4.13E-6 33 3.55E-5
9 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.79 3.7 µM 1.05E-5 94 7.54E-5
10 SGTC_637 1181-0519 3.66 7.3 µM 2.00E-5 fatty acid desaturase (OLE1) 120 1.27E-4
11 SGTC_2375 9072683 3.49 200.0 µM 4.38E-5 mitochondrial processes 29 2.38E-4
12 SGTC_2379 9035213 3.42 200.0 µM 6.11E-5 40 3.12E-4
13 SGTC_41 0478-0632 3.38 82.6 µM 7.42E-5 52 3.65E-4
14 SGTC_1678 st019265 3.34 80.2 µM 8.91E-5 60S ribosome export 45 4.23E-4
15 SGTC_2348 9022543 3.26 33.4 µM 1.23E-4 mitochondrial processes 50 5.48E-4
16 SGTC_3230 9131665 3.18 49.5 µM 1.80E-4 4 7.47E-4
17 SGTC_2282 7944268 3.08 200.0 µM 2.72E-4 RPP1 & pyrimidine depletion 85 0.00104
18 SGTC_2374 9071832 3.08 200.0 µM 2.73E-4 endomembrane recycling 31 0.00104
19 SGTC_3162 9099653 3.01 49.5 µM 3.60E-4 23 0.00131
20 SGTC_3133 9127736 3.00 49.5 µM 3.81E-4 58 0.00137

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.409 2.45E-135 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.366 1.46E-106 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.355 3.81E-100 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.347 8.48E-96 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.330 4.96E-86 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.310 1.33E-75 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.305 1.98E-73 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.296 1.16E-68 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.295 2.55E-68 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.274 1.18E-58 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.271 1.21E-57 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.269 1.44E-56 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.264 9.95E-55 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.261 3.21E-53 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.246 2.50E-47 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition