YML054C / CYB2

Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YML054C / CYB2

Click on Significant Values for Screen Details ID:SGTC_181|Compound:1447-1644|FD-Score:5.87|P-value:5.73E-10 ID:SGTC_269|Compound:exalamide|FD-Score:-3.72|P-value:1.24E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.79|P-value:9.49E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.57|P-value:2.28E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.13|P-value:4.84E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.34|P-value:2.16E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.48|P-value:4.68E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.78|P-value:9.88E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.49|P-value:3.06E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.16|P-value:4.26E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.40|P-value:4.29E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.67|P-value:1.53E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.66|P-value:1.58E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-4.50|P-value:4.27E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.16|P-value:9.82E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.05|P-value:1.14E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-4.72|P-value:1.46E-6 ID:SGTC_1630|Compound:st005209|FD-Score:-3.56|P-value:2.34E-4 ID:SGTC_1663|Compound:st014140|FD-Score:2.99|P-value:7.79E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.31|P-value:5.82E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.53|P-value:2.67E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.18|P-value:1.86E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-5.16|P-value:1.47E-7 ID:SGTC_1935|Compound:st074532|FD-Score:-4.02|P-value:3.63E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.76|P-value:1.09E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.59|P-value:8.06E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.63|P-value:6.93E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.16|P-value:4.27E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.44|P-value:3.74E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.26|P-value:4.24E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.17|P-value:4.10E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.96|P-value:8.81E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.51|P-value:1.14E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.56|P-value:2.37E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.68|P-value:1.46E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.16|P-value:9.94E-4 ID:SGTC_2877|Compound:9040724|FD-Score:2.96|P-value:8.79E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.65|P-value:6.40E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.70|P-value:1.38E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.50|P-value:1.15E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.02|P-value:6.95E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.06|P-value:3.05E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-3.77|P-value:1.03E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.24|P-value:4.63E-6 ID:SGTC_3021|Compound:9087658|FD-Score:-3.65|P-value:1.63E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.11|P-value:5.10E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.17|P-value:9.79E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-4.04|P-value:3.35E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:5.87|P-value:5.73E-10 ID:SGTC_269|Compound:exalamide|FD-Score:-3.72|P-value:1.24E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.24|P-value:3.23E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.79|P-value:9.49E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.57|P-value:2.28E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.13|P-value:4.84E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.34|P-value:2.16E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.48|P-value:4.68E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.78|P-value:9.88E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:-3.49|P-value:3.06E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.16|P-value:4.26E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.40|P-value:4.29E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.67|P-value:1.53E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.66|P-value:1.58E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:-4.50|P-value:4.27E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.16|P-value:9.82E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.05|P-value:1.14E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-4.72|P-value:1.46E-6 ID:SGTC_1630|Compound:st005209|FD-Score:-3.56|P-value:2.34E-4 ID:SGTC_1663|Compound:st014140|FD-Score:2.99|P-value:7.79E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.31|P-value:5.82E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.53|P-value:2.67E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-4.18|P-value:1.86E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-5.16|P-value:1.47E-7 ID:SGTC_1935|Compound:st074532|FD-Score:-4.02|P-value:3.63E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.76|P-value:1.09E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.59|P-value:8.06E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.63|P-value:6.93E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.16|P-value:4.27E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.44|P-value:3.74E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.26|P-value:4.24E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.17|P-value:4.10E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.96|P-value:8.81E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.51|P-value:1.14E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.56|P-value:2.37E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.68|P-value:1.46E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.16|P-value:9.94E-4 ID:SGTC_2877|Compound:9040724|FD-Score:2.96|P-value:8.79E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.65|P-value:6.40E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.70|P-value:1.38E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.50|P-value:1.15E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.02|P-value:6.95E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.06|P-value:3.05E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-3.77|P-value:1.03E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.24|P-value:4.63E-6 ID:SGTC_3021|Compound:9087658|FD-Score:-3.65|P-value:1.63E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.11|P-value:5.10E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.17|P-value:9.79E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-4.04|P-value:3.35E-5

Top fitness defect scores for YML054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_181 1447-1644 5.87 8.1 µM 5.73E-10 endomembrane recycling 15 2.21E-9
2 SGTC_2549 cedrol 4.26 20.9 µM 4.24E-6 12 1.02E-5
3 SGTC_2981 9013952 4.24 39.0 µM 4.63E-6 34 1.11E-5
4 SGTC_1539 benzyladenosine 4.05 56.0 µM 1.14E-5 14 2.61E-5
5 SGTC_2894 9048625 3.65 32.5 µM 6.40E-5 19 1.32E-4
6 SGTC_2495 cafestol 3.63 54.5 µM 6.93E-5 Golgi 29 1.43E-4
7 SGTC_2437 5741531 3.59 144.2 µM 8.06E-5 51 1.64E-4
8 SGTC_2583 asiatic acid 3.51 100.0 µM 1.14E-4 52 2.28E-4
9 SGTC_2940 9060638 3.50 45.9 µM 1.15E-4 amide catabolism 41 2.30E-4
10 SGTC_816 0325-0417 3.49 81.3 µM 1.22E-4 21 2.44E-4
11 SGTC_909 3448-9333 3.34 149.0 µM 2.16E-4 33 4.16E-4
12 SGTC_511 blebbistatin 3.24 171.0 µM 3.23E-4 DNA intercalators 38 6.07E-4
13 SGTC_2569 tetrandrine 3.17 100.0 µM 4.10E-4 56 7.60E-4
14 SGTC_1064 honokiol 3.16 6.8 µM 4.26E-4 52 7.88E-4
15 SGTC_2503 beta-caryophyllene alcohol 3.16 24.7 µM 4.27E-4 30 7.90E-4
16 SGTC_667 1498-1044 3.13 59.0 µM 4.84E-4 RPP1 & pyrimidine depletion 59 8.87E-4
17 SGTC_3026 9090633 3.11 49.5 µM 5.10E-4 59 9.32E-4
18 SGTC_2972 9093619 3.02 59.9 µM 6.95E-4 51 0.00125
19 SGTC_1663 st014140 2.99 55.4 µM 7.79E-4 60S ribosome export 55 0.00139
20 SGTC_2877 9040724 2.96 71.4 µM 8.79E-4 57 0.00155

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 3.77E-26 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.159 2.63E-20 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.135 3.83E-15 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.134 6.63E-15 YGL145W TIP20 het Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
0.120 3.03E-12 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.118 5.93E-12 YDL208W NHP2 het Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
0.112 7.44E-11 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.101 4.07E-9 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.097 2.02E-8 YER082C UTP7 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.093 6.93E-8 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.089 2.07E-7 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.084 9.76E-7 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.084 1.11E-6 YGL217C_d YGL217C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
0.083 1.37E-6 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.082 1.72E-6 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence