YML058W / SML1

Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YML058W / SML1

Click on Significant Values for Screen Details ID:SGTC_378|Compound:3970-0959|FD-Score:3.86|P-value:3.52E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.17|P-value:6.24E-7 ID:SGTC_507|Compound:nimesulide|FD-Score:-2.77|P-value:9.84E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.06|P-value:1.70E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:2.66|P-value:9.10E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-2.77|P-value:9.87E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.00|P-value:3.86E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.07|P-value:1.65E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.71|P-value:7.43E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:2.65|P-value:9.23E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.67|P-value:2.90E-8 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.25|P-value:7.30E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.97|P-value:1.86E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.67|P-value:8.64E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.07|P-value:1.65E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-2.80|P-value:8.75E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.66|P-value:9.02E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-2.97|P-value:4.45E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.04|P-value:1.26E-6 ID:SGTC_2004|Compound:4023728|FD-Score:5.59|P-value:4.52E-11 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.33|P-value:4.96E-5 ID:SGTC_2143|Compound:5623677|FD-Score:3.02|P-value:2.03E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.89|P-value:6.17E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.12|P-value:1.30E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-2.90|P-value:5.85E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.26|P-value:1.26E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-2.82|P-value:8.10E-4 ID:SGTC_2430|Compound:5571206|FD-Score:2.66|P-value:8.89E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.13|P-value:2.31E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.12|P-value:2.40E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.33|P-value:5.02E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.97|P-value:3.85E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.85|P-value:7.54E-6 ID:SGTC_3007|Compound:9078383|FD-Score:3.53|P-value:1.88E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-2.88|P-value:6.27E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.79|P-value:5.44E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.30|P-value:5.72E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.86|P-value:3.52E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.17|P-value:6.24E-7 ID:SGTC_507|Compound:nimesulide|FD-Score:-2.77|P-value:9.84E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.06|P-value:1.70E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:2.66|P-value:9.10E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-2.77|P-value:9.87E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.00|P-value:3.86E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.07|P-value:1.65E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.71|P-value:7.43E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:2.65|P-value:9.23E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.67|P-value:2.90E-8 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.25|P-value:7.30E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.97|P-value:1.86E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.67|P-value:8.64E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.07|P-value:1.65E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-2.80|P-value:8.75E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.66|P-value:9.02E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-2.97|P-value:4.45E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.04|P-value:1.26E-6 ID:SGTC_2004|Compound:4023728|FD-Score:5.59|P-value:4.52E-11 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.33|P-value:4.96E-5 ID:SGTC_2143|Compound:5623677|FD-Score:3.02|P-value:2.03E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.89|P-value:6.17E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.12|P-value:1.30E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-2.90|P-value:5.85E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.26|P-value:1.26E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-2.82|P-value:8.10E-4 ID:SGTC_2430|Compound:5571206|FD-Score:2.66|P-value:8.89E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.13|P-value:2.31E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.12|P-value:2.40E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.33|P-value:5.02E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.97|P-value:3.85E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.85|P-value:7.54E-6 ID:SGTC_3007|Compound:9078383|FD-Score:3.53|P-value:1.88E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-2.88|P-value:6.27E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.79|P-value:5.44E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.30|P-value:5.72E-5

Top fitness defect scores for YML058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2004 4023728 5.59 41.9 µM 4.52E-11 10 1.12E-8
2 SGTC_1508 1080-0625 4.67 72.9 µM 2.90E-8 10 1.51E-6
3 SGTC_453 enantio-paf c16 4.17 10.0 µM 6.24E-7 128 1.55E-5
4 SGTC_2002 4023503 4.04 131.0 µM 1.26E-6 mitochondrial processes 26 2.65E-5
5 SGTC_1590 st077108 3.97 57.8 µM 1.86E-6 8 3.56E-5
6 SGTC_378 3970-0959 3.86 8.3 µM 3.52E-6 19 5.78E-5
7 SGTC_3007 9078383 3.53 71.4 µM 1.88E-5 31 2.07E-4
8 SGTC_2129 girgensonine 3.33 121.0 µM 4.96E-5 heme biosynthesis & mitochondrial translocase 62 4.32E-4
9 SGTC_2764 methyldopa 3.33 94.7 µM 5.02E-5 37 4.36E-4
10 SGTC_3347 9188721 3.30 44.7 µM 5.72E-5 37 4.82E-4
11 SGTC_1514 1189-1591 3.25 158.0 µM 7.30E-5 74 5.80E-4
12 SGTC_2174 5790901 3.12 200.0 µM 1.30E-4 tubulin folding & SWR complex 69 9.00E-4
13 SGTC_1763 st044482 3.07 94.5 µM 1.65E-4 copper-dependent oxidative stress 47 0.00108
14 SGTC_1232 0279-0259 3.07 161.0 µM 1.65E-4 63 0.00108
15 SGTC_523 1934-0222 3.06 13.7 µM 1.70E-4 67 0.00110
16 SGTC_2143 5623677 3.02 140.5 µM 2.03E-4 22 0.00126
17 SGTC_3315 9136395 2.79 68.5 µM 5.44E-4 60 0.00268
18 SGTC_1315 1237-0019 2.71 3.7 µM 7.43E-4 62 0.00339
19 SGTC_1601 4'-hydroxyflavanone 2.67 55.5 µM 8.64E-4 RPP1 & pyrimidine depletion 108 0.00381
20 SGTC_2430 5571206 2.66 200.0 µM 8.89E-4 133 0.00389

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 8.41E-32 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.173 4.25E-24 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.160 8.68E-21 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.143 7.20E-17 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.137 1.87E-15 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.134 6.61E-15 YPR154W PIN3 hom Protein that induces appearance of [PIN+] prion when overproduced
0.133 1.22E-14 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.130 3.98E-14 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.123 8.80E-13 YNL303W_d YNL303W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.123 8.62E-13 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.121 2.32E-12 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.118 7.98E-12 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.112 6.64E-11 YMR254C_d YMR254C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.111 1.31E-10 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.108 4.14E-10 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins