YML054C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YML054C-A / YML054C-A

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.29|P-value:2.08E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.51|P-value:6.75E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.03|P-value:6.00E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.89|P-value:5.61E-8 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.02|P-value:6.35E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.15|P-value:3.68E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.00|P-value:5.45E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.59|P-value:4.76E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.23|P-value:2.17E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:2.89|P-value:8.21E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.28|P-value:1.79E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.03|P-value:4.92E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.25|P-value:2.06E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.61|P-value:5.49E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.60|P-value:3.02E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.26|P-value:1.90E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.31|P-value:1.57E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.91|P-value:1.08E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-5.11|P-value:1.95E-8 ID:SGTC_1731|Compound:st035964|FD-Score:4.17|P-value:2.90E-6 ID:SGTC_1736|Compound:st036774|FD-Score:3.02|P-value:4.96E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-2.99|P-value:6.91E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.03|P-value:5.79E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.89|P-value:8.17E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.39|P-value:1.42E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.11|P-value:3.60E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.25|P-value:2.44E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.04|P-value:5.63E-4 ID:SGTC_2309|Compound:7664088|FD-Score:5.08|P-value:1.75E-8 ID:SGTC_2421|Compound:5690543|FD-Score:3.47|P-value:8.14E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-2.98|P-value:7.22E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-2.95|P-value:7.93E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.23|P-value:2.70E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.04|P-value:4.61E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.92|P-value:1.04E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.16|P-value:2.94E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.85|P-value:1.44E-5 ID:SGTC_3342|Compound:9147791|FD-Score:4.81|P-value:8.75E-8 ID:SGTC_3352|Compound:9151559|FD-Score:-3.66|P-value:4.42E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.29|P-value:2.08E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.51|P-value:6.75E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.03|P-value:6.00E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.89|P-value:5.61E-8 ID:SGTC_249|Compound:wiskostatin|FD-Score:4.02|P-value:6.35E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.15|P-value:3.68E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.00|P-value:5.45E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.59|P-value:4.76E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.23|P-value:2.17E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:2.89|P-value:8.21E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.28|P-value:1.79E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.03|P-value:4.92E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.25|P-value:2.06E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.61|P-value:5.49E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.60|P-value:3.02E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.26|P-value:1.90E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.31|P-value:1.57E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.91|P-value:1.08E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-5.11|P-value:1.95E-8 ID:SGTC_1731|Compound:st035964|FD-Score:4.17|P-value:2.90E-6 ID:SGTC_1736|Compound:st036774|FD-Score:3.02|P-value:4.96E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-2.99|P-value:6.91E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.03|P-value:5.79E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.89|P-value:8.17E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.39|P-value:1.42E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.11|P-value:3.60E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.25|P-value:2.44E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.04|P-value:5.63E-4 ID:SGTC_2309|Compound:7664088|FD-Score:5.08|P-value:1.75E-8 ID:SGTC_2421|Compound:5690543|FD-Score:3.47|P-value:8.14E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-2.98|P-value:7.22E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-2.95|P-value:7.93E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.23|P-value:2.70E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.04|P-value:4.61E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.92|P-value:1.04E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.16|P-value:2.94E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.85|P-value:1.44E-5 ID:SGTC_3342|Compound:9147791|FD-Score:4.81|P-value:8.75E-8 ID:SGTC_3352|Compound:9151559|FD-Score:-3.66|P-value:4.42E-5

Top fitness defect scores for YML054C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2309 7664088 5.08 163.9 µM 1.75E-8 8 1.87E-7
2 SGTC_236 1509-0011 4.89 5.3 µM 5.61E-8 331 5.09E-7
3 SGTC_3342 9147791 4.81 14.5 µM 8.75E-8 3 7.45E-7
4 SGTC_1246 0422-0085 4.60 105.0 µM 3.02E-7 13 2.16E-6
5 SGTC_1731 st035964 4.17 63.0 µM 2.90E-6 23 1.50E-5
6 SGTC_249 wiskostatin 4.02 11.2 µM 6.35E-6 11 2.94E-5
7 SGTC_2781 5567276 3.92 71.4 µM 1.04E-5 48 4.51E-5
8 SGTC_1717 st033143 3.91 58.0 µM 1.08E-5 42 4.66E-5
9 SGTC_2967 9089538 3.85 49.9 µM 1.44E-5 36 5.95E-5
10 SGTC_359 0081-0058 3.59 15.9 µM 4.76E-5 60S ribosome export 59 1.66E-4
11 SGTC_41 0478-0632 3.51 82.6 µM 6.75E-5 44 2.24E-4
12 SGTC_2421 5690543 3.47 90.7 µM 8.14E-5 31 2.64E-4
13 SGTC_1635 st007035 3.31 42.4 µM 1.57E-4 263 4.63E-4
14 SGTC_766 1391-0721 3.28 126.0 µM 1.79E-4 40 5.18E-4
15 SGTC_1271 0832-2808 3.26 169.0 µM 1.90E-4 29 5.48E-4
16 SGTC_813 k007-0158 3.25 173.0 µM 2.06E-4 fatty acid desaturase (OLE1) 78 5.87E-4
17 SGTC_462 ag-879 3.23 158.0 µM 2.17E-4 61 6.13E-4
18 SGTC_2783 7738165 3.16 71.4 µM 2.94E-4 61 7.96E-4
19 SGTC_2050 5263056 3.11 171.0 µM 3.60E-4 fatty acid desaturase (OLE1) 92 9.46E-4
20 SGTC_2620 irigenin 3.04 100.0 µM 4.61E-4 79 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 4.54E-51 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.252 8.69E-50 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.250 5.41E-49 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.250 7.48E-49 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.235 3.60E-43 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.230 1.48E-41 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.229 4.24E-41 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.226 3.47E-40 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.220 3.79E-38 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.220 5.16E-38 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.219 1.13E-37 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.217 4.70E-37 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.216 8.26E-37 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.216 8.89E-37 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.216 1.25E-36 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies