YML053C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YML053C / YML053C

Click on Significant Values for Screen Details ID:SGTC_629|Compound:3448-6466|FD-Score:-3.40|P-value:3.25E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.66|P-value:1.21E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.38|P-value:5.65E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.56|P-value:2.38E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.95|P-value:3.79E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.22|P-value:6.31E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.55|P-value:1.84E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.78|P-value:7.49E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.46|P-value:2.65E-4 ID:SGTC_1831|Compound:st055328|FD-Score:4.90|P-value:4.08E-7 ID:SGTC_1842|Compound:st055362|FD-Score:4.12|P-value:1.71E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.43|P-value:2.90E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-3.36|P-value:3.73E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.13|P-value:1.71E-5 ID:SGTC_2089|Compound:5281248|FD-Score:-3.45|P-value:2.69E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.17|P-value:7.18E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.46|P-value:3.56E-6 ID:SGTC_2425|Compound:5628681|FD-Score:3.81|P-value:6.38E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.92|P-value:1.31E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.16|P-value:1.02E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.09|P-value:9.19E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.53|P-value:1.93E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.32|P-value:4.44E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.13|P-value:8.12E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.40|P-value:3.25E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.66|P-value:1.21E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.26|P-value:5.06E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.38|P-value:5.65E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.56|P-value:2.38E-6 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.95|P-value:3.79E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.22|P-value:6.31E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.55|P-value:1.84E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.78|P-value:7.49E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.46|P-value:2.65E-4 ID:SGTC_1831|Compound:st055328|FD-Score:4.90|P-value:4.08E-7 ID:SGTC_1842|Compound:st055362|FD-Score:4.12|P-value:1.71E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.43|P-value:2.90E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-3.36|P-value:3.73E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.13|P-value:1.71E-5 ID:SGTC_2089|Compound:5281248|FD-Score:-3.45|P-value:2.69E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.17|P-value:7.18E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.46|P-value:3.56E-6 ID:SGTC_2425|Compound:5628681|FD-Score:3.81|P-value:6.38E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.92|P-value:1.31E-9 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.16|P-value:1.02E-7 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.09|P-value:9.19E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.53|P-value:1.93E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.32|P-value:4.44E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.13|P-value:8.12E-4

Top fitness defect scores for YML053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.92 3.7 µM 1.31E-9 14 1.62E-9
2 SGTC_2580 diallyl disulphide 5.16 81.4 µM 1.02E-7 9 1.21E-7
3 SGTC_1831 st055328 4.90 12.0 µM 4.08E-7 heme biosynthesis & mitochondrial translocase 11 4.76E-7
4 SGTC_2098 5376439 4.46 882.5 nM 3.56E-6 6 4.06E-6
5 SGTC_1842 st055362 4.12 61.2 µM 1.71E-5 13 1.91E-5
6 SGTC_2425 5628681 3.81 7.8 µM 6.38E-5 30 7.06E-5
7 SGTC_3022 9087993 3.53 49.5 µM 1.93E-4 13 2.11E-4
8 SGTC_947 3447-0010 3.26 211.0 µM 5.06E-4 37 5.49E-4
9 SGTC_2097 5376186 3.17 200.0 µM 7.18E-4 56 7.75E-4
10 SGTC_3203 9113543 3.13 49.5 µM 8.12E-4 74 8.76E-4
11 SGTC_2765 myclobutanil 3.09 7.7 µM 9.19E-4 azole & statin 86 9.90E-4
12 SGTC_2969 9091408 2.93 28.7 µM 0.00159 84 0.00171
13 SGTC_2613 3',4'-dimethoxydalbergione 2.87 24.6 µM 0.00194 74 0.00207
14 SGTC_1587 estradiol valerate 2.86 56.1 µM 0.00198 52 0.00211
15 SGTC_1756 st041558 2.85 35.5 µM 0.00202 39 0.00216
16 SGTC_2622 2-methoxyxanthone 2.84 59.9 µM 0.00211 65 0.00225
17 SGTC_6 0844-0013 2.83 19.8 µM 0.00218 239 0.00232
18 SGTC_1235 benzylparaben 2.83 21.5 µM 0.00221 58 0.00235
19 SGTC_2294 7971431 2.82 200.0 µM 0.00228 67 0.00244
20 SGTC_2018 5133068 2.75 143.0 µM 0.00276 94 0.00294

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.268 5.38E-56 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.231 7.41E-42 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.231 9.17E-42 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.207 9.81E-34 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.197 9.78E-31 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.196 1.56E-30 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.196 2.17E-30 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.191 6.89E-29 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.190 1.70E-28 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.189 2.84E-28 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.181 4.38E-26 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.178 3.54E-25 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.176 9.33E-25 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.176 1.03E-24 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.171 1.54E-23 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress